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Article

Development, Cytotoxicity and Eye Irritation Profile of a New Sunscreen Formulation Based on Benzophenone-3-poly(ε-caprolactone) Nanocapsules

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University of Tiradentes (Unit), Biotechnological Postgraduate Program. Av. MuriloDantas, 300, Aracaju 49010-390, Brazil
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Institute of Technology and Research (ITP), Nanomedicine and Nanotechnology Laboratory (LNMed), Av. Murilo Dantas, 300, Aracaju 49010-390, Brazil
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Department of Morphology, Federal University of Sergipe (UFS), Avenida Marechal Rondon, São Cristovão 49100-000, Brazil
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Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal
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Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, v.v.i., Heyrovsky Sq. 2, 162 06 Prague, Czech Republic
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Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, and Institute of Nanoscience and Nanotechnology (IN2UB), Faculty of Pharmacy, University of Barcelona, 08028 Barcelona, Spain
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CEB—Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal
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Tiradentes Institute, 150 Mt Vernon St, Dorchester, MA 02125, USA
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Authors to whom correspondence should be addressed.
Toxics 2019, 7(4), 51; https://doi.org/10.3390/toxics7040051
Received: 30 August 2019 / Revised: 18 September 2019 / Accepted: 19 September 2019 / Published: 22 September 2019
(This article belongs to the Section Risk Assessment and Management)
The objective of this work was to characterize the toxicological profile of a newly developed sunscreen formulation based on polymeric nanocapsules (NCs) loading benzophenone-3 (BZP3). NCs composed of poly(ε-caprolactone) carrot oil and Pluronic® F68 were produced by emulsification-diffusion method. Their mean particle size (Z-Ave) ranged from 280 to 420 nm, polydispersity index (PDI) was below 0.37, while zeta potential (ZP) reached about |+11 mV|. No cytotoxic effects were observed in L929 fibroblast cell line for the blank (i.e., non-loaded) NCs and BZP3-loaded NCs (BZP3-NCs). The semi-solid sunscreen formulation was stable over time (centrifugation testing) and exhibited non-Newtonian pseudoplastic behavior, which is typical of products for topical application onto the skin. The sun protection factor (SPF) value reached 8.84, when incorporating BZP3-NCs (SPF of 8.64) into the semi-solid formulation. A synergistic effect was also observed when combining the formulation ingredients of nanocapsules, i.e., SPF of carrot oil was 6.82, blank NCs was 6.84, and BZP3-loaded NCs was 8.64. From the hen’s egg-chorioallantoic membrane test (HET-CAM) test, the non-irritation profile of the developed formulations could also be confirmed. The obtained results show a promising use of poly(ε-caprolactone) nanocapsules to be loaded with lipophilic sunscreens as benzophenone-3. View Full-Text
Keywords: polymeric nanocapsules; poly(ε-caprolactone); benzophenone-3; sunscreen; cytotoxicity; ocular tolerance polymeric nanocapsules; poly(ε-caprolactone); benzophenone-3; sunscreen; cytotoxicity; ocular tolerance
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MDPI and ACS Style

Barbosa, T.C.; Nascimento, L.É.D.; Bani, C.; Almeida, T.; Nery, M.; Santos, R.S.; Menezes, L.R.d.O.; Zielińska, A.; Fernandes, A.R.; Cardoso, J.C.; Jäger, A.; Jäger, E.; Sanchez-Lopez, E.; Nalone, L.; Souto, E.B.; Severino, P. Development, Cytotoxicity and Eye Irritation Profile of a New Sunscreen Formulation Based on Benzophenone-3-poly(ε-caprolactone) Nanocapsules. Toxics 2019, 7, 51. https://doi.org/10.3390/toxics7040051

AMA Style

Barbosa TC, Nascimento LÉD, Bani C, Almeida T, Nery M, Santos RS, Menezes LRdO, Zielińska A, Fernandes AR, Cardoso JC, Jäger A, Jäger E, Sanchez-Lopez E, Nalone L, Souto EB, Severino P. Development, Cytotoxicity and Eye Irritation Profile of a New Sunscreen Formulation Based on Benzophenone-3-poly(ε-caprolactone) Nanocapsules. Toxics. 2019; 7(4):51. https://doi.org/10.3390/toxics7040051

Chicago/Turabian Style

Barbosa, Thallysson C., Lívia É.D. Nascimento, Cristiane Bani, Taline Almeida, Marcelo Nery, Rafael S. Santos, Luana R.d.O. Menezes, Aleksandra Zielińska, Ana R. Fernandes, Juliana C. Cardoso, Alessandro Jäger, Eliezer Jäger, Elena Sanchez-Lopez, Luciana Nalone, Eliana B. Souto, and Patrícia Severino. 2019. "Development, Cytotoxicity and Eye Irritation Profile of a New Sunscreen Formulation Based on Benzophenone-3-poly(ε-caprolactone) Nanocapsules" Toxics 7, no. 4: 51. https://doi.org/10.3390/toxics7040051

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