Effect of a Ketogenic Medium Chain Triglyceride-Enriched Diet on the Fecal Microbiota in Canine Idiopathic Epilepsy: A Pilot Study
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Animals and Procedures
Ethics Statement
2.2. Diet
2.3. Fecal Collection and Microbiota Analysis
2.4. Bioinformatics and Statistical Methods
3. Results
3.1. Clinical Outcomes
3.2. Differences in Fecal Microbiota between Epileptic and Non-Epileptic Dogs before and after MCT Diet
3.3. Fecal Microbiota Results in Epileptic Dogs before and after MCT Diet
3.4. Fecal Microbiota Results in Non-Epileptic Dogs before and after MCT Diet
3.5. Differences in Fecal Microbiota between Drug-Refractory and Drug-Sensitive Epileptic Dogs
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Group | Number of Dogs | Males | Females | Age (Years) | Weight D0 (kg) | Weight D30 (kg) | Seizures D0 (per Month) | Seizures D30 (per Month) |
---|---|---|---|---|---|---|---|---|
(%) | Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | |||
NE | (n = 12) | 41.6 | 58.3 | 4.2 ± 2.9 | 14.9 ± 1.8 ab | 13.8 ± 2.2 ab | Not applicable | Not applicable |
E | (n = 11) | 45.5 | 54.5 | 5.6 ± 1.9 | 22.2 ± 17.1 b | 22.2 ± 16.6 b | 2.2 ± 1.6 a | 1.3 ± 1.3 a |
DSE | (n = 6) | 33.3 | 66.7 | 4.7 ± 1.8 | 24.0 ± 22.8 | 24.0 ± 22.2 | 0.8 ± 0.4 | 0.3 ± 0.5 |
DRE | (n = 5) | 60.0 | 40.0 | 6.8 ± 1.8 | 20.0 ± 8.2 | 20.2 ± 8.3 | 3.8 ± 0.4 | 2.4 ± 0.9 |
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García-Belenguer, S.; Grasa, L.; Palacio, J.; Moral, J.; Rosado, B. Effect of a Ketogenic Medium Chain Triglyceride-Enriched Diet on the Fecal Microbiota in Canine Idiopathic Epilepsy: A Pilot Study. Vet. Sci. 2023, 10, 245. https://doi.org/10.3390/vetsci10040245
García-Belenguer S, Grasa L, Palacio J, Moral J, Rosado B. Effect of a Ketogenic Medium Chain Triglyceride-Enriched Diet on the Fecal Microbiota in Canine Idiopathic Epilepsy: A Pilot Study. Veterinary Sciences. 2023; 10(4):245. https://doi.org/10.3390/vetsci10040245
Chicago/Turabian StyleGarcía-Belenguer, Sylvia, Laura Grasa, Jorge Palacio, Jon Moral, and Belén Rosado. 2023. "Effect of a Ketogenic Medium Chain Triglyceride-Enriched Diet on the Fecal Microbiota in Canine Idiopathic Epilepsy: A Pilot Study" Veterinary Sciences 10, no. 4: 245. https://doi.org/10.3390/vetsci10040245