Differences of Clinical Characteristics and Drug Prescriptions between Men and Women with COPD in China
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Data Source
2.2. Participants
2.3. Exposure History
2.4. Exacerbations
2.5. Statistical Analysis
2.6. Patient and Public Involvement
3. Results
3.1. Baseline and Clinical Characteristics
3.2. Drug Prescriptions
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Baseline Clinical Characteristics | Men n = 1462 | Missing Data | Women n = 731 | Missing Data | p-Value |
---|---|---|---|---|---|
Age (year), mean ± SD | 64.4 ± 9.4 | 0 (0) | 64.45 ± 9.7 | 0 (0) | - |
Male, n (%) | - | - | - | - | |
BMI (kg/m2), mean ± SD | 22.8 ± 3.5 | 0 (0) | 22.9 ± 4.0 | 0 (0) | - |
Educational level, n (%) | 51 (3.5) | 40 (5.5) | <0.001 | ||
Primary school or below | 611 (43.3) | 410 (59.3) | |||
Middle school | 523 (37.1) | 186 (26.9) | |||
High school | 201 (14.2) | 73 (10.6) | |||
College or above | 76 (5.4) | 22 (3.2) | |||
Marital status, n (%) | 43 (2.9) | 36 (4.9) | <0.001 | ||
Unmarried | 12 (.8) | 4 (.6) | |||
Married | 1346 (94.9) | 611 (87.9) | |||
Divorced | 5 (.4) | 5 (.7) | |||
Widowhood | 56 (3.9) | 75 (10.8) | |||
Smoking history, n (%) | 49 (3.4) | 91 (12.4) | <0.001 | ||
Never smoker | 153 (10.8) | 576 (90.0) | |||
Former smoker | 595 (42.1) | 29 (4.5) | |||
Current smoker | 665 (47.1) | 35 (5.5) | |||
Occupational exposure (n, %) | 539 (36.9) | 114 (7.8) | 84 (11.5) | 59 (8.1) | <0.001 |
Exposure time (h-y) | 120 (60, 240) | 80 (50, 180) | 0.013 | ||
Biomass exposure (n, %) | 392 (26.8) | 108 (7.4) | 330 (45.1) | 54 (7.4) | <0.001 |
Exposure time (h-y) | 60 (30, 100) | 70 (40, 120) | 0.004 | ||
Lung function, mean ± SD | 0 (0) | 0 (0) | |||
FEV1% predicted | 57.0 ± 21.8 | 57.1 ± 22.0 | - | ||
FEV1/FVC% | 52.4 ± 12.5 | 55.0 ±12.6 | <0.001 | ||
CAT, mean ± SD | 15.1 ± 6.8 | 46 (3.1) | 16.5 ±6.7 | 42 (5.7) | <0.001 |
<10 points | 306 (21.6) | 104 (15.1) | |||
10–20 points | 760 (53.7) | 363 (52.7) | |||
≥20 points | 350 (24.7) | 222 (32.2) | |||
mMRC dyspnea grade, median (IQR) | 2 (1–2) | 46 (3.1) | 2 (1–3) | 42 (5.7) | 0.03 |
0 or 1 | 505 (35.7) | 234 (34.0) | |||
≥2 | 911 (64.3) | 455 (66.0) | |||
Exacerbation history in last one year, median (IQR) | 1 (0–2) | 80 (5.5) | 1 (0–2) | 75 (10.3) | 0.174 |
CAT, Median (IQR) | Men n = 1416 | Women n = 689 | p-Value |
---|---|---|---|
CAT1-Cough | 2 (1–3) | 2 (1–3) | 0.041 |
CAT2-Phlegm | 2 (1–3) | 2 (1–3) | 0.141 |
CAT3-Chest tightness | 2 (1–3) | 2 (1–3) | 0.291 |
CAT4-Breathlessness | 2 (1–3) | 2 (1–4) | <0.001 |
CAT5-Activities | 2 (1–3) | 3 (2–3) | 0.038 |
CAT6-Confidence | 0 (0–2) | 1 (0–2) | <0.001 |
CAT7-Sleep | 1 (0–3) | 2 (1–3) | <0.001 |
CAT8-Energy | 2 (1–3) | 3 (2–3) | 0.038 |
Therapies, Only Used, n (%) | Men n = 1251 | Women n = 650 | p-Value |
---|---|---|---|
Mono therapy | 517 (41.33) | 229 (35.23) | 0.010 |
SABA | 21 | 1 | |
SAMA | 5 | 1 | |
LABA | 0 | 0 | |
LAMA | 490 | 226 | |
ICS | 1 | 1 | |
Dual therapy | 273 (21.82) | 153 (23.54) | 0.395 |
LABA/ICS | 162 | 110 | |
LAMA/LABA | 109 | 43 | |
LAMA + ICS | 2 | 0 | |
Triple therapy | 388 (31.02) | 236 (36.31) | 0.020 |
LABA/LAMA/ICS | 50 | 17 | |
LABA/LAMA + ICS | 1 | ||
LAMA + LABA/ICS | 338 | 218 | |
Other therapies | 73 (5.84) | 32 (4.92) | 0.409 |
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Zeng, Y.; Spruit, M.A.; Deng, Q.; Franssen, F.M.E.; Chen, P. Differences of Clinical Characteristics and Drug Prescriptions between Men and Women with COPD in China. Toxics 2023, 11, 102. https://doi.org/10.3390/toxics11020102
Zeng Y, Spruit MA, Deng Q, Franssen FME, Chen P. Differences of Clinical Characteristics and Drug Prescriptions between Men and Women with COPD in China. Toxics. 2023; 11(2):102. https://doi.org/10.3390/toxics11020102
Chicago/Turabian StyleZeng, Yuqin, Martijn A Spruit, Qichen Deng, Frits M. E. Franssen, and Ping Chen. 2023. "Differences of Clinical Characteristics and Drug Prescriptions between Men and Women with COPD in China" Toxics 11, no. 2: 102. https://doi.org/10.3390/toxics11020102