Disintegration Test of Health Food Products Containing Ginkgo Biloba L. or Vitex Agnus-Castus L. in the Japanese Market
Abstract
:1. Introduction
2. Experimental Section
2.1. Materials
Material | Product ID | Category | Distributing Country | Product Form |
---|---|---|---|---|
Ginkgo leaf | gl-B | Health food | Japan | Tablet |
gl-C | ||||
gl-E | Film-coated tablet | |||
gl-F | ||||
gl-G | ||||
gl-J | ||||
gl-A | Soft capsule | |||
gl-I | ||||
gl-D | Hard capsule | |||
gl-H | ||||
gl-K | Pharmaceutical | Germany | Film-coated tablet | |
gl-L | ||||
gl-M | ||||
gl-N | ||||
gl-O | ||||
Chaste tree fruit | cb-D | Health food | Japan | Film-coated tablet |
cb-E | ||||
cb-F | ||||
cb-G | Tablet | |||
cb-J | Capsule | |||
cb-H | U.S.A. | Capsule | ||
cb-I | ||||
cb-K | ||||
cb-A | Pharmaceutical | Germany | Film-coated tablet | |
cb-B | ||||
cb-C | Switzerland |
2.2. Disintegration Test
2.3. Disintegration Test Criteria
3. Results
3.1. Disintegration of the Ginkgo Leaf Products
Product ID | Test Result | Test Time (min) | Time for Disintegration (min) | ||||||
---|---|---|---|---|---|---|---|---|---|
Average | 1 | 2 | 3 | 4 | 5 | 6 | |||
gl-K | ○ | 60 | 15.3 | 14.6 | 14.2 | 14.8 | 14.8 | 17.1 | 16.3 |
gl-L | ○ | 13.6 | 13.7 | 13.7 | 12.9 | 13.7 | 13.3 | 14.3 | |
gl-M | ○ | 14.0 | 13.8 | 13.8 | 13.8 | 13.8 | 14.8 | 13.8 | |
gl-N | ○ | 13.8 | 13.8 | 12.4 | 15.0 | 13.3 | 13.1 | 15.2 | |
gl-O | ○ | 18.0 | 17.7 | 17.7 | 18.5 | 18.5 | 18.5 | 17.3 |
Product ID | Test Result | Test Time (min) | Time for Disintegration (min) | ||||||
---|---|---|---|---|---|---|---|---|---|
Average | 1 | 2 | 3 | 4 | 5 | 6 | |||
gl-B | × | 30 | >60 | >60 | >60 | >60 | >60 | >60 | >60 |
gl-C | × | >60 | >60 | >60 | >60 | >60 | >60 | >60 | |
gl-E | ○ | 60 | 14.9 | 14.4 | 14.4 | 14.4 | 14.5 | 15.4 | 16.1 |
gl-F | × | >60 | >60 | >60 | >60 | >60 | >60 | >60 | |
gl-G | × | >60 | >60 | >60 | >60 | >60 | >60 | >60 | |
gl-J | ○ | 5.6 | 4.0 | 5.3 | 5.3 | 6.1 | 6.1 | 6.6 | |
gl-A | × | 20 | - | 13.0 | 13.0 | 13.0 | >20 | >20 | >20 |
gl-I | ○ | 14.7 | 10.3 | 12.3 | 15.3 | 15.3 | 17.0 | 18.1 | |
gl-D | ○ | 5.9 | 5.3 | 5.5 | 5.5 | 6.1 | 6.2 | 7.0 | |
gl-H | ○ | 4.8 | 4.6 | 4.6 | 4.6 | 4.6 | 5.1 | 5.2 |
3.2. Disintegration of the Chaste Tree Fruit Products
Product ID | Test Result | Test Time (min) | Time for Disintegration (min) | ||||||
---|---|---|---|---|---|---|---|---|---|
Average | 1 | 2 | 3 | 4 | 5 | 6 | |||
cb-A | ○ | 60 | 17.6 | 16.7 | 16.9 | 17.1 | 17.3 | 17.6 | 20.1 |
cb-B | ○ | 15.5 | 13.3 | 14.1 | 15.4 | 15.5 | 15.8 | 19.0 | |
cb-C | ○ | 34.1 | 26.8 | 30.9 | 34.3 | 35.7 | 38.3 | 38.3 |
Product ID | Test Result | Test Time (min) | Time for Disintegration (min) | ||||||
---|---|---|---|---|---|---|---|---|---|
Average | 1 | 2 | 3 | 4 | 5 | 6 | |||
cb-D | ○ | 60 | 45.4 | 44.4 | 45.1 | 45.1 | 45.1 | 45.6 | 46.8 |
cb-E | ○ | 30.0 | 24.4 | 25.4 | 27.1 | 27.7 | 33.7 | 41.4 | |
cb-F | × | >60 | >60 | >60 | >60 | >60 | >60 | >60 | |
cb-G | ○ | 30 | 14.4 | 10.6 | 11.7 | 14.2 | 15.3 | 17.1 | 17.5 |
cb-J | ○ | 20 | 7.9 | 7.5 | 7.5 | 8.0 | 8.0 | 8.2 | 8.2 |
cb-H | × | 22.4 | 14.5 | 18.0 | 19.7 | 22.7 | 22.7 | 37.0 | |
cb-I | ○ | 9.6 | 5.0 | 5.5 | 7.5 | 9.1 | 14.3 | 16.0 | |
cb-K | ○ | 5.3 | 4.8 | 4.8 | 5.3 | 5.3 | 5.7 | 5.7 |
4. Discussion
Acknowledgments
Author Contributions
Conflicts of Interest
References and Notes
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Sato-Masumoto, N.; Masada, S.; Takahashi, S.; Terasaki, S.; Yokota, Y.; Hakamatsuka, T.; Goda, Y. Disintegration Test of Health Food Products Containing Ginkgo Biloba L. or Vitex Agnus-Castus L. in the Japanese Market. Medicines 2015, 2, 47-54. https://doi.org/10.3390/medicines2020047
Sato-Masumoto N, Masada S, Takahashi S, Terasaki S, Yokota Y, Hakamatsuka T, Goda Y. Disintegration Test of Health Food Products Containing Ginkgo Biloba L. or Vitex Agnus-Castus L. in the Japanese Market. Medicines. 2015; 2(2):47-54. https://doi.org/10.3390/medicines2020047
Chicago/Turabian StyleSato-Masumoto, Naoko, Sayaka Masada, Satoshi Takahashi, Sachiko Terasaki, Yoichi Yokota, Takashi Hakamatsuka, and Yukihiro Goda. 2015. "Disintegration Test of Health Food Products Containing Ginkgo Biloba L. or Vitex Agnus-Castus L. in the Japanese Market" Medicines 2, no. 2: 47-54. https://doi.org/10.3390/medicines2020047