Next Article in Journal
Inner Leaf Gel of Aloe striata Induces Adhesion-Reducing Morphological Hyphal Aberrations
Next Article in Special Issue
Special Issue: Mucosal Fungal Infections
Previous Article in Journal
Experimental In Vivo Models of Candidiasis
Previous Article in Special Issue
Anti-Aspergillus Activities of the Respiratory Epithelium in Health and Disease
Open AccessReview

Candida–Epithelial Interactions

Mucosal & Salivary Biology Division, Dental Institute, King’s College London, London SE1 1UL, UK
Author to whom correspondence should be addressed.
J. Fungi 2018, 4(1), 22;
Received: 8 December 2017 / Revised: 4 February 2018 / Accepted: 6 February 2018 / Published: 8 February 2018
(This article belongs to the Special Issue Mucosal Fungal Infections)
PDF [632 KB, uploaded 13 February 2018]


A plethora of intricate and dynamic molecular interactions occur between microbes and the epithelial cells that form the mucosal surfaces of the human body. Fungi, particularly species of Candida, are commensal members of our microbiota, continuously interacting with epithelial cells. Transient and localised perturbations to the mucosal environment can facilitate the overgrowth of fungi, causing infection. This minireview will examine the direct and indirect mechanisms by which Candida species and epithelial cells interact with each other, and explore the factors involved in the central processes of adhesion, invasion, and destruction of host mucosal surfaces. View Full-Text
Keywords: epithelial cell; Candida; fungus; mucosal infection; commensalism; pathogenicity; microbiota epithelial cell; Candida; fungus; mucosal infection; commensalism; pathogenicity; microbiota

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Richardson, J.P.; Ho, J.; Naglik, J.R. Candida–Epithelial Interactions. J. Fungi 2018, 4, 22.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
J. Fungi EISSN 2309-608X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top