Preliminary Study on Treatment Outcomes and Prednisolone Tapering after Marine Lipid Extract EAB-277 Supplementation in Dogs with Immune-Mediated Hemolytic Anemia
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Chemical Analysis of the Marine Lipid Extract EAB-277
2.2. Animal and Ethical Approval
2.3. Criteria for Case Selection
2.4. Drugs and Dosing Procedures
2.5. Clinical Monitoring and Data Collection
2.6. Calculation of Tapering Regimen
2.7. Statistical Analysis
3. Results
3.1. Lipid Contents of EAB-277
3.2. Baseline Characteristics of Patient Dog with IMHA
3.3. Survival Outcomes
3.4. Post-Therapeutic Clinical Pathology
3.5. Tapering of Immunosuppressive Therapy
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Control Group | Supplement Group | p-Value * | |
---|---|---|---|
Weight † (kg) | 11.15 (5.00–27.65) | 7 (3.55–17.20) | 0.2767 |
Age † (year) | 9 (2.7–11.1) | 8.9 (2.3–11.1) | 0.8589 |
Sex | Male 6 Female 6 | Male 2 Female 4 | 0.6380 |
Hct ‡ (%) | 20.00 ± 8.22 | 21.40 ± 6.23 | 0.7065 |
Hb ‡ (g/dL) | 6.58 ± 2.66 | 6.85 ± 1.84 | 0.8133 |
Spherocytosis # | 2/12 | 4/6 | 0.1070 |
Positive ROFT # | 12/12 | 6/6 | >0.9999 |
Positive saline agglutination test # | 2/12 | 3/6 | 0.2682 |
Positive DAT # | 12/12 | 6/6 | >0.9999 |
Control | Supplement | |
---|---|---|
Eligible animals for tapering | 12.00 | 6.00 |
Tapered animals | 2.00 | 3.00 |
Animal–day at opportunity for tapering | 315.00 | 112.00 |
New tapering per 100 animal–day at opportunity | 0.63 | 2.68 |
Incidence rate difference | 2.05 | |
Incidence rate ratio | 4.2 |
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Mektrirat, R.; Chongrattanameteekul, P.; Pureeroj, N.; Duangboon, M.; Loythong, J.; Wiset, N.; Chantarachart, S.; Lumsangkul, C.; Pongkan, W. Preliminary Study on Treatment Outcomes and Prednisolone Tapering after Marine Lipid Extract EAB-277 Supplementation in Dogs with Immune-Mediated Hemolytic Anemia. Vet. Sci. 2023, 10, 425. https://doi.org/10.3390/vetsci10070425
Mektrirat R, Chongrattanameteekul P, Pureeroj N, Duangboon M, Loythong J, Wiset N, Chantarachart S, Lumsangkul C, Pongkan W. Preliminary Study on Treatment Outcomes and Prednisolone Tapering after Marine Lipid Extract EAB-277 Supplementation in Dogs with Immune-Mediated Hemolytic Anemia. Veterinary Sciences. 2023; 10(7):425. https://doi.org/10.3390/vetsci10070425
Chicago/Turabian StyleMektrirat, Raktham, Peerawit Chongrattanameteekul, Nattanon Pureeroj, Metina Duangboon, Jarunee Loythong, Natakorn Wiset, Sineenart Chantarachart, Chompunut Lumsangkul, and Wanpitak Pongkan. 2023. "Preliminary Study on Treatment Outcomes and Prednisolone Tapering after Marine Lipid Extract EAB-277 Supplementation in Dogs with Immune-Mediated Hemolytic Anemia" Veterinary Sciences 10, no. 7: 425. https://doi.org/10.3390/vetsci10070425