Cardioneuroablation Using Epicardial Pulsed Field Ablation for the Treatment of Atrial Fibrillation
Abstract
:1. Introduction
2. Pulsed Field Ablation
3. Cardiac Autonomic Nervous System
- The right superior GP (RSGP) is located on the anterosuperior surface of the right atrium, medial to the superior vena cava/right atrium junction and lateral to the aortic root. It is also sometimes known as the aortocaval (SVC-Ao) GP.
- The left superior GP (LSGP) is located at the junction of the left superior pulmonary vein with the posterior left atrium, in the left superolateral area.
- The inferior right and left GPs (IRGP, ILGP) are located at the inferior aspect of the posterior wall of the left atrium, below the right and left PVs. These are sometimes identified as the oblique sinus GP (OSGP).
- The ligament of Marshall also contains autonomic neurons and is considered a target ganglion in this context (LMGP). This is located between the anterior aspect of the left pulmonary veins and the posterior left atrial appendage. It is also known as the vein of Marshall GP (VMGP).
4. Ablation of Ganglionated Plexi—Early Studies
5. Pulsed Field Ablation of Ganglionated Plexi—Pre-Clinical Studies
6. In Vitro Cellular Studies
7. Electric Field Models
8. First-in-Human Clinical Studies
9. Discussion
10. Future Work
10.1. Access
10.2. Localization
10.3. Navigation
10.4. Further Pre-Clinial and Safety Studies
11. Future Applications
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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O’Brien, B.; Reilly, J.; Coffey, K.; González-Suárez, A.; Quinlan, L.; van Zyl, M. Cardioneuroablation Using Epicardial Pulsed Field Ablation for the Treatment of Atrial Fibrillation. J. Cardiovasc. Dev. Dis. 2023, 10, 238. https://doi.org/10.3390/jcdd10060238
O’Brien B, Reilly J, Coffey K, González-Suárez A, Quinlan L, van Zyl M. Cardioneuroablation Using Epicardial Pulsed Field Ablation for the Treatment of Atrial Fibrillation. Journal of Cardiovascular Development and Disease. 2023; 10(6):238. https://doi.org/10.3390/jcdd10060238
Chicago/Turabian StyleO’Brien, Barry, John Reilly, Ken Coffey, Ana González-Suárez, Leo Quinlan, and Martin van Zyl. 2023. "Cardioneuroablation Using Epicardial Pulsed Field Ablation for the Treatment of Atrial Fibrillation" Journal of Cardiovascular Development and Disease 10, no. 6: 238. https://doi.org/10.3390/jcdd10060238