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Candida–Epithelial Interactions

Mucosal & Salivary Biology Division, Dental Institute, King’s College London, London SE1 1UL, UK
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J. Fungi 2018, 4(1), 22; https://doi.org/10.3390/jof4010022
Received: 8 December 2017 / Revised: 4 February 2018 / Accepted: 6 February 2018 / Published: 8 February 2018
(This article belongs to the Special Issue Mucosal Fungal Infections)
A plethora of intricate and dynamic molecular interactions occur between microbes and the epithelial cells that form the mucosal surfaces of the human body. Fungi, particularly species of Candida, are commensal members of our microbiota, continuously interacting with epithelial cells. Transient and localised perturbations to the mucosal environment can facilitate the overgrowth of fungi, causing infection. This minireview will examine the direct and indirect mechanisms by which Candida species and epithelial cells interact with each other, and explore the factors involved in the central processes of adhesion, invasion, and destruction of host mucosal surfaces. View Full-Text
Keywords: epithelial cell; Candida; fungus; mucosal infection; commensalism; pathogenicity; microbiota epithelial cell; Candida; fungus; mucosal infection; commensalism; pathogenicity; microbiota
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Richardson, J.P.; Ho, J.; Naglik, J.R. Candida–Epithelial Interactions. J. Fungi 2018, 4, 22.

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