The Role of Treatment-Related Parameters and Brain Morphology in the Lesion Volume of Magnetic-Resonance-Guided Focused Ultrasound Thalamotomy in Patients with Tremor-Dominant Neurological Conditions
Abstract
:1. Introduction
2. Materials & Methods
2.1. Patients
2.2. CT Protocol
2.3. MRI Scanning Protocols
2.4. MRgFUS Treatment
2.5. Clinical Measures
2.6. Brain Volumetric Quantification
2.7. Lesion Volume Segmentation
2.8. Statistical Analysis
3. Results
3.1. Brain Structural and Radiological Data
3.2. Clinical Data
3.3. Regression Analyses
4. Discussion
Limitations
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Tremor-Dominant Patients (N°36) | Mean ± SD |
---|---|
Normalized GM Volume (cm3) | 326.3 ± 35.3 |
Normalized WM Volume (cm3) | 292.8 ± 41.3 |
Normalized CSF Volume (cm3) | 377.5 ± 49.6 |
Normalized Brain Volume (GM + WM) (cm3) | 619.1 ± 48.4 |
Total Cortical Thickness (mm) | 2.61 ± 0.2 |
Fazekas Scale | 3 [0–7] |
Tremor-Dominant Patients (N°36) | Mean ± SD Values |
---|---|
SDR | 0.49 ± 0.12 |
Skull Area (cm) | 338.6 ± 31.3 |
N° of Transducer Elements | 906.6 ± 66.2 |
N° of Sonications | 6.9 ± 2.1 |
Maximal Watt | 896.3 ± 139.5 |
Maximal Joule | 17673.6 ± 7413.7 |
Maximal Temperature (T°C_max) | 57.4 ± 3.4 |
Maximal Sonication Time (s) | 22.9 ± 7.5 |
ATD | 56 ± 2.9 |
I° Rater | II° Rater | ICC | Mean Dice | |
---|---|---|---|---|
Edema Volume (cm3) | 1607.24 ± 705.5 | 2042.76 ± 895.92 | 0.81 | 0.74 ± 0.13 |
Necrosis Volume (cm3) | 179.31 ± 135.72 | 153.35 ± 118.56 | 0.88 | 0.70 ± 0.11 |
Predictors for Necrosis Volume | ||||||
---|---|---|---|---|---|---|
N° Model | R | R2 | Variable | Standardized β Coefficients | t-Value | p-Value |
Model 1 | 0.484 | 0.234 | N° transducer elements | −0.484 | −3.22 | 0.003 |
Model 2 | 0.595 | 0.354 | N° transducer elements | −0.466 | −3.32 | 0.002 |
T°C_max | 0.346 | 2.47 | 0.02 | |||
Model 3 | 0.664 | 0.44 | N° transducer elements | −0.441 | −3.32 | 0.002 |
T°C_max | 0.345 | 2.61 | 0.01 | |||
Normalized WM Volume | 0.295 | 2.23 | 0.03 | |||
Predictors for Edema Volume | ||||||
Model 1 | 0.508 | 0.258 | T°C_max | 0.508 | 3.44 | 0.002 |
Model 2 | 0.606 | 0.368 | T°C_max | 0.491 | 3.54 | 0.001 |
N° transducer elements | −0.331 | −2.39 | 0.023 |
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Morabito, R.; Cammaroto, S.; Militi, A.; Smorto, C.; Anfuso, C.; Lavano, A.; Tomasello, F.; Di Lorenzo, G.; Brigandì, A.; Sorbera, C.; et al. The Role of Treatment-Related Parameters and Brain Morphology in the Lesion Volume of Magnetic-Resonance-Guided Focused Ultrasound Thalamotomy in Patients with Tremor-Dominant Neurological Conditions. Bioengineering 2024, 11, 373. https://doi.org/10.3390/bioengineering11040373
Morabito R, Cammaroto S, Militi A, Smorto C, Anfuso C, Lavano A, Tomasello F, Di Lorenzo G, Brigandì A, Sorbera C, et al. The Role of Treatment-Related Parameters and Brain Morphology in the Lesion Volume of Magnetic-Resonance-Guided Focused Ultrasound Thalamotomy in Patients with Tremor-Dominant Neurological Conditions. Bioengineering. 2024; 11(4):373. https://doi.org/10.3390/bioengineering11040373
Chicago/Turabian StyleMorabito, Rosa, Simona Cammaroto, Annalisa Militi, Chiara Smorto, Carmelo Anfuso, Angelo Lavano, Francesco Tomasello, Giuseppe Di Lorenzo, Amelia Brigandì, Chiara Sorbera, and et al. 2024. "The Role of Treatment-Related Parameters and Brain Morphology in the Lesion Volume of Magnetic-Resonance-Guided Focused Ultrasound Thalamotomy in Patients with Tremor-Dominant Neurological Conditions" Bioengineering 11, no. 4: 373. https://doi.org/10.3390/bioengineering11040373
APA StyleMorabito, R., Cammaroto, S., Militi, A., Smorto, C., Anfuso, C., Lavano, A., Tomasello, F., Di Lorenzo, G., Brigandì, A., Sorbera, C., Bonanno, L., Ielo, A., Vatrano, M., Marino, S., Cacciola, A., Cerasa, A., & Quartarone, A. (2024). The Role of Treatment-Related Parameters and Brain Morphology in the Lesion Volume of Magnetic-Resonance-Guided Focused Ultrasound Thalamotomy in Patients with Tremor-Dominant Neurological Conditions. Bioengineering, 11(4), 373. https://doi.org/10.3390/bioengineering11040373