Studies of Genes Involved in Congenital Heart Disease
Abstract
:1. Introduction
2. Transcription Factor TBX5
3. Myosin Heavy Chain Alpha (MYH6)
Gene | CHD type | Reference |
---|---|---|
Transcription factors | ||
TBX5 | ASD, VSD, CD (Holt-oram syndrome) | [6] |
TBX1 | ASD, VSD, TOF, PA (DiGeorge syndrome) | [15] |
TBX20 | ASD, VSD, PFO, MVD | [14] |
GATA4 | ASD, VSD, AVSD | [11] |
GATA6 | PTA, TOF, ASD | [16] |
NKX2.5 | ASD, VSD, SVAS, LVH | [10] |
NKX2.6 | CAT | [17] |
MEF2C | OFT | [13] |
CITED2 | ASD, VSD, PS, TOF | [18] |
IRX4 | VSD | [19] |
ZIC3 | Heterotaxy associted with CHDs | [20] |
SALL4 | Okihiro syndrome/VSD | [21] |
FOXH1 | TOF, TGA, DORV, CAVC, TA | [22] |
FOXP1 | AVSD and HLV | [23] |
ZFPM2/FOG2 | TOF | [24] |
TFAP2B | Char syndrome, PDA | [25] |
Sarcomeric protein | ||
MYH6 | ASD | [32] |
ACTC1 | ASD | [53] |
MYH7 | VSD, LVNC | [47] |
MYH11 | VSD, AA | [48] |
ELN | SVAS, PS, AS | [49] |
4. Cardiac Actin Alpha (ACTC1)
5. Multiple Mutations and Heterozygosity
6. Concluding Remarks
Acknowledgments
Conflicts of Interest
References
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Ghosh, T.K.; Granados-Riveron, J.T.; Buxton, S.; Setchfield, K.; Loughna, S.; Brook, J.D. Studies of Genes Involved in Congenital Heart Disease. J. Cardiovasc. Dev. Dis. 2014, 1, 134-145. https://doi.org/10.3390/jcdd1010134
Ghosh TK, Granados-Riveron JT, Buxton S, Setchfield K, Loughna S, Brook JD. Studies of Genes Involved in Congenital Heart Disease. Journal of Cardiovascular Development and Disease. 2014; 1(1):134-145. https://doi.org/10.3390/jcdd1010134
Chicago/Turabian StyleGhosh, Tushar K., Javier T. Granados-Riveron, Sarah Buxton, Kerry Setchfield, Siobhan Loughna, and J. David Brook. 2014. "Studies of Genes Involved in Congenital Heart Disease" Journal of Cardiovascular Development and Disease 1, no. 1: 134-145. https://doi.org/10.3390/jcdd1010134