Surgical Classification for Preclinical Rat Femoral Bone Defect Model: Standardization Based on Systematic Review, Anatomical Analysis and Virtual Surgery
Abstract
:1. Introduction
2. Materials and Methods
2.1. Literature Search Strategy, Criteria, and Study Selection
2.2. Micro-CT Data and Image Processing
3. Results
3.1. Systematic Review of the Literature Search Results
3.2. Establishment of the Surgical Classification System with Exemplar Illustrations
3.2.1. Identification of Anatomical Landmarks with Micro-CT Reconstruction
3.2.2. Definition of Anatomical Locations
3.2.3. Classification of Modeling Methods and Fixation Devices
3.3. Analysis of Potential Surgical Pitfalls
3.4. Detection of Gender-Related Bone Size Difference
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Figure | Classification Code | Detailed Explanation | |||
---|---|---|---|---|---|
Anatomical Region | Surgical Method | Fixation Device | Defect Quantity; Defect Size | ||
7a | II.a-BT.u-NF-(3; 2 mm) | II.a | BT.u: uni-cortical tunnel | NF: no fixation | Quantity: 3; Diameter: 2 mm |
7b | II.b-BT.b-NF-(1; 2 mm) | II.b | BT.b: bi-cortical tunnel | NF: no fixation | Quantity: 1; Diameter: 2 mm |
7c | II.a-CW-NF-(1; 6 mm, 2 mm) | II.a | CW: cortical window | NF: no fixation | Quantity: 1; Length: 6 mm, width: 2 mm |
7d | II.a-SD-IF.PS-(1; 6 mm) | II.a | SD: segmental defect | IF.PS: internal fixation, plate-screw | Quantity: 1; Gap size: 6 mm |
7e | II.a-SD-EF-(1; 6 mm) | II.a | SD: segmental defect | EF: external fixation | Quantity: 1; Gap size: 6 mm |
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Sun, Y.; Helmholz, H.; Willumeit-Römer, R. Surgical Classification for Preclinical Rat Femoral Bone Defect Model: Standardization Based on Systematic Review, Anatomical Analysis and Virtual Surgery. Bioengineering 2022, 9, 476. https://doi.org/10.3390/bioengineering9090476
Sun Y, Helmholz H, Willumeit-Römer R. Surgical Classification for Preclinical Rat Femoral Bone Defect Model: Standardization Based on Systematic Review, Anatomical Analysis and Virtual Surgery. Bioengineering. 2022; 9(9):476. https://doi.org/10.3390/bioengineering9090476
Chicago/Turabian StyleSun, Yu, Heike Helmholz, and Regine Willumeit-Römer. 2022. "Surgical Classification for Preclinical Rat Femoral Bone Defect Model: Standardization Based on Systematic Review, Anatomical Analysis and Virtual Surgery" Bioengineering 9, no. 9: 476. https://doi.org/10.3390/bioengineering9090476