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Article
Peer-Review Record

Clinical Performance Evaluation of a Hyaluronic Acid Dental Gel for the Treatment of Traumatic Ulcers in Patients with Fixed Orthodontic Appliances: A Randomized Controlled Trial

Bioengineering 2022, 9(12), 761; https://doi.org/10.3390/bioengineering9120761
by Marco Tremolati 1, Marco Farronato 1,*, Luca Ferrantino 1, Francesca Rusconi 1, Giovanni Lodi 1 and Cinzia Maspero 1,2
Reviewer 1:
Reviewer 2:
Reviewer 3:
Bioengineering 2022, 9(12), 761; https://doi.org/10.3390/bioengineering9120761
Submission received: 5 October 2022 / Revised: 29 November 2022 / Accepted: 30 November 2022 / Published: 3 December 2022

Round 1

Reviewer 1 Report

Orthodontic wax must still be used for the traumatizing agent to be rounded off. HA gel changes the healing time favorably. I wonder about the product's clinical value in contrast to the statistical one. Otherwise a nice conducted the study. 

Author Response

Please see the attachment

Author Response File: Author Response.docx

Reviewer 2 Report

Dear editor

Thank you for sending MS for revision

The MS discussed the effective use of hyaluronic acid dental gel for the treatment of traumatic ulcers in patients with fixed orthodontic appliances

I still have points 

- I s there any other reported signs such as headache, effect on sleeping habits, reported ulcerbleeding release of inflammatory mediators.

- Is there any patient reported 1st or 2nd infection either in the control group or the treated groups.

The MS requires extensive English editing

 

Author Response

Please see the attachment

Author Response File: Author Response.docx

Reviewer 3 Report

How did you sterilize the rigid plastic ruler?

Wouldn't have been more accurate to use a flexible ruler?

 

When referring to the concern about ulcers in the introduction, the following manuscripts can be cited:

  - Evid Based Dent. 2022 Mar;23(1):40-42. doi: 10.1038/s41432-022-0250-2. Epub 2022 Mar 25. - Med Hypotheses. 2017 Sep;107:22-25. doi: 10.1016/j.mehy.2017.07.013. Epub 2017 Jul 18.

I look forward to reading your corrections.

Author Response

Please see the attachment

Author Response File: Author Response.docx

Round 2

Reviewer 2 Report

Dear authors and editors

The MS still need English editing

Author Response

English language was edited.

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