Next Article in Journal
Cor Triatriatum Dexter Associated with an Ostium Primum Atrial Defect and Left-Sided Opening of the Coronary Sinus in a Stillborn Fetus
Next Article in Special Issue
Serum Copper Concentrations, Effect Modifiers and Blood Pressure: Insights from NHANES 2011–2014
Previous Article in Journal
Prevalence, Risk Factors, Prognosis, and Management of Pericardial Effusion in COVID-19
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
JCDD
Volume 10
Issue 9
10.3390/jcdd10090369
jcdd-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Long-Term Prognosis of Different Subtypes of Left Ventricular Noncompaction Cardiomyopathy Patients: A Retrospective Study in China

by
Shiqi Gao
1,†,
Shuyuan Zhang
1,2,†,
Zeyuan Wang
1,
Ming Wu
1,
Chengying Gu
1,
Ruilian Bai
1,
Meixi Liu
1,
Zhuang Tian
1,* and
Shuyang Zhang
1,*
1
Department of Cardiology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100730, China
2
Medical Research Center, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100730, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
J. Cardiovasc. Dev. Dis. 2023, 10(9), 369; https://doi.org/10.3390/jcdd10090369
Submission received: 2 July 2023 / Revised: 20 July 2023 / Accepted: 18 August 2023 / Published: 28 August 2023
(This article belongs to the Special Issue Risk Factors, Diagnosis, and Treatment of Cardiovascular Disease)
Browse Figures
Versions Notes

Abstract

Left ventricular noncompaction (LVNC) is a heterogeneous cardiomyopathy that can be classified into different subtypes based on morphologic and functional features. However, the prognosis of the dilated and isolated subtypes of non-pediatric LVNC remains unknown. We retrospectively studied 101 patients with LVNC diagnosed at Peking Union Medical College Hospital from 2006 to 2022 using the Jenni criteria of transthoracic echocardiography. The patients were grouped into those with dilated LVNC (n = 64) or isolated LVNC (n = 37), and 88 patients (54 with dilated LVNC and 34 with isolated LVNC) were followed up successfully. The primary outcome was major adverse cardiovascular events (a composite of cardiovascular mortality, heart failure, severe ventricular arrhythmia, and systolic embolism). The median follow-up time was 5.24 years. The incidence of major adverse cardiovascular events was 43.2%; patients with dilated LVNC had a higher risk (adjusted hazard ratio, 4.43; 95% confidence interval, 1.24–15.81; p = 0.02) than those with isolated LVNC. None of the isolated LVNC patients had cardiovascular deaths or severe ventricular arrhythmias. The risk of systemic embolism was similar between patients with dilated and isolated LVNC. Our findings indicate that transthoracic echocardiography is a useful tool for classifying LVNC into subtypes with distinct clinical outcomes. Dilated LVNC is associated with a poor prognosis, while the isolated subtype is probably a physiological condition.
Keywords: left ventricular noncompaction (LVNC); transthoracic echocardiography; prognosis; cardiac dilation left ventricular noncompaction (LVNC); transthoracic echocardiography; prognosis; cardiac dilation

Share and Cite

MDPI and ACS Style

Gao, S.; Zhang, S.; Wang, Z.; Wu, M.; Gu, C.; Bai, R.; Liu, M.; Tian, Z.; Zhang, S. Long-Term Prognosis of Different Subtypes of Left Ventricular Noncompaction Cardiomyopathy Patients: A Retrospective Study in China. J. Cardiovasc. Dev. Dis. 2023, 10, 369. https://doi.org/10.3390/jcdd10090369

AMA Style

Gao S, Zhang S, Wang Z, Wu M, Gu C, Bai R, Liu M, Tian Z, Zhang S. Long-Term Prognosis of Different Subtypes of Left Ventricular Noncompaction Cardiomyopathy Patients: A Retrospective Study in China. Journal of Cardiovascular Development and Disease. 2023; 10(9):369. https://doi.org/10.3390/jcdd10090369

Chicago/Turabian Style

Gao, Shiqi, Shuyuan Zhang, Zeyuan Wang, Ming Wu, Chengying Gu, Ruilian Bai, Meixi Liu, Zhuang Tian, and Shuyang Zhang. 2023. "Long-Term Prognosis of Different Subtypes of Left Ventricular Noncompaction Cardiomyopathy Patients: A Retrospective Study in China" Journal of Cardiovascular Development and Disease 10, no. 9: 369. https://doi.org/10.3390/jcdd10090369

APA Style

Gao, S., Zhang, S., Wang, Z., Wu, M., Gu, C., Bai, R., Liu, M., Tian, Z., & Zhang, S. (2023). Long-Term Prognosis of Different Subtypes of Left Ventricular Noncompaction Cardiomyopathy Patients: A Retrospective Study in China. Journal of Cardiovascular Development and Disease, 10(9), 369. https://doi.org/10.3390/jcdd10090369

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop