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Vet. Sci. 2016, 3(4), 27;

Deviant Behavior: Tick-Borne Pathogens and Inflammasome Signaling

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Author to whom correspondence should be addressed.
Academic Editor: Ulrike Munderloh
Received: 1 August 2016 / Revised: 22 September 2016 / Accepted: 23 September 2016 / Published: 28 September 2016
(This article belongs to the Special Issue Comparative Studies in Tick-Borne Diseases in Animals and Humans)
Full-Text   |   PDF [322 KB, uploaded 28 September 2016]


In the face of an assault, host cells mount an immediate response orchestrated by innate immunity. Two of the best described innate immune signaling networks are the Toll- and the Nod-like receptor pathways. Extensive work has been done characterizing both signaling cascades with several recent advances on the forefront of inflammasome biology. In this review, we will discuss how more commonly-studied pathogens differ from tick-transmitted microbes in the context of Nod-like receptor signaling and inflammasome formation. Because pathogens transmitted by ticks have unique characteristics, we offer the opinion that these microbes can be used to uncover novel principles of Nod-like receptor biology. View Full-Text
Keywords: tick-borne diseases; tick-borne pathogens; Nod-like receptors (NLR) tick-borne diseases; tick-borne pathogens; Nod-like receptors (NLR)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Shaw, D.K.; McClure, E.E.; Wang, X.; Pedra, J.H.F. Deviant Behavior: Tick-Borne Pathogens and Inflammasome Signaling. Vet. Sci. 2016, 3, 27.

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