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Bioengineering
Volume 10
Issue 2
10.3390/bioengineering10020124
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Review

Vascularized Tissue Organoids

by
Hannah A. Strobel
,
Sarah M. Moss
and
James B. Hoying
*
Advanced Solutions Life Sciences, Manchester, NH 03101, USA
*
Author to whom correspondence should be addressed.
Bioengineering 2023, 10(2), 124; https://doi.org/10.3390/bioengineering10020124
Submission received: 22 December 2022 / Revised: 9 January 2023 / Accepted: 10 January 2023 / Published: 17 January 2023
(This article belongs to the Special Issue 3D Cell Culture in Disease Modeling and Tissue Regeneration)
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Abstract

Tissue organoids hold enormous potential as tools for a variety of applications, including disease modeling and drug screening. To effectively mimic the native tissue environment, it is critical to integrate a microvasculature with the parenchyma and stroma. In addition to providing a means to physiologically perfuse the organoids, the microvasculature also contributes to the cellular dynamics of the tissue model via the cells of the perivascular niche, thereby further modulating tissue function. In this review, we discuss current and developing strategies for vascularizing organoids, consider tissue-specific vascularization approaches, discuss the importance of perfusion, and provide perspectives on the state of the field.
Keywords: organoid; vascularization; spheroid; stem cell; microvessel; vessel; endothelial; vascular network; perfusion; extracellular matrix organoid; vascularization; spheroid; stem cell; microvessel; vessel; endothelial; vascular network; perfusion; extracellular matrix

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MDPI and ACS Style

Strobel, H.A.; Moss, S.M.; Hoying, J.B. Vascularized Tissue Organoids. Bioengineering 2023, 10, 124. https://doi.org/10.3390/bioengineering10020124

AMA Style

Strobel HA, Moss SM, Hoying JB. Vascularized Tissue Organoids. Bioengineering. 2023; 10(2):124. https://doi.org/10.3390/bioengineering10020124

Chicago/Turabian Style

Strobel, Hannah A., Sarah M. Moss, and James B. Hoying. 2023. "Vascularized Tissue Organoids" Bioengineering 10, no. 2: 124. https://doi.org/10.3390/bioengineering10020124

APA Style

Strobel, H. A., Moss, S. M., & Hoying, J. B. (2023). Vascularized Tissue Organoids. Bioengineering, 10(2), 124. https://doi.org/10.3390/bioengineering10020124

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