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Role of New Antifungal Agents in the Treatment of Invasive Fungal Infections in Transplant Recipients: Isavuconazole and New Posaconazole Formulations
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J. Fungi 2016, 2(1), 2;

Phaeohyphomycosis in Transplant Patients

Division of Infectious Diseases, Department of Medicine, Wayne State University, 3990 John R. Street, 5 Hudson, Detroit, MI 48201, USA
Harper University Hospital, 3990 John R., 5 Hudson, Detroit, MI 48201, USA
Academic Editor: Shmuel Shoham
Received: 13 November 2015 / Revised: 15 December 2015 / Accepted: 17 December 2015 / Published: 22 December 2015
(This article belongs to the Special Issue Fungal Infections in Transplant Recipients)
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Phaeohyphomycosis is caused by a large, heterogenous group of darkly pigmented fungi. The presence of melanin in their cell walls is characteristic, and is likely an important virulence factor. These infections are being increasingly seen in a variety of clinical syndromes in both immunocompromised and normal individuals. Transplant patients are especially at risk due their prolonged immunosuppression. There are no specific diagnostic tests for these fungi, though the Fontana-Masson stain is relatively specific in tissue. They are generally seen in a worldwide distribution, though a few species are only found in specific geographic regions. Management of these infections is not standardized due to lack of clinical trials, though recommendations are available based on clinical experience from case reports and series and animal models. Superficial infections may be treated without systemic therapy. Central nervous system infections are unique in that they often affect otherwise normal individuals, and are difficult to treat. Disseminated infections carry a high mortality despite aggressive therapy, usually with multiple antifungal drugs. Considerable work is needed to determine optimal diagnostic and treatment strategies for these infections. View Full-Text
Keywords: phaeohyphomycosis; voriconazole; itraconazole; posaconazole; transplantation phaeohyphomycosis; voriconazole; itraconazole; posaconazole; transplantation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Revankar, S.G. Phaeohyphomycosis in Transplant Patients. J. Fungi 2016, 2, 2.

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