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J. Fungi 2018, 4(3), 107; https://doi.org/10.3390/jof4030107

Therapy and Antifungal Susceptibility Profile of Microsporum canis

1
Dipartimento di Medicina Veterinaria, Università degli Studi “Aldo Moro”, 70010 Valenzano, Bari, Italy
2
Department of Veterinary Pathology and Microbiology, University of Nigeria, Nsukka 410001, Nigeria
*
Author to whom correspondence should be addressed.
Received: 30 July 2018 / Revised: 28 August 2018 / Accepted: 31 August 2018 / Published: 5 September 2018
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Abstract

Microsporum canis is a worldwide diffused zoophilic dermatophyte which causes clinical conditions often characterised by multifocal alopecia, scaling, and circular lesions in many animal species, including humans. A large variety of oral and topical antifungal protocols is available for treating M. canis infection. However, the efficacy of these drugs and treatment protocols is variable, with treatment failure up to 40% of patients possibly due to resistance phenomena. The lack of standardised reference methods for evaluating the antifungal susceptibility of M. canis represents a major hindrance in assessing microbiological resistance in unresponsive clinical cases. Therefore, data about conventional therapy against M. canis and the protocols employed to test the antifungal activity of the most commonly employed drugs (i.e., azoles, polyenes, allylamines, and griseofulvin) have been summarised herein. This article focuses on technical parameters used for antifungal susceptibility tests, their effects on the minimum inhibitory concentration value, as well as their clinical implications. View Full-Text
Keywords: Microsporum canis; antifungal susceptibility testing; broth microdilution; E-test and Disk diffusion; antifungal resistance Microsporum canis; antifungal susceptibility testing; broth microdilution; E-test and Disk diffusion; antifungal resistance
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Aneke, C.I.; Otranto, D.; Cafarchia, C. Therapy and Antifungal Susceptibility Profile of Microsporum canis. J. Fungi 2018, 4, 107.

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