Endometrial Stem Cells in Farm Animals: Potential Role in Uterine Physiology and Pathology
AbstractThe endometrium is an accessible source of mesenchymal stem cells. Most investigations of endometrial mesenchymal stem cells (eMSCs) have been conducted in humans. In animals, particularly in livestock, eMSC research is scarce. Such cells have been described in the bovine, ovine, caprine, porcine, and equine endometrium. Here we provide the state of the art of eMSCs in farm animals with a focus on the bovine species. In bovines, eMSCs have been identified during the phases of the estrous cycle, during which their functionality and the presence of eMSC-specific markers has been shown to change. Moreover, postpartum inflammation related to endometritis affects the presence and functionality of eMSCs, and prostaglandin E2 (PGE2) may be the mediator of such changes. We demonstrated that exposure to PGE2 in vitro modifies the transcriptomic profile of eMSCs, showing its potential role in the fate of stem cell activation, migration, and homing during pathological uterine inflammation in endometritis and in healthy puerperal endometrium. Farm animal research on eMSCs can be of great value in translational research for certain uterine pathologies and for immunomodulation of local responses to pathogens, hormones, and other substances. Further research is necessary in areas such as in vivo location of the niches and their immunomodulatory and anti-infective properties. View Full-Text
Share & Cite This Article
Lara, E.; Rivera, N.; Cabezas, J.; Navarrete, F.; Saravia, F.; Rodríguez-Alvarez, L.; Castro, F.O. Endometrial Stem Cells in Farm Animals: Potential Role in Uterine Physiology and Pathology. Bioengineering 2018, 5, 75.
Lara E, Rivera N, Cabezas J, Navarrete F, Saravia F, Rodríguez-Alvarez L, Castro FO. Endometrial Stem Cells in Farm Animals: Potential Role in Uterine Physiology and Pathology. Bioengineering. 2018; 5(3):75.Chicago/Turabian Style
Lara, Evelyn; Rivera, Nathaly; Cabezas, Joel; Navarrete, Felipe; Saravia, Fernando; Rodríguez-Alvarez, Lleretny; Castro, Fidel O. 2018. "Endometrial Stem Cells in Farm Animals: Potential Role in Uterine Physiology and Pathology." Bioengineering 5, no. 3: 75.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.