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10.3390/jcdd13060226
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Article

Preliminary Outcome of Transcatheter Aortic Valve Implantation at Centers Without On-Site Cardiac Surgery

by
Gianni Dall’Ara
1,2,*,
Miriam Compagnone
1,
Simone Grotti
1,
Andrea Santarelli
3,
Marco Balducelli
4,
Caterina Cavazza
5,
Carlo Savini
2,6,
Carolina Moretti
4,
Filippo Ottani
5,
Andrea Rubboli
4,
Marcello Galvani
7,
Carmine Pizzi
2,8 and
Fabio Felice Tarantino
1
1
Structural Cardiology Unit Forlì-Cesena, Morgagni-Pierantoni Hospital, 47121 Forlì, Italy
2
Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126 Bologna, Italy
3
Cardiology Unit, Bufalini Hospital, 47521 Cesena, Italy
4
Cardiology Unit, Santa Maria delle Croci Hospital, 48121 Ravenna, Italy
5
Cardiology Unit, Infermi Hospital, 47923 Rimini, Italy
6
Cardiovascular Department, Maria Cecilia Hospital, GVM Care & Research, 48033 Cotignola, Italy
7
Cardiovascular Research Unit, Fondazione Cardiologica Sacco, 47121 Forlì, Italy
8
Cardiology Unit, Morgagni-Pierantoni Hospital, 47121 Forlì, Italy
*
Author to whom correspondence should be addressed.
J. Cardiovasc. Dev. Dis. 2026, 13(6), 226; https://doi.org/10.3390/jcdd13060226
Submission received: 4 May 2026 / Revised: 23 May 2026 / Accepted: 25 May 2026 / Published: 27 May 2026
(This article belongs to the Special Issue Transcatheter and Surgical Approaches to Complications of Transcatheter Procedures: Current Trends and Future Challenges, 2nd Edition)
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Abstract

In many countries, patients’ access to transcatheter aortic valve implantation (TAVI) is limited by reimbursement issues or delayed admission to heart valve centers, thus increasing the risk of adverse events in wait-listed patients. The TAVI AT HOME (TAH) is a single-arm, multicenter study aiming to evaluate the safety and efficacy of transfemoral TAVI performed at centers without on-site cardiac surgery by expert operators. The primary endpoint is 30-day all-cause mortality. This study focuses on the run-in phase of the registry, which was required by the ethics committee to perform an interim safety analysis. The outcome of 20 TAH patients enrolled at three Italian centers from May 2023 to May 2024 was compared to 41 TAVI cases included in the permanent local registry, matching the TAH inclusion/exclusion criteria. The two groups had similar baseline characteristics. Significantly more patients in the TAH group were deemed at prohibitive risk (85.0% vs. 56.1%; p = 0.026) but had similar surgical risk scores. A self-expanding device was used in most cases (60.7%). Technical success did not differ between groups (95.0% in the TAH vs. 85.4%, p = 0.409). No deaths at 30 days (primary endpoint) were observed. The 1-year survival rate did not differ between groups. After interim data analysis, the ethics committee authorized the completion of the TAH enrollment and extension to other centers. The TAH approach might represent an alternative model to allow timely access to TAVI without compromising safety and effectiveness.
Keywords: transcatheter aortic valve implantation; transcatheter aortic valve replacement; cardiac surgery; complications; heart team transcatheter aortic valve implantation; transcatheter aortic valve replacement; cardiac surgery; complications; heart team

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MDPI and ACS Style

Dall’Ara, G.; Compagnone, M.; Grotti, S.; Santarelli, A.; Balducelli, M.; Cavazza, C.; Savini, C.; Moretti, C.; Ottani, F.; Rubboli, A.; et al. Preliminary Outcome of Transcatheter Aortic Valve Implantation at Centers Without On-Site Cardiac Surgery. J. Cardiovasc. Dev. Dis. 2026, 13, 226. https://doi.org/10.3390/jcdd13060226

AMA Style

Dall’Ara G, Compagnone M, Grotti S, Santarelli A, Balducelli M, Cavazza C, Savini C, Moretti C, Ottani F, Rubboli A, et al. Preliminary Outcome of Transcatheter Aortic Valve Implantation at Centers Without On-Site Cardiac Surgery. Journal of Cardiovascular Development and Disease. 2026; 13(6):226. https://doi.org/10.3390/jcdd13060226

Chicago/Turabian Style

Dall’Ara, Gianni, Miriam Compagnone, Simone Grotti, Andrea Santarelli, Marco Balducelli, Caterina Cavazza, Carlo Savini, Carolina Moretti, Filippo Ottani, Andrea Rubboli, and et al. 2026. "Preliminary Outcome of Transcatheter Aortic Valve Implantation at Centers Without On-Site Cardiac Surgery" Journal of Cardiovascular Development and Disease 13, no. 6: 226. https://doi.org/10.3390/jcdd13060226

APA Style

Dall’Ara, G., Compagnone, M., Grotti, S., Santarelli, A., Balducelli, M., Cavazza, C., Savini, C., Moretti, C., Ottani, F., Rubboli, A., Galvani, M., Pizzi, C., & Tarantino, F. F. (2026). Preliminary Outcome of Transcatheter Aortic Valve Implantation at Centers Without On-Site Cardiac Surgery. Journal of Cardiovascular Development and Disease, 13(6), 226. https://doi.org/10.3390/jcdd13060226

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