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Article
Peer-Review Record

Relationship between Urine Creatinine and Urine Osmolality in Spot Samples among Men and Women in the Danish Diet Cancer and Health Cohort

Toxics 2021, 9(11), 282; https://doi.org/10.3390/toxics9110282
by Selinay Ozdemir 1, Clara G. Sears 2, James M. Harrington 3, Aslak Harbo Poulsen 4, Jessie Buckley 5, Chanelle J. Howe 2, Katherine A. James 6, Anne Tjonneland 4,7, Gregory A. Wellenius 2,8, Ole Raaschou-Nielsen 4,9 and Jaymie Meliker 10,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Toxics 2021, 9(11), 282; https://doi.org/10.3390/toxics9110282
Submission received: 9 October 2021 / Revised: 28 October 2021 / Accepted: 29 October 2021 / Published: 1 November 2021
(This article belongs to the Section Human Toxicology and Epidemiology)

Round 1

Reviewer 1 Report

The development of a urine dilution correction method to replace creatinine or to complement the weaknesses of creatinine is needed, and we believe that this study is highly important.
Please consider the following

Methods
#1. In frozen urines, urinary components precipitate and crystallize. If crystals precipitate in urine, osmolality cannot be measured correctly. How did you avoid this in this study ?

Results
#1. The unit of osmolality is listed as mOsm, but does it mean mOsm/L?
#2. Please show the results of trace element analysis (Median, 25-75%tile).
#3. It may be due to my lack of understanding, but I do not understand how to read Fig.1. The item names (All, Men, etc.) do not match the number of bars in the correlation coefficient.

Author Response

Point-by-point response is provided on the attached. Thank you.

Author Response File: Author Response.docx

Reviewer 2 Report

The research was planned and carried out correctly and the obtained results were discussed very well.
I believe that despite the analytical determinations have been carried out in a reputable institution, the basic validation parameters should be given anyway, it is not absolutely necessary

Author Response

Point-by-point response is provided on the attached. Thank you.

Author Response File: Author Response.docx

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