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Article

Process Simulation and Techno-Economic Analysis of Large-Scale Bioproduction of Sweet Protein Thaumatin II

1
Department of Chemical Engineering, University of California, Davis, CA 95616, USA
2
DT/Consulting Group, Sacramento, CA 95818, USA
3
Nomad Bioscience GmbH, 06120 Halle, Germany
4
Global HealthShare® Initiative, University of California, Davis, CA 95616, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Amit K. Jaiswal
Foods 2021, 10(4), 838; https://doi.org/10.3390/foods10040838
Received: 2 March 2021 / Accepted: 8 April 2021 / Published: 12 April 2021
There are currently worldwide efforts to reduce sugar intake due to the various adverse health effects linked with the overconsumption of sugars. Artificial sweeteners have been used as an alternative to nutritive sugars in numerous applications; however, their long-term effects on human health remain controversial. This led to a shift in consumer preference towards non-caloric sweeteners from natural sources. Thaumatins are a class of intensely sweet proteins found in arils of the fruits of the West-African plant Thaumatococcus daniellii. Thaumatins’ current production method through aqueous extraction from this plant and uncertainty of the harvest from tropical rainforests limits its supply while the demand is increasing. Despite successful recombinant expression of the protein in several organisms, no large-scale bioproduction facilities exist. We present preliminary process design, process simulation, and economic analysis for a large-scale (50 metric tons/year) production of a thaumatin II variant using several different molecular farming platforms. View Full-Text
Keywords: thaumatin; sweet protein; molecular farming; natural sweeteners thaumatin; sweet protein; molecular farming; natural sweeteners
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MDPI and ACS Style

Kelada, K.D.; Tusé, D.; Gleba, Y.; McDonald, K.A.; Nandi, S. Process Simulation and Techno-Economic Analysis of Large-Scale Bioproduction of Sweet Protein Thaumatin II. Foods 2021, 10, 838. https://doi.org/10.3390/foods10040838

AMA Style

Kelada KD, Tusé D, Gleba Y, McDonald KA, Nandi S. Process Simulation and Techno-Economic Analysis of Large-Scale Bioproduction of Sweet Protein Thaumatin II. Foods. 2021; 10(4):838. https://doi.org/10.3390/foods10040838

Chicago/Turabian Style

Kelada, Kirolos D., Daniel Tusé, Yuri Gleba, Karen A. McDonald, and Somen Nandi. 2021. "Process Simulation and Techno-Economic Analysis of Large-Scale Bioproduction of Sweet Protein Thaumatin II" Foods 10, no. 4: 838. https://doi.org/10.3390/foods10040838

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