Identification of Ameloblastin as an Amyloid Precursor Protein of Amyloid-Producing Ameloblastoma in Dogs and Cats
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Case Information
2.2. Histopathological Analysis
2.3. Mass-Spectrometry-Based Proteomic Analysis
2.4. Immunohistochemistry (IHC)
3. Results
3.1. Histopathology
3.2. Proteomic Analysis
3.3. Immunohistochemistry
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Case No. | Breed | Age, years | Sex | Region |
---|---|---|---|---|
Dog No. 1 | Toy poodle | 10 | Female | Left mandibular gingival mass |
Dog No.2 | Shih-Tzu | Unknown | Female | Left mandibular mass |
Dog No.3 | Miniature schnauzer | 11 | Male | Right mandibular mass |
Cat No.1 | Mix | 8 | Female | Right maxillary gingival mass |
Cat No.2 | Unknown | 18 | Female | Left maxillary mass |
Case | Ameloblastin | Keratin 5 | Keratin 14 | ApoA-I | ApoA-IV | Vitronectin | Clusterin |
---|---|---|---|---|---|---|---|
Dog No.1 | 844 | 838 | 1274 | - | 65 | 38 | - |
Dog No.2 | 795 | 386 | 408 | 57 | - | - | - |
Dog No.3 | 735 | 822 | 1333 | - | 51 | 197 | 124 |
Cat No.1 | 105 | - | - | - | - | 95 | - |
Cat No.2 | 112 | 399 | 578 | - | - | - | - |
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Masoud, N.S.; Iwaide, S.; Itoh, Y.; Hisada, M.; Harada, T.; Murakami, T. Identification of Ameloblastin as an Amyloid Precursor Protein of Amyloid-Producing Ameloblastoma in Dogs and Cats. Vet. Sci. 2023, 10, 166. https://doi.org/10.3390/vetsci10020166
Masoud NS, Iwaide S, Itoh Y, Hisada M, Harada T, Murakami T. Identification of Ameloblastin as an Amyloid Precursor Protein of Amyloid-Producing Ameloblastoma in Dogs and Cats. Veterinary Sciences. 2023; 10(2):166. https://doi.org/10.3390/vetsci10020166
Chicago/Turabian StyleMasoud, Niki Sedghi, Susumu Iwaide, Yoshiyuki Itoh, Miki Hisada, Tomoyuki Harada, and Tomoaki Murakami. 2023. "Identification of Ameloblastin as an Amyloid Precursor Protein of Amyloid-Producing Ameloblastoma in Dogs and Cats" Veterinary Sciences 10, no. 2: 166. https://doi.org/10.3390/vetsci10020166