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Article

Adjunctive Antiseptic Irrigation of Periodontal Pockets: Effects on Microbial and Cytokine Profiles

1
Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, 14152 Huddinge, Sweden
2
First Department of Therapeutic Dentistry, Belarusian State Medical University, 220045 Minsk, Belarus
3
Department of Bioorganic Chemistry, Belarusian State Medical University, 220045 Minsk, Belarus
4
Department of Microbiology, Virology and Immunology, Belarusian State Medical University, 220045 Minsk, Belarus
5
Department of Oral and Maxillofacial Diseases, Institute of Dentistry, University of Helsinki, 00290 Helsinki, Finland
*
Author to whom correspondence should be addressed.
Dent. J. 2020, 8(4), 124; https://doi.org/10.3390/dj8040124
Received: 16 August 2020 / Revised: 30 September 2020 / Accepted: 19 October 2020 / Published: 2 November 2020
(This article belongs to the Section Oral Hygiene, Periodontology and Peri-implant Diseases)
To evaluate the effect of adjunctive antiseptic irrigation of periodontal pockets on microbial and cytokine profiles. Fifty-nine patients with severe periodontitis were allocated to one of three groups for scaling and root planing facilitated with different adjunctive antiseptics: 1% polyhexamethyleneguanidine phosphate (PHMG-P) (n = 19), 0.2% chlorhexidine (CHX) (n = 21) or distilled water (n = 19). Gingival crevicular fluid and subgingival bacterial samples were collected at baseline, and at 2 weeks, and 1 and 4 months. The levels of interleukin (IL)-1β, IL-8, IL-10, and IL-17A, matrix metalloproteinase (MMP)-8, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Fusobacterium nucleatum,Aggregatibacter actinomycetemcomitans, and Prevotella intermedia were determined. There were no intergroup differences in cytokine concentrations and bacterial counts at any follow-up, however, varying patterns were observed. In the PHMG-P and water groups IL-1β expression peaked at 2 weeks and then gradually declined. In all three groups, the dynamics of MMP-8 concentration were non-linear, increasing by 2 weeks and then declining to below baseline (p > 0.05). P. gingivalis and T. forsythia declined within the first month and increased thereafter, not regaining the baseline level. Adjunctive antiseptic treatment was associated with changes in biomarkers and bacterial counts in the course of the study. The effects of adjunctive antiseptic irrigation were limited in the applied protocol. View Full-Text
Keywords: inflammation; periodontitis; chlorhexidine; polyhexamethylene guanidine phosphate; irrigation inflammation; periodontitis; chlorhexidine; polyhexamethylene guanidine phosphate; irrigation
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MDPI and ACS Style

Vitt, A.; Babenka, A.; Boström, E.A.; Gustafsson, A.; Lira Junior, R.; Slizen, V.; Sorsa, T.; Tervahartiala, T.; Buhlin, K. Adjunctive Antiseptic Irrigation of Periodontal Pockets: Effects on Microbial and Cytokine Profiles. Dent. J. 2020, 8, 124. https://doi.org/10.3390/dj8040124

AMA Style

Vitt A, Babenka A, Boström EA, Gustafsson A, Lira Junior R, Slizen V, Sorsa T, Tervahartiala T, Buhlin K. Adjunctive Antiseptic Irrigation of Periodontal Pockets: Effects on Microbial and Cytokine Profiles. Dentistry Journal. 2020; 8(4):124. https://doi.org/10.3390/dj8040124

Chicago/Turabian Style

Vitt, Anton, Andrei Babenka, Elisabeth A. Boström, Anders Gustafsson, Ronaldo Lira Junior, Veronica Slizen, Timo Sorsa, Taina Tervahartiala, and Kåre Buhlin. 2020. "Adjunctive Antiseptic Irrigation of Periodontal Pockets: Effects on Microbial and Cytokine Profiles" Dentistry Journal 8, no. 4: 124. https://doi.org/10.3390/dj8040124

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