Clinical and Pathological Data of 17 Non-Epithelial Pancreatic Tumors in Cats
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Round Cell Tumors, n = 13
3.1.1. Lymphoma, n = 12
3.1.2. Mast Cell Tumor, n = 1
3.2. Spindle Cell Tumors, n = 4
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Marker | Type of Antibody | Source | Dilution | Pretreatment |
---|---|---|---|---|
Vimentin | Monoclonal mouse anti-vimentin (Clone V9) | Dako, Glostrup, Denmark, M0725 | 1:1000 | Peroxidase blocking; steam cook in EDTA buffer |
Smooth muscle actin | Monoclonal mouse anti-human (Clone 1A4) | Dako, Glostrup, Denmark, M0851 | 1:100 | Peroxidase blocking; pressure cook in citrate buffer |
Desmin | Monoclonal mouse anti-human (Clone D33) | Dako, Glostrup, Denmark, M0760 | 1:100 | Peroxidase blocking; steam cook in EDTA buffer |
Von Willebrand factor | Polyclonal rabbit anti-human | Dako, Glostrup, Denmark, A0082 | 1:2000 | Peroxidase blocking; pressure cook in citrate buffer |
CD31 | Monoclonal mouse anti-human (Clone JC70A) | Dako, Glostrup, Denmark, M0823 | 1:100 | Peroxidase blocking; steam cook in EDTA buffer |
CD3 | Monoclonal mouse anti-human (Clone F7.2.38) | Dako, Glostrup, Denmark, M7254 | 1:100 | Peroxidase blocking; steam cook in EDTA buffer |
CD79a | Monoclonal mouse anti-human (Clone HM57) | Bio-Rad Laboratories Inc, Munich, Germany, MCA2538GA | 1:3000 | Peroxidase blocking; steam cook in EDTA buffer |
CD117/c-kit | Polyclonal rabbit anti-human | Dako, Glostrup, Denmark, A4502 | 1:150 | Peroxidase blocking; steam cook in EDTA buffer |
Feline Leukemia Virus gp70 | Monoclonal mouse anti-feline leukemia virus (Clone C11D8) | Bio-Rad Laboratories Inc, Munich, Germany, MCA1897 | 1:200 | Peroxidase blocking; steam cook in EDTA buffer |
Feline Leukemia Virus p27 | Monoclonal mouse anti-feline leukemia virus (Clone PF12J-10A) | Bio-Rad Laboratories Inc, Munich, Germany, MCA2551 | 1:100 | Peroxidase blocking; steam cook in EDTA buffer |
Case No. | Age (years) | Sex | Breed | Clinical Signs | Pancreatic Sample Size (cm) | Diagnosis | Mi/ HPF | Further Infiltrated Organs | Staining, IHC Expression | Survival Time | |
---|---|---|---|---|---|---|---|---|---|---|---|
+ | − | ||||||||||
1 | 1 | MN | DSH | Inappetence, ascites | TS 0.8 × 0.3 × 0.3 | Large BCL | 13 | Kidney, liver, LN | CD79a | CD3, FeLV | 2 months |
2 | 12 | F | SB | Inappetence | CM 3.0 × 3.0 × 3.0 | Large BCL | 5 | Om | CD79a | CD3, FeLV | U |
3 * | 10 | MN | BSH | Vomiting, inappetence, palpable abd. mass | CM 4.0 × 4.0 × 4.0 | Large BCL | 9 | Stomach, mAT | CD79a | CD3, FeLV | Eutha |
4 | 13 | MN | Si | Vomiting, diarrhea | TS 1.0 × 0.4 × 0.3 | Small TCL | 0 | Intestine | CD3 | CD79a, FeLV | 7 months |
5 * | 15 | MN | DSH | Lethargy, painful abd. | TS 1.5 × 1.5 × 1.5 | Intermediate TCL | 0 | Intestine, mLN | CD3, FeLV | CD79a | Eutha |
6 | 11 | F | DSH | Diarrhea | TS 0.3 × 0.3 × 0.3 | Intermediate TCL | 0 | - | CD3 | CD79a | Eutha |
7 * | 16 | MN | DSH | Lethargy, ascites | CP 8.5 × 7.0 × 2.6 | Intermediate TCL | 3 | Intestine, pAT, mLN | CD3 | CD79a, FeLV | Eutha |
8 | 10 | MN | DSH | U | CP 9.0 × 6.0 × 3.0 | Intermediate TCL | 4 | Liver, intestine, mLN | CD3 | CD79a | Eutha |
9 * | 15 | MN | DSH | Lethargy, seizures | CP 7.0 × 6.5 × 0.5 with two masses 0.5 × 0.5 × 0.5 | Large TCL | 1 | Intestine | CD3 | CD79a, FeLV | Eutha |
10 | 11 | M | Cart | U | Two TS 1.0 × 0.5 × 0.1 and 1.1 × 0.5 × 0.4 | Large TCL | 3 | Om, spleen | CD3 | CD79a, FeLV | Eutha |
11 | 8 | FS | DSH | U | Two TS 3.4 × 3.0 × 3.0 and 5.0 × 3.4 × 2.4 | Large TCL | 3 | Intestine, mAT | CD3, FeLV | CD79a | U |
12 * | 10 | MN | DSH | Vomiting, painful abd. | TS 0.4 × 0.4 × 0.4 | Large TCL | 4 | - | CD3 | CD79a, FeLV | U |
13 | 16 | F | BLH | Palpable abd. mass | CM 0.3 × 0.3 × 0.3 and 1.0 × 0.6 × 0.5 | Mast cell tumor | 1 | Spleen | Giemsa | c-kit, FeLV | 2 months |
14 | 13 | FS | DSH | Palpable abd. mass | CM 2.0 × 1.3 × 1.0 | Hemangio-sarcoma | 3 | - | Vim, vWF, CD31 | Eutha | |
15 | 12 | FS | DSH | U | TS 5.5 × 2.0 × 0.4 | Hemangio-sarcoma | 1 | Om, intestine, LN | Vim, CD31, vWF | Eutha | |
16 * | 17 | F | DSH | Palpable abd. mass, lethargy | CP 17.0 × 9.0 × 5.0 with multiple masses up to 2.0 × 2.0 × 2.0 | PS with myofibro-blastic parts | 9 | Om, adherent on capsule of spleen, intestine, liver | Vim, actin | desmin, c-kit | Eutha |
17 | 13 | MN | DSH | Inappetence, ascites | Two TS 1.2 × 0.8 × 0.6 and 3.0 × 3.0 × 2.0 | Fibrosarcoma | 2 | Spleen | Vim | 2 weeks |
Case No. | Diagnosis | fPLI (<3.5 µg/ L) | fTLI (12–82 µg/ L) | DGGR Lipase (<26 U/L) | Alpha Amylase (<1850 U/L) | SAA (<6.7 µg/mL) | Leuko (6.0–11.0 G/L) | Neutro (3.0–11.0 G/L) | Lymph (1.0–4.0 G/L) |
---|---|---|---|---|---|---|---|---|---|
3 | BCL, mild purulent pancreatitis | 4.7 | 30.7 | 25.9 | 922 | 128.83 | 16.1 | 15.0 | 0.6 |
5 | TCL, mild purulent pancreatitis | 4.2 | 25.6 | 30.1 | 552 | 41.06 | |||
9 | TCL, mild purulent pancreatitis | 5.6 | 33.0 | 15.4 | 891 | 47.51 | 11.4 | 9.2 | 1.0 |
12 | TCL, mild purulent pancreatitis | 22.9 | 43.2 | 40.6 | 839 | 62.40 | |||
7 | TCL, mild lymphocytic pancreatitis | >40.0 | 14.1 | 268.7 | 405 | 4.78 | 53.1 | 31.9 | 10.1 |
16 | Pleomorphic sarcoma, mild mixed pancreatitis | 1.8 | 38.5 | 8.7 | 701 | 86.12 | 19.3 | 18.5 | 0.4 |
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Törner, K.; Staudacher, M.; Steiger, K.; Aupperle-Lellbach, H. Clinical and Pathological Data of 17 Non-Epithelial Pancreatic Tumors in Cats. Vet. Sci. 2020, 7, 55. https://doi.org/10.3390/vetsci7020055
Törner K, Staudacher M, Steiger K, Aupperle-Lellbach H. Clinical and Pathological Data of 17 Non-Epithelial Pancreatic Tumors in Cats. Veterinary Sciences. 2020; 7(2):55. https://doi.org/10.3390/vetsci7020055
Chicago/Turabian StyleTörner, Katrin, Marlies Staudacher, Katja Steiger, and Heike Aupperle-Lellbach. 2020. "Clinical and Pathological Data of 17 Non-Epithelial Pancreatic Tumors in Cats" Veterinary Sciences 7, no. 2: 55. https://doi.org/10.3390/vetsci7020055