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Article

Suitable CO2 Solubility Models for Determination of the CO2 Removal Performance of Oxygenators

1
Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, 1060 Vienna, Austria
2
CCORE Technology GmbH, 1040 Vienna, Austria
3
Institute of Engineering Design and Product Development, TU Wien, 1060 Vienna, Austria
4
Department of Anaesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, 1090 Vienna, Austria
*
Author to whom correspondence should be addressed.
Academic Editor: Gou-Jen Wang
Bioengineering 2021, 8(3), 33; https://doi.org/10.3390/bioengineering8030033
Received: 29 January 2021 / Revised: 20 February 2021 / Accepted: 23 February 2021 / Published: 2 March 2021
CO2 removal via membrane oxygenators during lung protective ventilation has become a reliable clinical technique. For further optimization of oxygenators, accurate prediction of the CO2 removal rate is necessary. It can either be determined by measuring the CO2 content in the exhaust gas of the oxygenator (sweep flow-based) or using blood gas analyzer data and a CO2 solubility model (blood-based). In this study, we determined the CO2 removal rate of a prototype oxygenator utilizing both methods in in vitro trials with bovine and in vivo trials with porcine blood. While the sweep flow-based method is reliably accurate, the blood-based method depends on the accuracy of the solubility model. In this work, we quantified performances of four different solubility models by calculating the deviation of the CO2 removal rates determined by both methods. Obtained data suggest that the simplest model (Loeppky) performs better than the more complex ones (May, Siggaard-Anderson, and Zierenberg). The models of May, Siggaard-Anderson, and Zierenberg show a significantly better performance for in vitro bovine blood data than for in vivo porcine blood data. Furthermore, the suitability of the Loeppky model parameters for bovine blood (in vitro) and porcine blood (in vivo) is evaluated. View Full-Text
Keywords: blood oxygenator; carbon dioxide (CO2) removal; carbon dioxide (CO2) solubility model; model performance; model suitability; evaluation; porcine blood; bovine blood blood oxygenator; carbon dioxide (CO2) removal; carbon dioxide (CO2) solubility model; model performance; model suitability; evaluation; porcine blood; bovine blood
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MDPI and ACS Style

Lukitsch, B.; Ecker, P.; Elenkov, M.; Janeczek, C.; Jordan, C.; Krenn, C.G.; Ullrich, R.; Gfoehler, M.; Harasek, M. Suitable CO2 Solubility Models for Determination of the CO2 Removal Performance of Oxygenators. Bioengineering 2021, 8, 33. https://doi.org/10.3390/bioengineering8030033

AMA Style

Lukitsch B, Ecker P, Elenkov M, Janeczek C, Jordan C, Krenn CG, Ullrich R, Gfoehler M, Harasek M. Suitable CO2 Solubility Models for Determination of the CO2 Removal Performance of Oxygenators. Bioengineering. 2021; 8(3):33. https://doi.org/10.3390/bioengineering8030033

Chicago/Turabian Style

Lukitsch, Benjamin, Paul Ecker, Martin Elenkov, Christoph Janeczek, Christian Jordan, Claus G. Krenn, Roman Ullrich, Margit Gfoehler, and Michael Harasek. 2021. "Suitable CO2 Solubility Models for Determination of the CO2 Removal Performance of Oxygenators" Bioengineering 8, no. 3: 33. https://doi.org/10.3390/bioengineering8030033

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