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Non-Human Primate Models of Orthopoxvirus Infections

Pathology Unit, German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, 37077 Göttingen, Germany
Author to whom correspondence should be addressed.
Vet. Sci. 2014, 1(1), 40-62;
Received: 23 April 2014 / Revised: 4 June 2014 / Accepted: 5 June 2014 / Published: 10 June 2014
(This article belongs to the Special Issue Animal Models of Disease)
Smallpox, one of the most destructive diseases, has been successfully eradicated through a worldwide vaccination campaign. Since immunization programs have been stopped, the number of people with vaccinia virus induced immunity is declining. This leads to an increase in orthopoxvirus (OPXV) infections in humans, as well as in animals. Additionally, potential abuse of Variola virus (VARV), the causative agent of smallpox, or monkeypox virus, as agents of bioterrorism, has renewed interest in development of antiviral therapeutics and of safer vaccines. Due to its high risk potential, research with VARV is restricted to two laboratories worldwide. Therefore, numerous animal models of other OPXV infections have been developed in the last decades. Non-human primates are especially suitable due to their close relationship to humans. This article provides a review about on non-human primate models of orthopoxvirus infections. View Full-Text
Keywords: non-human primate; smallpox; monkeypox; cowpox; animal models non-human primate; smallpox; monkeypox; cowpox; animal models
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Schmitt, A.; Mätz-Rensing, K.; Kaup, F.-J. Non-Human Primate Models of Orthopoxvirus Infections. Vet. Sci. 2014, 1, 40-62.

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