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Understanding the Pathological Basis of Neurological Diseases Through Diagnostic Platforms Based on Innovations in Biomedical Engineering: New Concepts and Theranostics Perspectives
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How Nanotechnology and Biomedical Engineering Are Supporting the Identification of Predictive Biomarkers in Neuro-Oncology

Department of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, ON M5T 2S8, Canada
School of Medicine, University of Cagliari, 09124 Cagliari, Italy
National Hospital for Neurology and Neurosurgery, University College London, London WC1N 3BG, UK
School of Medicine, Aristotle University of Thessaloniki, 54623 Thessaloniki, Greece
Fondazione IRCCS IstitutoNeurologico “Carlo Besta”, 20133 Milano, Italy
John Radcliffe Hospital, Oxford University, Oxford OX3 9DU, UK
Division of Neurosurgery, University of Strasbourg, 67000 Strasbourg, France
Author to whom correspondence should be addressed.
Medicines 2018, 5(1), 23;
Received: 25 January 2018 / Revised: 12 February 2018 / Accepted: 22 February 2018 / Published: 26 February 2018
(This article belongs to the Special Issue New Innovations in Biomedical Engineering)
The field of neuro-oncology is rapidly progressing and internalizing many of the recent discoveries coming from research conducted in basic science laboratories worldwide. This systematic review aims to summarize the impact of nanotechnology and biomedical engineering in defining clinically meaningful predictive biomarkers with a potential application in the management of patients with brain tumors. Data were collected through a review of the existing English literature performed on Scopus, MEDLINE, MEDLINE in Process, EMBASE, and/or Cochrane Central Register of Controlled Trials: all available basic science and clinical papers relevant to address the above-stated research question were included and analyzed in this study. Based on the results of this systematic review we can conclude that: (1) the advances in nanotechnology and bioengineering are supporting tremendous efforts in optimizing the methods for genomic, epigenomic and proteomic profiling; (2) a successful translational approach is attempting to identify a growing number of biomarkers, some of which appear to be promising candidates in many areas of neuro-oncology; (3) the designing of Randomized Controlled Trials will be warranted to better define the prognostic value of those biomarkers and biosignatures. View Full-Text
Keywords: biomarkers; precision medicine; innovation; oncology; neurosurgery biomarkers; precision medicine; innovation; oncology; neurosurgery
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Ganau, M.; Paris, M.; Syrmos, N.; Ganau, L.; Ligarotti, G.K.; Moghaddamjou, A.; Prisco, L.; Ambu, R.; Chibbaro, S. How Nanotechnology and Biomedical Engineering Are Supporting the Identification of Predictive Biomarkers in Neuro-Oncology. Medicines 2018, 5, 23.

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