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Alterations in Regional Brain Regional Volume Associated with Dioxin Exposure in Men Living in the Most Dioxin-Contaminated Area in Vietnam: Magnetic Resonance Imaging (MRI) Analysis Using Voxel-Based Morphometry (VBM)

1
Department of Public Health, Kanazawa Medical University, Uchinada 920-0293, Japan
2
Biomedical and Pharmaceutical Research Center, Vietnamese Military Medical University, Hanoi 10000, Vietnam
3
Kobe BMA Laboratory, BioView Inc., Kobe 650-0047, Japan
4
Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Jaymie R. Meliker
Toxics 2021, 9(12), 353; https://doi.org/10.3390/toxics9120353
Received: 5 November 2021 / Revised: 12 December 2021 / Accepted: 13 December 2021 / Published: 15 December 2021
(This article belongs to the Special Issue Dioxin and Dioxin-Like Compounds and Human Health)
To clarify the influence of dioxin exposure on brain morphometry, the present study investigated associations between dioxin exposure at high levels and brain structural irregularities in 32 Vietnamese men. Two exposure markers were used: blood dioxin levels, as a marker of exposure in adulthood, and perinatal dioxin exposure, estimated by maternal residency in a dioxin-contaminated area during pregnancy. All subjects underwent brain magnetic resonance imaging (MRI) scans. We analyzed correlations between regional gray matter volumes and blood dioxin levels, and compared regional volumes between men with and without perinatal dioxin exposure using the voxel-based morphometry (VBM) tool from Statistical Parametric Mapping 12 (SPM12). Blood 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was associated with low volume of the medial temporal pole and fusiform gyrus. Toxic equivalency (TEQ)-PCDDs were correlated with low medial temporal pole volume. However, 1,2,3,4,7,8-HxCDD was associated with high middle frontal gyrus and cerebellum volume. In men with perinatal dioxin exposure, the left inferior frontal gyrus pars orbitalis volume was significantly lower than in those without perinatal exposure. These results suggest that dioxin exposure during the perinatal period and in adulthood may alter regional brain volume, which might lead to cognitive deficits and unusual social emotional behavior in Vietnamese men living in dioxin-contaminated areas. View Full-Text
Keywords: dioxin; neuro imaging analysis; brain regional volume; adults; Vietnam dioxin; neuro imaging analysis; brain regional volume; adults; Vietnam
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MDPI and ACS Style

Vu, H.T.; Pham, T.N.; Yokawa, T.; Nishijo, M.; The, T.P.; Do, Q.; Nishino, Y.; Nishijo, H. Alterations in Regional Brain Regional Volume Associated with Dioxin Exposure in Men Living in the Most Dioxin-Contaminated Area in Vietnam: Magnetic Resonance Imaging (MRI) Analysis Using Voxel-Based Morphometry (VBM). Toxics 2021, 9, 353. https://doi.org/10.3390/toxics9120353

AMA Style

Vu HT, Pham TN, Yokawa T, Nishijo M, The TP, Do Q, Nishino Y, Nishijo H. Alterations in Regional Brain Regional Volume Associated with Dioxin Exposure in Men Living in the Most Dioxin-Contaminated Area in Vietnam: Magnetic Resonance Imaging (MRI) Analysis Using Voxel-Based Morphometry (VBM). Toxics. 2021; 9(12):353. https://doi.org/10.3390/toxics9120353

Chicago/Turabian Style

Vu, Hoa T., Thao N. Pham, Takashi Yokawa, Muneko Nishijo, Tai P. The, Quyet Do, Yoshikazu Nishino, and Hisao Nishijo. 2021. "Alterations in Regional Brain Regional Volume Associated with Dioxin Exposure in Men Living in the Most Dioxin-Contaminated Area in Vietnam: Magnetic Resonance Imaging (MRI) Analysis Using Voxel-Based Morphometry (VBM)" Toxics 9, no. 12: 353. https://doi.org/10.3390/toxics9120353

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