Next Article in Journal
Rhabdomyosarcoma of the Paranasal Sinuses Initially Diagnosed as Acute Sinusitis
Previous Article in Journal
Contralateral Orbital Mucocele as a Complication of Unilateral Nasal Polyposis
Article Menu

Export Article

From the third issue of 2018, Sinusitis has changed its name to Sinusitis and Asthma.

Open AccessReview
Sinusitis 2017, 2(1), 1;

A Systematic Review of the Treatment of Chronic Rhinosinusitis in Adults with Primary Ciliary Dyskinesia

Department of Otolaryngology—Head and Neck Surgery, Tulane University School of Medicine, New Orleans, LA 70112, USA
Department of Otorhinolaryngology, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
Ochsner Clinical School, University of Queensland School of Medicine, New Orleans, LA 70121, USA
Author to whom correspondence should be addressed.
Academic Editor: César Picado
Received: 1 December 2016 / Revised: 17 January 2017 / Accepted: 17 January 2017 / Published: 26 January 2017
Full-Text   |   PDF [677 KB, uploaded 26 January 2017]   |  


Background: Primary ciliary dyskinesia (PCD) may be an underlying factor in some cases of refractory chronic rhinosinusitis (CRS). However, clinical management of this condition is not well defined. This systematic review examines the available evidence for the diagnosis and management of CRS in adults with PCD. Methods: A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Pubmed, EMBASE, and Cochrane database were queried for studies pertinent to treatment of PCD in adults. Two investigators performed eligibility assessment for inclusion or exclusion in a standardized manner. Results: Of the 278 articles identified, six studies met the criteria for analysis. These studies had a predominately low level of evidence. Medical therapy included oral antibiotics and nasal saline rinses. Endoscopic sinus surgery (ESS) was described in three of six studies. Outcomes measures were limited and included non-validated questionnaires, subjective reporting of CRS symptoms, and decreased preciptins against pseudomonas following ESS. Recommendation for a standardized therapeutic strategy was not possible with the available literature. Conclusion: A paucity of evidence is available to guide the treatment of PCD in the adult population. Further prospective studies are needed to determine the optimal diagnostic and management strategy for this condition. View Full-Text
Keywords: primary ciliary dyskinesia; kartagener’s syndrome; chronic rhinosinusitis primary ciliary dyskinesia; kartagener’s syndrome; chronic rhinosinusitis

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Brunner, J.P.; Riley, C.A.; McCoul, E.D. A Systematic Review of the Treatment of Chronic Rhinosinusitis in Adults with Primary Ciliary Dyskinesia. Sinusitis 2017, 2, 1.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics



[Return to top]
Sinusitis EISSN 2309-107X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top