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Bioengineering 2018, 5(3), 73;

Neurocognitive and Psychosocial Outcomes in Pediatric Brain Tumor Survivors

The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Ann and Robert H. Lurie Children’s Hospital of Chicago and Northwestern Feinberg School of Medicine, Chicago, IL 60611, USA
Author to whom correspondence should be addressed.
Received: 3 August 2018 / Revised: 6 September 2018 / Accepted: 8 September 2018 / Published: 11 September 2018
(This article belongs to the Special Issue Update in Pediatric Neuro-Oncology)
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The late neurocognitive and psychosocial effects of treatment for pediatric brain tumor (PBT) represent important areas of clinical focus and ongoing research. Neurocognitive sequelae and associated problems with learning and socioemotional development negatively impact PBT survivors’ overall health-related quality of life, educational attainment and employment rates. Multiple factors including tumor features and associated complications, treatment methods, individual protective and vulnerability factors and accessibility of environmental supports contribute to the neurocognitive and psychosocial outcomes in PBT survivors. Declines in overall measured intelligence are common and may persist years after treatment. Core deficits in attention, processing speed and working memory are postulated to underlie problems with overall intellectual development, academic achievement and career attainment. Additionally, psychological problems after PBT can include depression, anxiety and psychosocial adjustment issues. Several intervention paradigms are briefly described, though to date research on innovative, specific and effective interventions for neurocognitive late effects is still in its early stages. This article reviews the existing research for understanding PBT late effects and highlights the need for innovative research to enhance neurocognitive and psychosocial outcomes in PBT survivors. View Full-Text
Keywords: pediatric brain tumor; late effects; neurocognitive; cognitive; psychosocial; survivorship pediatric brain tumor; late effects; neurocognitive; cognitive; psychosocial; survivorship

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Stavinoha, P.L.; Askins, M.A.; Powell, S.K.; Pillay Smiley, N.; Robert, R.S. Neurocognitive and Psychosocial Outcomes in Pediatric Brain Tumor Survivors. Bioengineering 2018, 5, 73.

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