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Open AccessArticle

Ginger Water Reduces Body Weight Gain and Improves Energy Expenditure in Rats

1
Department of Biotechnology, Faculty of Science, Taif University, Taif 21974, Saudi Arabia
2
Faculty of Agriculture, Cairo University, Giza 12613, Egypt
3
Faculty of Veterinary Medicine, University of Sadat City, Sadat City 32958, Egypt
4
Department of Genetics, Faculty of Agriculture, University of Alexandria, Alexandria 21526, Egypt
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Department of Nutrition and Clinical Nutrition, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh 33516, Egypt
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Department of Biochemistry, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafr Elsheikh 33511, Egypt
*
Author to whom correspondence should be addressed.
Foods 2020, 9(1), 38; https://doi.org/10.3390/foods9010038
Received: 19 November 2019 / Revised: 26 December 2019 / Accepted: 30 December 2019 / Published: 2 January 2020
(This article belongs to the Special Issue Nutraceuticals in Human Health)
Obesity is a serious global problem that causes predisposition to numerous serious diseases. The current study aims to investigate the effect of ginger water on body weight and energy expenditure through modulation of mRNA expression of carbohydrate and lipid metabolism. A white colored liquid obtained during freeze-drying of fresh rhizomes of Zingiber officinal was collected and named ginger water. It was used to treat rats, then blood and tissue samples were collected from the liver and white adipose at the end of the experiment. The serum was prepared and used for biochemical assays, while tissue samples were used for RNA isolation and gene expression analysis via Reverse transcription polymerase chain reaction (RT-PCR). Results of High Performance Liquid Chromatography (HPLC) analysis of ginger water revealed the presence of chrysin and galangin at concentrations of 0.24 µg/mL and 0.53 µg/mL, respectively. Average body weight gain decreased significantly in groups that received ginger water. In addition, both total cholesterol and serum triacylglycerol were reduced in the groups that received ginger water. Furthermore, mRNA expression of Sterol regulatory element-binding protein 1 (SREBP-1c) in the liver and leptin in adipose tissues were downregulated, while those of adiponectin, hepatic carnitine palmitoyltransferase1 (CPT-1), acyl-coA oxidase (ACO), Glucose transporter 2 (GLUT-2), and pyruvate kinase (PK) were upregulated in ginger water-treated groups. These results clearly revealed the lowering body weight gain effect of ginger water, which most likely occurs at the transcriptional level of energy metabolizing proteins. View Full-Text
Keywords: ginger water; obesity; energy homeostasis; gene expression; rat ginger water; obesity; energy homeostasis; gene expression; rat
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Sayed, S.; Ahmed, M.; El-Shehawi, A.; Alkafafy, M.; Al-Otaibi, S.; El-Sawy, H.; Farouk, S.; El-Shazly, S. Ginger Water Reduces Body Weight Gain and Improves Energy Expenditure in Rats. Foods 2020, 9, 38.

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