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Bioengineering 2018, 5(4), 97;

Radiotherapy Advances in Pediatric Neuro-Oncology

Department of Radiation Oncology, Unit 97, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Author to whom correspondence should be addressed.
Received: 6 October 2018 / Revised: 26 October 2018 / Accepted: 1 November 2018 / Published: 4 November 2018
(This article belongs to the Special Issue Update in Pediatric Neuro-Oncology)
Full-Text   |   PDF [997 KB, uploaded 4 November 2018]   |  


Radiation therapy (RT) represents an integral component in the treatment of many pediatric brain tumors. Multiple advances have emerged within pediatric radiation oncology that aim to optimize the therapeutic ratio—improving disease control while limiting RT-related toxicity. These include innovations in treatment planning with magnetic resonance imaging (MRI) simulation, as well as increasingly sophisticated radiation delivery techniques. Advanced RT techniques, including photon-based RT such as intensity-modulated RT (IMRT) and volumetric-modulated arc therapy (VMAT), as well as particle beam therapy and stereotactic RT, have afforded an array of options to dramatically reduce radiation exposure of uninvolved normal tissues while treating target volumes. Along with advances in image guidance of radiation treatments, novel RT approaches are being implemented in ongoing and future prospective clinical trials. As the era of molecular risk stratification unfolds, personalization of radiation dose, target, and technique holds the promise to meaningfully improve outcomes for pediatric neuro-oncology patients. View Full-Text
Keywords: radiotherapy; pediatric oncology; brain tumors; proton beam therapy; intensity-modulated radiotherapy; magnetic resonance imaging; image guidance radiotherapy; pediatric oncology; brain tumors; proton beam therapy; intensity-modulated radiotherapy; magnetic resonance imaging; image guidance

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Ludmir, E.B.; Grosshans, D.R.; Woodhouse, K.D. Radiotherapy Advances in Pediatric Neuro-Oncology. Bioengineering 2018, 5, 97.

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