Next Article in Journal
Breast Cancer Estimate Modeling via PDE Thermal Analysis Algorithms
Next Article in Special Issue
The Emerging Role of Amino Acid PET in Neuro-Oncology
Previous Article in Journal / Special Issue
Polo-Like Kinase 4 (PLK4) Is Overexpressed in Central Nervous System Neuroblastoma (CNS-NB)
Article Menu
Issue 4 (December) cover image

Export Article

Open AccessReview
Bioengineering 2018, 5(4), 97; https://doi.org/10.3390/bioengineering5040097

Radiotherapy Advances in Pediatric Neuro-Oncology

Department of Radiation Oncology, Unit 97, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
*
Author to whom correspondence should be addressed.
Received: 6 October 2018 / Revised: 26 October 2018 / Accepted: 1 November 2018 / Published: 4 November 2018
(This article belongs to the Special Issue Update in Pediatric Neuro-Oncology)
Full-Text   |   PDF [997 KB, uploaded 4 November 2018]   |  

Abstract

Radiation therapy (RT) represents an integral component in the treatment of many pediatric brain tumors. Multiple advances have emerged within pediatric radiation oncology that aim to optimize the therapeutic ratio—improving disease control while limiting RT-related toxicity. These include innovations in treatment planning with magnetic resonance imaging (MRI) simulation, as well as increasingly sophisticated radiation delivery techniques. Advanced RT techniques, including photon-based RT such as intensity-modulated RT (IMRT) and volumetric-modulated arc therapy (VMAT), as well as particle beam therapy and stereotactic RT, have afforded an array of options to dramatically reduce radiation exposure of uninvolved normal tissues while treating target volumes. Along with advances in image guidance of radiation treatments, novel RT approaches are being implemented in ongoing and future prospective clinical trials. As the era of molecular risk stratification unfolds, personalization of radiation dose, target, and technique holds the promise to meaningfully improve outcomes for pediatric neuro-oncology patients. View Full-Text
Keywords: radiotherapy; pediatric oncology; brain tumors; proton beam therapy; intensity-modulated radiotherapy; magnetic resonance imaging; image guidance radiotherapy; pediatric oncology; brain tumors; proton beam therapy; intensity-modulated radiotherapy; magnetic resonance imaging; image guidance
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed
Printed Edition Available!
A printed edition of this Special Issue is available here.

Share & Cite This Article

MDPI and ACS Style

Ludmir, E.B.; Grosshans, D.R.; Woodhouse, K.D. Radiotherapy Advances in Pediatric Neuro-Oncology. Bioengineering 2018, 5, 97.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Bioengineering EISSN 2306-5354 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top