Next Article in Journal
Microscale 3D Liver Bioreactor for In Vitro Hepatotoxicity Testing under Perfusion Conditions
Next Article in Special Issue
Smart Wound Dressings for Diabetic Chronic Wounds
Previous Article in Journal
Metabolic Reprogramming and the Recovery of Physiological Functionality in 3D Cultures in Micro-Bioreactors
Previous Article in Special Issue
Topical Digitoxigenin for Wound Healing: A Feasibility Study
Open AccessReview

Stem Cells and Engineered Scaffolds for Regenerative Wound Healing

1
Department of Surgery (Plastic), Yale School of Medicine, New Haven, CT 06510, USA
2
Department of Public Health Studies, Johns Hopkins University, Baltimore, MD 21218, USA
3
Department of Biomedical Engineering, Rutgers University, The State University New Jersey, Piscataway, NJ 08901, USA
4
Department of Surgery (Vascular), Yale School of Medicine, New Haven, CT 06510, USA
*
Authors to whom correspondence should be addressed.
Bioengineering 2018, 5(1), 23; https://doi.org/10.3390/bioengineering5010023
Received: 15 February 2018 / Revised: 5 March 2018 / Accepted: 8 March 2018 / Published: 9 March 2018
(This article belongs to the Special Issue Advances in Wound Healing Systems)
The normal wound healing process involves a well-organized cascade of biological pathways and any failure in this process leads to wounds becoming chronic. Non-healing wounds are a burden on healthcare systems and set to increase with aging population and growing incidences of obesity and diabetes. Stem cell-based therapies have the potential to heal chronic wounds but have so far seen little success in the clinic. Current research has been focused on using polymeric biomaterial systems that can act as a niche for these stem cells to improve their survival and paracrine activity that would eventually promote wound healing. Furthermore, different modification strategies have been developed to improve stem cell survival and differentiation, ultimately promoting regenerative wound healing. This review focuses on advanced polymeric scaffolds that have been used to deliver stem cells and have been tested for their efficiency in preclinical animal models of wounds. View Full-Text
Keywords: chronic wound; scaffold; natural polymer; synthetic polymer; stem cell; surface modification chronic wound; scaffold; natural polymer; synthetic polymer; stem cell; surface modification
Show Figures

Figure 1

MDPI and ACS Style

Dash, B.C.; Xu, Z.; Lin, L.; Koo, A.; Ndon, S.; Berthiaume, F.; Dardik, A.; Hsia, H. Stem Cells and Engineered Scaffolds for Regenerative Wound Healing. Bioengineering 2018, 5, 23.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map

1
Back to TopTop