Pallidal Recordings in Chronically Implanted Dystonic Patients: Mitigation of Tremor-Related Artifacts
Abstract
:1. Introduction
2. Materials and Methods
2.1. Subjects, Surgery, and Clinical Evaluation
2.2. Experimental Setup and Recordings
2.3. Data Analysis
2.3.1. Data Preprocessing
2.3.2. Spectral Analyses
2.3.3. Assessment of Tremor-Artifacts in LFP Recording and Comparison of IMU vs. EMG Regression Analysis
2.3.4. Evaluation of Pallido-Muscular Coherence with IMU-Regression
2.3.5. Statistical Analysis
3. Results
3.1. Clinical and Demographic Data
3.2. Tremor Contamination of LFP Recordings and Comparison of IMU vs. EMG Regression Analysis
3.3. Pallido-Muscular Coherence after Cleaning
3.4. Sensory Trick and Voluntary Rhythmic Movement
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Patients | DW01 (T+) | DW02 (T+) | DW06 (T+) | DW07 * (T+) | DW08 (T+) | DW03 * (T−) | DW04 * (T−) | DW05 (T−) | |
---|---|---|---|---|---|---|---|---|---|
Sex | F | F | F | F | F | M | M | F | |
Age | 52 | 44 | 57 | 50 | 33 | 74 | 62 | 65 | |
Age at onset, years | 38 | 36 | 42 | Childhood | Childhood | 42 | Childhood | Childhood | |
Age at surgery | 50 | 43 | 56 | 48 ** | 31 | 72 ** | 62 ** | 63 | |
Disease | CD | CD | CD | MFD | DM | CD | DM | DM | |
TWSTRS pre-DBS, score | 18 | 19 | 13 | NA | 22 | 22 | NA | 18 | |
TWSTRS post-DBS, score | Stim-off | 16 | 18 | 8 | 17 | 19 | 16 | 21 | 18 |
TWSTRS post-DBS, score | Stim-on | 15 | 14 | 6 | 8 | NA | 5 | 13 | 6 |
Patient | LFP θ-α Power | LFP θ-α Power EMG Reg (Δ) | LFP θ-α Power IMU Reg (Δ) | LFP-EMG θ-α COH | LFP-EMG θ-α COH—IMU Reg (Δ) |
---|---|---|---|---|---|
DW01 | 17.84 | 17.93 (−0.09) | 15.01 (2.83) | 0.015 | 0.008 (0.007) |
DW02 | 8.16 | 7.03 (1.13) | 4.50 (3.66) | 0.020 | 0.007 (0.013) |
DW06 | 14.34 | 12.85 (1.49) | 9.78 (4.56) | 0.002 | 0.002 (0) |
DW07 | 14.56 | 13.70 (0.86) | 10.59 (3.97) | 0.007 | 0.007 (0) |
DW08 | 6.07 | 2.66 (3.41) | −2.21 (8.28) | 0.010 | 0.002 (0.008) |
DW03 | 16.32 | 16.22 (0.10) | NA | NA | NA |
DW04 | 11.06 | 10.88 (0.18) | NA | NA | NA |
DW05 | 7.33 | 8.00 (0.67) | NA | NA | NA |
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Del Vecchio Del Vecchio, J.; Hanafi, I.; Pozzi, N.G.; Capetian, P.; Isaias, I.U.; Haufe, S.; Palmisano, C. Pallidal Recordings in Chronically Implanted Dystonic Patients: Mitigation of Tremor-Related Artifacts. Bioengineering 2023, 10, 476. https://doi.org/10.3390/bioengineering10040476
Del Vecchio Del Vecchio J, Hanafi I, Pozzi NG, Capetian P, Isaias IU, Haufe S, Palmisano C. Pallidal Recordings in Chronically Implanted Dystonic Patients: Mitigation of Tremor-Related Artifacts. Bioengineering. 2023; 10(4):476. https://doi.org/10.3390/bioengineering10040476
Chicago/Turabian StyleDel Vecchio Del Vecchio, Jasmin, Ibrahem Hanafi, Nicoló Gabriele Pozzi, Philipp Capetian, Ioannis U. Isaias, Stefan Haufe, and Chiara Palmisano. 2023. "Pallidal Recordings in Chronically Implanted Dystonic Patients: Mitigation of Tremor-Related Artifacts" Bioengineering 10, no. 4: 476. https://doi.org/10.3390/bioengineering10040476