Seroprevalence of the Serological Markers of Transfusion-Transmissible Infections among Volunteer Blood Donors of Kosti Obstetrics and Gynecology Hospital
Abstract
:1. Introduction
2. Methods
2.1. Study Design, Duration, and Area
2.2. Ethical Consideration
2.3. Study Subjects and Data
2.4. Screening of Anti-HIV1/2, HBsAg, Anti-HCV, and Anti-T.pallidum
2.5. Statistical Analysis
3. Results
3.1. Socio-Demographic Characteristics of Blood Donors
3.2. Seroprevalence of Anti-HIV1/2, Anti-HCV, HBsAg, and Anti-T.pallidum
3.3. Co-Occurrence of Multiple Markers (Serologic Sign of Multiple Infections)
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Badawi, M.M.; Atif, M.S.; Mustafa, Y.Y. Systematic review and meta-analysis of HIV, HBV and HCV infection prevalence in Sudan. Virol. J. 2018, 15, 148. [Google Scholar] [CrossRef] [PubMed]
- Kojima, N.; Klausner, J.D. An Update on the Global Epidemiology of Syphilis. Curr. Epidemiol. Rep. 2018, 5, 24–38. [Google Scholar] [CrossRef] [PubMed]
- GBD 2017 HIV Collaborators. Global, regional, and national incidence, prevalence, and mortality of HIV, 1980–2017, and forecasts to 2030, for 195 countries and territories: A systematic analysis for the Global Burden of Diseases, Injuries, and Risk Factors Study 2017. Lancet HIV 2019, 6, e831–e859. [Google Scholar] [CrossRef] [Green Version]
- Petruzziello, A.; Marigliano, S.; Loquercio, G.; Cozzolino, A.; Cacciapuoti, C. Global epidemiology of hepatitis C virus infection: An up-date of the distribution and circulation of hepatitis C virus genotypes. World J. Gastroenterol. 2016, 22, 7824–7840. [Google Scholar] [CrossRef] [PubMed]
- Jefferies, M.; Rauff, B.; Rashid, H.; Lam, T.; Rafiq, S. Update on global epidemiology of viral hepatitis and preventive strategies. World J. Clin. Cases 2018, 6, 589–599. [Google Scholar] [CrossRef] [PubMed]
- Lavanchy, D.; Kane, M. Global Epidemiology of Hepatitis B Virus Infection. In Hepatitis B Virus in Human Diseases. Molecular and Translational Medicine; Liaw, Y.F., Zoulim, F., Eds.; Humana Press: Cham, Switzerland, 2016; pp. 187–203. [Google Scholar] [CrossRef]
- Shrivastava, S.R.; Shrivastava, P.S.; Ramasamy, J. Thank you for saving my life: Blood donation matters. J. Res. Med Sci. 2016, 21, 23. [Google Scholar] [CrossRef] [PubMed]
- Adu-Poku, F. Seroprevalence of transfusion-transmissible infections among blood donors in the Hohoe Municipality Hospital, Ghana: 2015–2016: A retrospective hospital-based cross-sectional study. PAMJ-Clin. Med. 2020, 2, 12. [Google Scholar]
- Lin, C.K.; Leung, J.N.S.; So, B.K.L.; Lee, C.K. Donor selection for blood safety: Is it still necessary? ISBT Sci. Ser. 2014, 9, 26–29. [Google Scholar] [CrossRef]
- Mbanya, D. Use of quality rapid diagnostic testing for safe blood transfusion in resource-limited settings. Clin. Microbiol. Infect. 2013, 19, 416–421. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Ahmed, E.B.; Essa, A.A.; Almugadam, B.S.; Ahmed, Q.M.; Hussein, M.M. Transfusion transmitted infections among male blood donors of White Nile State, Sudan: Screening of the current seroprevalence and distribution. BMC Res. Notes 2020, 13, 1–6. [Google Scholar] [CrossRef] [PubMed]
- Bazie, E.A.; Ali, M.M.A.; Hamza, H.B.; Magzoub, O.S.; Salih, M.S.M.; Haroun, B.E.; Malik, M.F.K. Sero-Prevalence of HIV and Syphilis Infections among Blood Donors at Kosti Teaching Hospital-White Nile State-Sudan. Int. J. Curr. Microbiol. Appl. Sci. 2015, 4, 832–837. [Google Scholar]
- Abdelaziz, M. Prevalence of Transfusion Transmissible Infection among Healthy Blood Donors at Dongola Specialized Hospital, Sudan, 2010–2015. Sudan J. Med. Sci. 2020, 15, 163–170. [Google Scholar] [CrossRef]
- Ibrahim, M.A.; Adam, N.K.; Adam, M.A.; Abdelrahman, N.A.M.; Erahman, M.A.M.A. Seroprevalence of syphilis antibodies among blood donors at North Darfur State–Sudan, from 2017 to 2019. J. Microbiol. Exp. 2021, 9, 42–45. [Google Scholar]
- Arshad, A.; Borhany, M.; Anwar, N.; Naseer, I.; Ansari, R.; Boota, S.; Fatima, N.; Zaidi, M.; Shamsi, T. Prevalence of transfusion transmissible infections in blood donors of Pakistan. BMC Hematol. 2016, 16, 1–6. [Google Scholar] [CrossRef] [Green Version]
- Keleta, Y.T.; Achila, O.O.; Haile, A.W.; Gebrecherkos, B.H.; Tesfaldet, D.T.; Teklu, K.S.; Mohammed, M.A.; Ghedel, S.T. Seroprevalence of transfusion transmitted infections among blood donors in Gash Barka Zonal Blood Transfusion Center, Barentu, Eritrea, 2014 through 2017. BMC Hematol. 2019, 19, 5. [Google Scholar] [CrossRef] [PubMed]
- Li, C.; Xiao, X.; Yin, H.; He, M.; Li, J.; Dai, Y.; Fu, Y.; Ge, J.; Yang, Y.; Luan, Y.; et al. Prevalence and prev-alence trends of transfusion transmissible infections among blood donors at four Chinese regional blood centers between 2000 and 2010. J. Transl. Med. 2012, 10, 176. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Hang, L.; Zhao, J.; Guo, F.; Ji, H.; Zhang, L.; Jiang, X.; Wang, L. Demographic characteristics of transfusion-transmitted in-fections among blood donors in China. BMC Infect. Dis. 2019, 19, 514. [Google Scholar]
- Mavenyengwa, R.T.; Mukesi, M.; Chipare, I.; Shoombe, E. Prevalence of human immunodeficiency virus, syphilis, hepatitis B and C in blood donations in Namibia. BMC Public Health 2014, 14, 424. [Google Scholar] [CrossRef] [Green Version]
- Pessoni, L.L.; Aquino, É.C.; Alcântara, K.C. Prevalence and trends in transfusion-transmissible infections among blood donors in Brazil from 2010 to 2016. Hematol. Transfus. Cell Ther. 2019, 41, 310–315. [Google Scholar] [CrossRef] [PubMed]
- Abdella, S.; Berheto, T.M.; Tolera, G.; Belete, W.; Deressa, T.; Feleke, A.; H/silassie, A.; Gezahegn, N.; Tadesse, D.; Tefera, M.; et al. Sero-prevalence of transfusion transmittable infections: HIV, Hepatitis B, C and Treponema pallidum and associated factors among blood donors in Ethiopia: A retrospective study. PLoS ONE 2020, 15, e0241086. [Google Scholar] [CrossRef]
- Hroob, A.; Saghir, S.; Almaiman, A.; Alsalahi, O.; Al-Wajeeh, A.; Al-Shargi, O.; Al-Balagi, N.; Mahmoud, A. Prevalence and Association of Transfusion Transmitted Infections with ABO and Rh Blood Groups among Blood Donors at the National Blood Bank, Amman, Jordan. Medicina 2020, 56, 701. [Google Scholar] [CrossRef] [PubMed]
- Quintas, E.; Cogle, A.D.C.; Dias, C.C.; Sebastiao, A.; Pereira, A.D.C.; Sarmento, A.; Cordeiro, L. Prevalence of Syphilis in Blood Donors in Angola from 2011 to 2016. Clin. Med. Rep. 2018, 2, 1–4. [Google Scholar] [CrossRef] [Green Version]
- Ataallah, T.M.; Hanan, K.A.; Maysoun, K.S.; Sadoon, A.A. Prevalence of hepatitis B and C among blood donors attending the National Blood Transfusion Center in Baghdad, Iraq from 2006–2009. Saudi Med. J. 2011, 32, 1046–1050. [Google Scholar]
- Abebe, M.; Alemnew, B.; Biset, S. Prevalence of Hepatitis B Virus and Hepatitis C Virus Among Blood Donors in Nekemte Blood Bank, Western Oromia, Ethiopia: Retrospective 5 Years Study. J. Blood Med. 2020, 11, 543–550. [Google Scholar] [CrossRef]
- Sunderam, S.; Karir, S.; Haider, S.; Singh, S.B.; Kiran, A. Sero-prevalence of transfusion transmitted infections among blood donors at blood bank of Rajendra Institute of Medical Sciences, Ranchi. Healthline J. 2015, 6, 36–40. [Google Scholar]
- Jary, A.; Dienta, S.; Leducq, V.; Le Hingrat, Q.; Cisse, M.; Diarra, A.B.; Fofana, D.B.; Ba, A.; Baby, M.; Achenbach, C.J.; et al. Seroprevalence and risk factors for HIV, HCV, HBV and syphilis among blood donors in Mali. BMC Infect. Dis. 2019, 19, 1–8. [Google Scholar] [CrossRef] [PubMed]
- Heyredin, I.; Mengistie, B.; Weldegebreal, F. Sero-prevalence of transfusion-transmittable infections and associated factors among blood donors in Eastern Ethiopia: An Institutional-based cross-sectional study. SAGE Open Med. 2019, 7, 2050312119834468. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Siraj, N.; Achila, O.O.; Issac, J.; Menghisteab, E.; Hailemariam, M.; Hagos, S.; Gebremeskel, Y.; Tesfamichael, D. Seroprevalence of transfusion-transmissible infections among blood donors at National Blood Transfusion Service, Eritrea: A seven-year retrospective study. BMC Infect. Dis. 2018, 18, 1–9. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Aabdien, M.; Selim, N.; Himatt, S.; Hmissi, S.; Merenkov, Z.; AlKubaisi, N.; Abdel-Rahman, M.E.; Abdelmola, A.; Khelfa, S.; Farag, E.; et al. Prevalence and trends of transfusion transmissible infec-tions among blood donors in the State of Qatar, 2013–2017. BMC Infect. Dis. 2020, 20, 617. [Google Scholar] [CrossRef] [PubMed]
- Hasan, M.; Shammi, T.; Kabir, S. Prevalence of Transfusion Transmissible Infections (HBV, HCV, HIV and Treponema pallidum in Volunteer Blood Donors in Shirajganj District. Bangladesh J. Microbiol. 2020, 36, 105–109. [Google Scholar] [CrossRef]
- Patel, J.; Jansari, T.R.; Chauhan, A. Retrospective Study of Blood Transfusion Transmitted Infections (HIV, HCV, HBV, Syphilis & Malaria] among the Blood Donors in Dhiraj Hospital. Med. Leg. Update 2021, 21, 663–668. [Google Scholar]
- Deka, R.; Gogoi, B.; Brahma, V. Screening of common TTIs in the blood bank of a tertiary care centre—A five years retrospective study. Paripex-Indian J. Res. 2019, 8, 1991–2250. [Google Scholar]
- Mohammed, B.A.B.; Badneen, M.A.; Gibreel, M.O.; Othman, S.A. Prevalence of transfusion-transmissible infections among blood donors in Port Sudan. Egypt. J. Haematol. 2019, 44, 72. [Google Scholar] [CrossRef]
- Cao, W.W.; Zhou, R.R.; Ou, X.; Shi, L.X.; Xiao, C.Q.; Chen, T.Y.; Tan, H.; Fan, X.G.; Li, B.J.; Li, N. Prevalence of hepatitis B virus, hepatitis C virus, human immunodeficiency virus and Treponema pallidum infections in hospitalized patients before transfu-sion in Xiangya hospital Central South University, China from 2011 to 2016. BMC Infect. Dis. 2018, 18, 145. [Google Scholar] [CrossRef] [Green Version]
- Song, Y.; Bian, Y.; Petzold, M.; Ung, C.O. Prevalence and trend of major transfusion-transmissible infections among blood donors in Western China, 2005 through 2010. PLoS ONE 2014, 9, e94528. [Google Scholar] [CrossRef] [PubMed]
- Chandra, T.; Rizvi, S.N.F.; Agarwal, D. Decreasing prevalence of transfusion transmitted infection in Indian scenario. Sci. World J. 2014, 2014, 1–4. [Google Scholar] [CrossRef]
- Prakash, S.; Sahoo, D.; Mishra, D.; Routray, S.; Ray, G.K.; Das, P.K.; Mukherjee, S. Association of transfusion transmitted infections with ABO and Rh D blood group system in healthy blood donors: A retrospective analysis. Int. J. Community Med. Public Heal. 2020, 7, 4444–4448. [Google Scholar] [CrossRef]
- Gao, X.; Cui, Q.; Shi, X.; Su, J.; Peng, Z.; Chen, X.; Lei, N.; Ding, K.; Wang, L.; Yu, R.; et al. Prevalence and trend of hepatitis C virus infection among blood donors in Chinese mainland: A systematic review and meta-analysis. BMC Infect. Dis. 2011, 11, 88. [Google Scholar] [CrossRef] [PubMed] [Green Version]
Variable | Number | Percentage | |
---|---|---|---|
Year | 2016 | 2069 | 25.42 |
2017 | 3132 | 38.48 | |
2018 | 2938 | 36.10 | |
Age group/Years | 18–27 | 4438 | 54.53 |
28–37 | 2982 | 36.64 | |
38–47 | 719 | 8.83 | |
Residence | Urban | 4288 | 52.68 |
Rural | 3851 | 47.32 | |
Occupation | Free businessman | 6234 | 76.60 |
Student | 642 | 7.89 | |
Farmer | 326 | 4.00 | |
Driver | 279 | 3.43 | |
Employee | 287 | 3.53 | |
Policeman | 229 | 2.81 | |
Military man | 142 | 1.74 | |
Blood group and Rhesus type | O+ve | 5510 | 67.70 |
O−ve | 435 | 5.35 | |
A+ve | 1169 | 14.36 | |
A−ve | 159 | 1.95 | |
B+ve | 727 | 8.93 | |
B−ve | 92 | 1.13 | |
AB+ve | 37 | 0.46 | |
AB−ve | 10 | 0.12 |
Variable | Seroprevalence, n (%) | Total of TTIs: n (%) | ||||||
---|---|---|---|---|---|---|---|---|
Anti-HIV1/2 | HBsAg | Anti-HCV | Anti-T.pallidum | Serologic Sign of MI | p Value | |||
Year | 2016 | 18 (0.87) | 116 (5.60) | 22 (1.06) | 223 (10.78) | 33 (1.60) | ˂0.000 | 412 (19.91) |
2017 | 76 (2.42) | 191 (6.10) | 30 (0.96) | 358 (11.43) | 32 (1.02) | ˂0.000 | 687 (21.93) | |
2018 | 50 (1.70) | 187 (6.36) | 41 (1.40) | 385 (13.10) | 71 (2.42) | ˂0.000 | 734 (24.98) | |
p value | ˂0.000 | 0.540 | 0.256 | 0.027 | ˂0.000 | ˂0.000 | ||
Overall | 144 (1.77) | 494 (6.07) | 93 (1.14) | 966 (11.87) | 136 (1.67) | ˂0.000 | 1833 (22.52) |
Variable | TTIs: n (%) | Transfusion-Transmissible Infection: n (%) | ||||||
---|---|---|---|---|---|---|---|---|
Anti-HIV1/2 | HBsAg | Anti-HCV | Anti-T.pallidum | Serologic Sign of MI | p Value | |||
Age group (Years) | 18–27 | 890 (20.05) | 56 (1.26) | 209 (4.70) | 30 (0.67) | 558 (12.57) | 37 (0.83) | ˂0.000 |
28–37 | 757 (25.38) | 64 (2.14) | 243 (8.14) | 52 (1.74) | 331 (11.09) | 67 (2.24) | ˂0.000 | |
38–47 | 186 (25.86) | 24 (3.33) | 42 (5.84) | 11 (1.52) | 77 (10.70) | 32 (4.45) | ˂0.000 | |
p value | ˂0.000 | ˂0.000 | ˂0.000 | ˂0.000 | 0.095 | ˂0.000 | ||
Residence | Urban | 654 (15.25) | 59 (1.37) | 251 (5.85) | 38 (0.88) | 258 (6.01) | 48 (1.11) | ˂0.000 |
Rural | 1179 (30.61) | 85 (2.20) | 243 (6.31) | 55 (1.42) | 708 (18.38) | 88 (2.28) | ˂0.000 | |
p value | ˂0.000 | 0.005 | 0.389 | 0.022 | ˂0.000 | ˂0.000 | ||
Occupation | Free businessman | 1462 (23.45) | 110 (1.76) | 407 (6.52) | 78 (1.25) | 783 (12.56) | 84 (1.34) | ˂0.000 |
Student | 98 (15.26) | 8 (1.24) | 17 (2.64) | 6 (0.93) | 56 (8.72) | 11 (1.71) | ˂0.000 | |
Farmer | 116 (35.58) | 10 (3.06) | 25 (7.66) | 5 (1.53) | 62 (19.01) | 14 (4.29) | ˂0.000 | |
Driver | 56 (20.07) | 6 (2.15) | 15 (5.37) | 2 (0.71) | 22 (7.88) | 11 (3.94) | ˂0.000 | |
Employee | 43 (14.98) | 3 (1.04) | 12 (4.18) | 0 (0) | 21 (7.31) | 7 (2.43) | ˂0.000 | |
Police man | 39 (17.03) | 4 (1.74) | 12 (5.24) | 1 (0.43) | 14 (6.11) | 8 (3.49) | 0.004 | |
Military man | 19 (13.38) | 3 (2.11) | 6 (4.22) | 1 (0.70) | 8 (5.63) | 1 (0.70) | 0.031f | |
p value | ˂0.000 | 0.483f | 0.003 | 0.408f | ˂0.000 | ˂0.000f | ||
Blood group and Rhesus type | O+ve | 1295 (23.50) | 98 (1.77) | 335 (6.07) | 71 (1.28) | 700 (12.70) | 91 (1.65) | ˂0.000 |
O−ve | 94 (21.60) | 7 (1.60) | 32 (7.35) | 8 (1.83) | 36 (8.27) | 11 (2.52) | ˂0.000 | |
A+ve | 241 (20.61) | 17 (1.45) | 71 (6.07) | 8 (0.68) | 124 (10.60) | 21 (1.79) | ˂0.000 | |
A−ve | 46 (28.93) | 7 (4.40) | 13 (8.17) | 2 (1.25) | 20 (12.57) | 4 (2.51) | ˂0.000 | |
B+ve | 124 (17.05) | 14 (1.92) | 32 (4.40) | 4 (0.55) | 66 (9.07) | 8 (1.10) | ˂0.000 | |
B−ve | 21 (22.82) | 0 (0) | 9 (9.78) | 0 (0) | 12 (13.04) | 0 (0) | ˂0.000f | |
AB+ve | 12 (32.43) | 1 (2.70) | 2 (5.40) | 0 (0) | 8 (21.62) | 1 (2.70) | 0.002f | |
AB−ve | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | - | |
p value | ˂0.000f | 0.267f | 0.241f | 0.260f | 0.003f | 0.407f |
Variable | Co-Occurrence: n (%) | ||
---|---|---|---|
Total Donors (n = 8139) | Total Donors with Seropositivity for Multiple Markers (n = 136) | ||
Type of MI | Anti-T.pallidum+Ant-HIV1/2 | 11 (0.13) | 11 (8.09) |
Anti-T.pallidum+HBsAg | 100 (1.22) | 100 (73.53) | |
Anti-T.pallidum+Anti-HCV | 9 (0.11) | 9 (6.62) | |
Anti-HIV1/2+HBsAg | 3 (0.03) | 3 (2.20) | |
Anti-HIV1/2+Anti-HCV | 2 (0.02) | 2 (1.47) | |
HBsAg+Anti-HCV | 5 (0.06) | 5 (3.68) | |
Anti-T.pallidum+Anti-HIV1/2+HBsAg | 1 (0.01) | 1 (0.73) | |
Anti-T.pallidum+HBsAg+Anti-HCV | 5 (0.06) | 5 (3.68) | |
p value | ˂0.000 | ˂0.000 |
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Almugadam, B.S.; Ibrahim, O.M.A.; Ahmed, Y.M.A. Seroprevalence of the Serological Markers of Transfusion-Transmissible Infections among Volunteer Blood Donors of Kosti Obstetrics and Gynecology Hospital. Medicines 2021, 8, 64. https://doi.org/10.3390/medicines8110064
Almugadam BS, Ibrahim OMA, Ahmed YMA. Seroprevalence of the Serological Markers of Transfusion-Transmissible Infections among Volunteer Blood Donors of Kosti Obstetrics and Gynecology Hospital. Medicines. 2021; 8(11):64. https://doi.org/10.3390/medicines8110064
Chicago/Turabian StyleAlmugadam, Babiker Saad, Omer Mohammed Ali Ibrahim, and Yousif Mousa Alobaid Ahmed. 2021. "Seroprevalence of the Serological Markers of Transfusion-Transmissible Infections among Volunteer Blood Donors of Kosti Obstetrics and Gynecology Hospital" Medicines 8, no. 11: 64. https://doi.org/10.3390/medicines8110064
APA StyleAlmugadam, B. S., Ibrahim, O. M. A., & Ahmed, Y. M. A. (2021). Seroprevalence of the Serological Markers of Transfusion-Transmissible Infections among Volunteer Blood Donors of Kosti Obstetrics and Gynecology Hospital. Medicines, 8(11), 64. https://doi.org/10.3390/medicines8110064