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Article

Seroprevalence of the Serological Markers of Transfusion-Transmissible Infections among Volunteer Blood Donors of Kosti Obstetrics and Gynecology Hospital

Department of Microbiology, Faculty of Medical Laboratory Sciences, University of El Imam El Mahdi, Kosti 11588, Sudan
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Author to whom correspondence should be addressed.
Academic Editor: William Cho
Medicines 2021, 8(11), 64; https://doi.org/10.3390/medicines8110064
Received: 29 July 2021 / Revised: 9 September 2021 / Accepted: 11 October 2021 / Published: 29 October 2021
(This article belongs to the Special Issue PROTAC—From Bench to Bed)
Background: Transfusion-transmissible infections are well-known global health challenges. The present study is proposed to investigate the seropositivity of anti-HIV1/2, anti-HCV, HBsAg, and anti-T.pallidum among volunteer blood donors of Kosti Obstetrics and Gynecology Hospital. Methods: Our study was conducted in a cross-sectional retrospective manner. The data of donors who attended Kosti Obstetrics and Gynecology Hospital throughout 2016 to 2018 were reviewed and retrieved manually from blood bank records. Results: Out of 8139 donors, 22.52% were seropositive for serological markers of TTIs and 1.67% were seropositive for at least two serological markers of TTIs. The overall seropositivity rate of anti-HIV1/2, HBsAg, anti-HCV, and anti-T.pallidum was 1.77%, 6.07%, 1.14%, and 11.87%, respectively (p < 0.000). Anti-T.pallidum was the most frequently detected (p < 0.05) marker across all study variables. TTIs seroprevalence was significantly (p < 0.05) varied according to the age, residence, occupations, and blood groups. Notably, there was a rising trend in the rate of anti-HIV1/2 and seropositivity for more than one marker with age (p < 0.000). Regionally, rural area residents had a higher rate of anti-HIV1/2 (2.20%), HBsAg (6.31%), anti-HCV (1.42%), anti-T.pallidum (18.38%), and multiple markers seropositivity (2.28%) compared to urban areas. Between occupations, the highest rate of anti-HIV1/2 (p = 0.483), HBsAg (p = 0.003), anti-HCV (p = 0.408), anti-T.pallidum (p < 0.000), and multiple markers seropositivity (p < 0.000) were detected in farmers. Regarding the screening, we also found that the frequency of anti-T.pallidum was significantly (p = 0.003) higher in donors who carry the AB+ve blood group, whereas anti-HCV (1.83%) was more frequent in donors carry O−ve blood group (p = 0.255). As seen, anti-T.pallidum+HBsAg was the most frequently (1.22%) co-occurring markers. In contrast, anti-T.pallidum+anti-HIV1/2+HBsAg was the lowest frequency one (p < 0.000). Conclusions: The study showed an alarming rate of TTIs, which suggests the requirement for comprehensive surveillance and health education programs. View Full-Text
Keywords: anti-HIV1/2; anti-HCV; anti-T.pallidum; HBsAg; TTIs anti-HIV1/2; anti-HCV; anti-T.pallidum; HBsAg; TTIs
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MDPI and ACS Style

Almugadam, B.S.; Ibrahim, O.M.A.; Ahmed, Y.M.A. Seroprevalence of the Serological Markers of Transfusion-Transmissible Infections among Volunteer Blood Donors of Kosti Obstetrics and Gynecology Hospital. Medicines 2021, 8, 64. https://doi.org/10.3390/medicines8110064

AMA Style

Almugadam BS, Ibrahim OMA, Ahmed YMA. Seroprevalence of the Serological Markers of Transfusion-Transmissible Infections among Volunteer Blood Donors of Kosti Obstetrics and Gynecology Hospital. Medicines. 2021; 8(11):64. https://doi.org/10.3390/medicines8110064

Chicago/Turabian Style

Almugadam, Babiker S., Omer M.A. Ibrahim, and Yousif M.A. Ahmed. 2021. "Seroprevalence of the Serological Markers of Transfusion-Transmissible Infections among Volunteer Blood Donors of Kosti Obstetrics and Gynecology Hospital" Medicines 8, no. 11: 64. https://doi.org/10.3390/medicines8110064

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