Encapsulation of Olive Leaves Extracts in Biodegradable PLA Nanoparticles for Use in Cosmetic Formulation

Kesente, Maritina; Kavetsou, Eleni; Roussaki, Marina; Blidi, Slim; Loupassaki, Sofia; Chanioti, Sofia; Siamandoura, Paraskevi; Stamatogianni, Chrisoula; Philippou, Eleni; Papaspyrides, Constantine; Vouyiouka, Stamatina; Detsi, Anastasia

doi:10.3390/bioengineering4030075

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Encapsulation of Olive Leaves Extracts in Biodegradable PLA Nanoparticles for Use in Cosmetic Formulation

¹,

¹,

²,

²,

Paraskevi Siamandoura

³,

Chrisoula Stamatogianni

⁴,

Eleni Philippou

⁴,

Constantine Papaspyrides

⁵,

Stamatina Vouyiouka

⁵ and

Anastasia Detsi

^1,*

Laboratory of Organic Chemistry, School of Chemical Engineering, National Technical University of Athens, Zografou Campus, 15780 Athens, Greece

Department of Food Quality and Chemistry of Natural Products, Mediterranean Agronomic Institute of Chania (Centre International de Hautes Etudes Agronomiques Mediterraneennes), 73100 Chania, Crete, Greece

Laboratory of Food Chemistry and Technology, School of Chemical Engineering, National Technical University of Athens, Zografou Campus, 15780 Athens, Greece

⁴

Korres Natural Products, Drosini 3, 14452 Athens, Greece

⁵

Laboratory of Polymer Technology, School of Chemical Engineering, National Technical University of Athens, Zografou Campus, 15780 Athens, Greece

Author to whom correspondence should be addressed.

Academic Editor: Gary Chinga Carrasco

Bioengineering 2017, 4(3), 75; https://doi.org/10.3390/bioengineering4030075

Received: 11 July 2017 / Revised: 6 September 2017 / Accepted: 7 September 2017 / Published: 12 September 2017

(This article belongs to the Special Issue Novel Biocomposite Engineering and Bio-Applications)

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Abstract

The aim of the current work was to encapsulate olive leaves extract in biodegradable poly(lactic acid) nanoparticles, characterize the nanoparticles and define the experimental parameters that affect the encapsulation procedure. Moreover, the loaded nanoparticles were incorporated in a cosmetic formulation and the stability of the formulation was studied for a three-month period of study. Poly(lactic acid) nanoparticles were prepared by the nanoprecipitation method. Characterization of the nanoparticles was performed using a variety of techniques: size, polydispersity index and ζ-potential were measured by Dynamic Light Scattering; morphology was studied using Scanning Electron Microscopy; thermal properties were investigated using Differential Scanning Calorimetry; whereas FT-IR spectroscopy provided a better insight on the encapsulation of the extract. Encapsulation Efficiency was determined indirectly, using UV-Vis spectroscopy. The loaded nanoparticles exhibited anionic ζ-potential, a mean particle size of 246.3 ± 5.3 nm (Pdi: 0.21 ± 0.01) and equal to 49.2%, while olive leaves extract release from the nanoparticles was found to present a burst effect at the first 2 hours. Furthermore, the stability studies of the loaded nanoparticles’ cosmetic formulation showed increased stability compared to the pure extract, in respect to viscosity, pH, organoleptic characteristics, emulsions phases and grid. View Full-Text

Keywords: olive leaves; encapsulation; nanoparticles; delivery; biodegradable polymers; poly(lactic acid); natural antioxidants; cosmetics

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Kesente, M.; Kavetsou, E.; Roussaki, M.; Blidi, S.; Loupassaki, S.; Chanioti, S.; Siamandoura, P.; Stamatogianni, C.; Philippou, E.; Papaspyrides, C.; Vouyiouka, S.; Detsi, A. Encapsulation of Olive Leaves Extracts in Biodegradable PLA Nanoparticles for Use in Cosmetic Formulation. Bioengineering 2017, 4, 75. https://doi.org/10.3390/bioengineering4030075

AMA Style

Kesente M, Kavetsou E, Roussaki M, Blidi S, Loupassaki S, Chanioti S, Siamandoura P, Stamatogianni C, Philippou E, Papaspyrides C, Vouyiouka S, Detsi A. Encapsulation of Olive Leaves Extracts in Biodegradable PLA Nanoparticles for Use in Cosmetic Formulation. Bioengineering. 2017; 4(3):75. https://doi.org/10.3390/bioengineering4030075

Chicago/Turabian Style

Kesente, Maritina, Eleni Kavetsou, Marina Roussaki, Slim Blidi, Sofia Loupassaki, Sofia Chanioti, Paraskevi Siamandoura, Chrisoula Stamatogianni, Eleni Philippou, Constantine Papaspyrides, Stamatina Vouyiouka, and Anastasia Detsi. 2017. "Encapsulation of Olive Leaves Extracts in Biodegradable PLA Nanoparticles for Use in Cosmetic Formulation" Bioengineering 4, no. 3: 75. https://doi.org/10.3390/bioengineering4030075

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