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Heart Failure in Patients with Preserved Ejection Fraction: Questions Concerning Clinical Progression

Department of Cardiology, University General Hospital AHEPA, Aristotle University, Thessaloniki 54124, Greece
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Academic Editors: Joel D. Schilling and Andy Wessels
J. Cardiovasc. Dev. Dis. 2016, 3(3), 27; https://doi.org/10.3390/jcdd3030027
Received: 26 May 2016 / Revised: 24 August 2016 / Accepted: 2 September 2016 / Published: 8 September 2016
(This article belongs to the Special Issue Heart Failure Pathogenesis and Management)
Over the last two decades, important advances have been made in explaining some pathophysiological aspects of heart failure with preserved ejection fraction (HFpEF) with repercussions for the successful clinical management of the syndrome. Despite these gains, our knowledge for the natural history of clinical progression from the pre-clinical diastolic dysfunction (PDD) until the final clinical stages is significantly limited. The subclinical progression of PDD to the clinical phenotype of HFpEF and the further clinical progression to some more complex clinical models with multi-organ involvement, similar to heart failure with reduced ejection fraction (HFrEF), continue to be poorly understood. Prospective studies are needed to elucidate the natural history of clinical progression in patients with HFpEF and to identify the exact left ventricular remodeling mechanism that underlies this progression. View Full-Text
Keywords: heart failure; heart failure with preserved ejection fraction; left ventricular remodeling; heart failure progression; clinical phenotypes of heart failure heart failure; heart failure with preserved ejection fraction; left ventricular remodeling; heart failure progression; clinical phenotypes of heart failure
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Louridas, G.E.; Lourida, K.G. Heart Failure in Patients with Preserved Ejection Fraction: Questions Concerning Clinical Progression. J. Cardiovasc. Dev. Dis. 2016, 3, 27.

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