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Bioengineering 2018, 5(2), 33; https://doi.org/10.3390/bioengineering5020033

Efficient Computational Design of a Scaffold for Cartilage Cell Regeneration

1
Department of Chemical and Biochemical Engineering, Technical University of Denmark, DK-2800 Kgs., Lyngby, Denmark
2
Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran
*
Author to whom correspondence should be addressed.
Received: 8 March 2018 / Revised: 18 April 2018 / Accepted: 20 April 2018 / Published: 24 April 2018
(This article belongs to the Special Issue Advances in Micro-Bioreactor Design for Organ Cell Studies)
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Abstract

Due to the sensitivity of mammalian cell cultures, understanding the influence of operating conditions during a tissue generation procedure is crucial. In this regard, a detailed study of scaffold based cell culture under a perfusion flow is presented with the aid of mathematical modelling and computational fluid dynamics (CFD). With respect to the complexity of the case study, this work focuses solely on the effect of nutrient and metabolite concentrations, and the possible influence of fluid-induced shear stress on a targeted cell (cartilage) culture. The simulation set up gives the possibility of predicting the cell culture behavior under various operating conditions and scaffold designs. Thereby, the exploitation of the predictive simulation into a newly developed stochastic routine provides the opportunity of exploring improved scaffold geometry designs. This approach was applied on a common type of fibrous structure in order to increase the process efficiencies compared with the regular used formats. The suggested topology supplies a larger effective surface for cell attachment compared to the reference design while the level of shear stress is kept at the positive range of effect. Moreover, significant improvement of mass transfer is predicted for the suggested topology. View Full-Text
Keywords: tissue engineering; CFD simulation; scaffold geometry optimization; micro-bioreactor operating conditions tissue engineering; CFD simulation; scaffold geometry optimization; micro-bioreactor operating conditions
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Tajsoleiman, T.; Abdekhodaie, M.J.; Gernaey, K.V.; Krühne, U. Efficient Computational Design of a Scaffold for Cartilage Cell Regeneration. Bioengineering 2018, 5, 33.

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