Therapy and Antifungal Susceptibility Profile of Microsporum canis
AbstractMicrosporum canis is a worldwide diffused zoophilic dermatophyte which causes clinical conditions often characterised by multifocal alopecia, scaling, and circular lesions in many animal species, including humans. A large variety of oral and topical antifungal protocols is available for treating M. canis infection. However, the efficacy of these drugs and treatment protocols is variable, with treatment failure up to 40% of patients possibly due to resistance phenomena. The lack of standardised reference methods for evaluating the antifungal susceptibility of M. canis represents a major hindrance in assessing microbiological resistance in unresponsive clinical cases. Therefore, data about conventional therapy against M. canis and the protocols employed to test the antifungal activity of the most commonly employed drugs (i.e., azoles, polyenes, allylamines, and griseofulvin) have been summarised herein. This article focuses on technical parameters used for antifungal susceptibility tests, their effects on the minimum inhibitory concentration value, as well as their clinical implications. View Full-Text
Share & Cite This Article
Aneke, C.I.; Otranto, D.; Cafarchia, C. Therapy and Antifungal Susceptibility Profile of Microsporum canis. J. Fungi 2018, 4, 107.
Aneke CI, Otranto D, Cafarchia C. Therapy and Antifungal Susceptibility Profile of Microsporum canis. Journal of Fungi. 2018; 4(3):107.Chicago/Turabian Style
Aneke, Chioma I.; Otranto, Domenico; Cafarchia, Claudia. 2018. "Therapy and Antifungal Susceptibility Profile of Microsporum canis." J. Fungi 4, no. 3: 107.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.