Salivary Chromium and Cobalt Concentrations in Patients with Dental Metallic Restorations—A Pilot Study
Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Roberts, H.W.; Berzins, D.W.; Moore, B.K.; Charlton, D.G. Metal-ceramic alloys in dentistry: A review. J. Prosthodont. 2009, 18, 188–194. [Google Scholar] [CrossRef] [PubMed]
- Arakelyan, M.; Spagnuolo, G.; Iaculli, F.; Dikopova, N.; Antoshin, A.; Timashev, P.; Turkina, A. Minimization of Adverse Effects Associated with Dental Alloys. Materials 2022, 15, 7476. [Google Scholar] [CrossRef] [PubMed]
- Gaur, S.; Agnihotri, R.; Albin, S. Bio-Tribocorrosion of Titanium Dental Implants and Its Toxicological Implications: A Scoping Review. Sci. World J. 2022, 2022, 4498613. [Google Scholar] [CrossRef]
- Chepelova, N.; Antoshin, A.; Voloshin, S.; Usanova, A.; Efremov, Y.; Makeeva, M.; Evlashin, S.; Stepanov, M.; Turkina, A.; Timashev, P. Oral Galvanism Side Effects: Comparing Alloy Ions and Galvanic Current Effects on the Mucosa-like Model. J. Funct. Biomater. 2023, 14, 564. [Google Scholar] [CrossRef]
- Mani, G.; Porter, D.; Collins, S.; Schatz, T.; Ornberg, A.; Shulfer, R. A review on manufacturing processes of cobalt-chromium alloy implants and its impact on corrosion resistance and biocompatibility. J. Biomed. Mater. Res. B Appl. Biomater. 2024, 112, e35431. [Google Scholar] [CrossRef]
- Zeng, L.; Xiang, N.; Wei, B. A comparison of corrosion resistance of cobalt-chromium-molybdenum metal ceramic alloy fabricated with selective laser melting and traditional processing. J. Prosthet. Dent. 2014, 112, 1217–1224. [Google Scholar] [CrossRef] [PubMed]
- Ique, M.M.A.; Ferreira, M.F.; Botazzo Delbem, A.C.; de Mendonça, M.R. Corrosion-induced changes in surface properties and roughness of orthodontic wires. Am. J. Orthod. Dentofac. Orthop. 2024, 165, 565–575. [Google Scholar] [CrossRef]
- Bechir, F.; Bataga, S.M.; Ungureanu, E.; Vranceanu, D.M.; Pacurar, M.; Bechir, E.S.; Cotrut, C.M. Experimental Study Regarding the Behavior at Different pH of Two Types of Co-Cr Alloys Used for Prosthetic Restorations. Materials 2021, 14, 4635. [Google Scholar] [CrossRef]
- Kameda, T.; Ohkuma, K.; Oda, H.; Sano, N.; Batbayar, N.; Terashima, Y.; Sato, S.; Terada, K. Magnetic fields from electric toothbrushes promote corrosion in orthodontic stainless steel appliances but not in titanium appliances. Dent. Mater. J. 2013, 32, 959–969. [Google Scholar] [CrossRef]
- Farrag, O.G.A.E.G.; Shamaa, N.E.-D.A.; Elgameay, W.E.; Bayoumi, D.A. Clinical effect of chlorhexidine and sodium fluoride on corrosion behavior and surface topography of nitinol orthodontic archwires. BMC Oral Health 2024, 24, 564. [Google Scholar] [CrossRef]
- Schedle, A.; Samorapoompichit, P.; Rausch-Fan, X.; Franz, A.; Füreder, W.; Sperr, W.; Ellinger, A.; Slavicek, R.; Boltz-Nitulescu, G.; Valent, P. Response of L-929 Fibroblasts, Human Gingival Fibroblasts, and Human Tissue Mast Cells to Various Metal Cations. J. Dent. Res. 1995, 74, 1513–1520. [Google Scholar] [CrossRef] [PubMed]
- Achmad, R.B.; Auerkari, E. Effects of Chromium on Human Body. Annu. Res. Rev. Biol. 2017, 17, 1–8. [Google Scholar] [CrossRef]
- Pavesi, T.; Moreira, J.C. Mechanisms and individuality in chromium toxicity in humans. J. Appl. Toxicol. 2020, 40, 1183–1197. [Google Scholar] [CrossRef] [PubMed]
- Dotaniya, M.L.; Saha, J.K.; Rajendiran, S.; Coumar, M.V.; Meena, V.D.; Kundu, S.; Patra, A.K. Chromium toxicity mediated by application of chloride and sulfate ions in Vertisol of Central India. Environ. Monit. Assess. 2019, 191, 429. [Google Scholar] [CrossRef]
- Sun, H.; Brocato, J.; Costa, M. Oral Chromium Exposure and Toxicity. Curr. Environ. Health Rep. 2015, 2, 295–303. [Google Scholar] [CrossRef] [PubMed]
- Genchi, G.; Lauria, G.; Catalano, A.; Carocci, A.; Sinicropi, M.S. Prevalence of Cobalt in the Environment and Its Role in Biological Processes. Biology 2023, 12, 1335. [Google Scholar] [CrossRef]
- Bauer, C.; Stotter, C.; Jeyakumar, V.; Niculescu-Morzsa, E.; Simlinger, B.; Rodríguez Ripoll, M.; Klestil, T.; Franek, F.; Nehrer, S. Concentration-Dependent Effects of Cobalt and Chromium Ions on Osteoarthritic Chondrocytes. Cartilage 2021, 13 (Suppl. S2), 908S–919S. [Google Scholar] [CrossRef]
- Messer, R.L.; Bishop, S.; Lucas, L.C. Effects of metallic ion toxicity on human gingival fibroblasts morphology. Biomaterials 1999, 20, 1647–1657. [Google Scholar] [CrossRef]
- Akbar, M.; Brewer, J.M.; Grant, M.H. Effect of chromium and cobalt ions on primary human lymphocytes in vitro. J. Immunotoxicol. 2011, 8, 140–149. [Google Scholar] [CrossRef]
- Lan, L.; Feng, Z.; Liu, X.; Zhang, B. The roles of essential trace elements in T cell biology. J. Cell. Mol. Med. 2024, 28, e18390. [Google Scholar] [CrossRef]
- Registration Dossier—ECHA. Available online: https://echa.europa.eu/bg/registration-dossier/-/registered-dossier/15506/7/1 (accessed on 30 October 2024).
- Zhong, Q.; Pan, X.; Chen, Y.; Lian, Q.; Gao, J.; Xu, Y.; Wang, J.; Shi, Z.; Cheng, H. Prosthetic Metals: Release, Metabolism and Toxicity. Int. J. Nanomed. 2024, 19, 5245–5267. [Google Scholar] [CrossRef] [PubMed]
- Tomova, Z.; Tomov, D.; Vlahova, A. The impact of dental metal restorations on the oral oxidative stress level. J. Clin. Exp. Dent. 2023, 15, e205–e209. [Google Scholar] [CrossRef] [PubMed]
- Pandey, M.; Reddy, V.; Wanjari, V. Comparative evaluation of citric acid and TENS as means for salivary stimulation in adults: An Invivo study. J. Indian Acad. Oral Med. Radiol. 2019, 31, 36–39. [Google Scholar]
- Kim, Y.J.; Kim, Y.K.; Kho, H.S. Effects of smoking on trace metal levels in saliva. Oral Dis. 2010, 16, 823–830. [Google Scholar] [CrossRef]
- Kassapidou, M.; Franke Stenport, V.; Hjalmarsson, L.; Johansson, C.B. Cobalt-chromium alloys in fixed prosthodontics in Sweden. Acta Biomater. Odontol. Scand. 2017, 3, 53–62. [Google Scholar] [CrossRef]
- Tuna, S.H.; Pekmez, N.Ö.; Keyf, F.; Canli, F. The influence of the pure metal components of four different casting alloys on the electrochemical properties of the alloys. Dent. Mater. 2009, 25, 1096–1103. [Google Scholar] [CrossRef]
- Bandyopadhyay, A.; Traxel, K.D.; Avila, J.D.; Mitra, I.; Bose, S. Biomaterials Science, 4th ed.; Academic Press: Cambridge, MA, USA, 2020; pp. 257–269. [Google Scholar]
- Yang, L.; Zhu, Q.; Xie, X.; Cao, X.; Wu, Y.; Chen, S.; Qu, J.-E. Electrochemical behavior of CoCrMo alloy for dental applications in acidic artificial saliva containing albumin. Colloids Surf. B Biointerfaces 2019, 184, 110492. [Google Scholar] [CrossRef]
- Lu, C.; Zheng, Y.; Zhong, Q. Corrosion of dental alloys in artificial saliva with Streptococcus mutans. PLoS ONE 2017, 12, e0174440. [Google Scholar] [CrossRef]
- Carek, A.; Slokar, B.L.; Bubalo, V. Metal Ions Release from Welded Co-Cr Dental Alloys. Materials 2023, 16, 3398. [Google Scholar] [CrossRef]
- Sfondrini, M.F.; Cacciafesta, V.; Maffia, E.; Massironi, S.; Scribante, A.; Alberti, G. Chromium release from new stainless steel, recycled and nickel-free orthodontic brackets. Angle Orthod. 2009, 79, 361–367. [Google Scholar] [CrossRef] [PubMed]
- Brown, M.N.; Phan, L.H.; Bryant, D.M.; Smith, R.A.; Morrow, B.R.; Mihalko, W.M. In Vitro Inflammatory Cell-Induced Corrosion Using a Lymphocyte and Macrophage Coculture. J. Arthroplast. 2024, 39, S280–S285. [Google Scholar] [CrossRef] [PubMed]
- Marti, A. Cobalt-base alloys used in surgery. Injury 2000, 31 (Suppl. S4), D18–D21. [Google Scholar] [CrossRef] [PubMed]
- Cheung, A.C.; Banerjee, S.; Cherian, J.J.; Wong, F.; Butany, J.; Gilbert, C.; Overgaard, C.; Syed, K.; Zywiel, M.G.; Jacobs, J.J.; et al. Systemic cobalt toxicity from total hip arthroplasties: Review of a rare condition Part 2. measurement, risk factors, and step-wise approach to treatment. Bone Jt. J. 2016, 98, 14–20. [Google Scholar]
- Vaicelyte, A.; Janssen, C.; Le Borgne, M.; Grosgogeat, B. Cobalt–Chromium Dental Alloys: Metal Exposures, Toxicological Risks, CMR Classification, and EU Regulatory Framework. Crystals 2020, 10, 1151. [Google Scholar] [CrossRef]
- Garhammer, P.; Hiller, K.-A.; Reitinger, T.; Schmalz, G. Metal content of saliva of patients with and without metal restorations. Clin. Oral Investig. 2004, 8, 238–242. [Google Scholar] [CrossRef] [PubMed]
- Yassaei, S.; Dadfarnia, S.; Ahadian, H.; Moradi, F. Nickel and chromium levels in the saliva of patients with fixed orthodontic appliances. Orthodontics 2013, 14, e76–e81. [Google Scholar] [CrossRef]
- Pan, Y.; Lin, Y.; Jiang, L.; Lin, H.; Xu, C.; Lin, D.; Cheng, H. Removal of dental alloys and titanium attenuates trace metals and biological effects on liver and kidney. Chemosphere 2020, 243, 125205. [Google Scholar] [CrossRef]
Saliva Sample | Presence of Metal Objects | Min | Max | Median | Mean | St. Dev. |
---|---|---|---|---|---|---|
NS | Yes | 0.02 | 2.83 | 0.28 | 0.44 | 0.86 |
NS | No | 0.00 | 3.45 | 0.15 | 0.66 | 0.81 |
SS | Yes | 0.06 | 1.18 | 0.27 | 0.37 | 0.28 |
SS | No | 0.01 | 4.71 | 0.27 | 0.55 | 1.1 |
Saliva Sample | Presence of Metal Objects | Min | Max | Median | Mean | St. Dev. |
---|---|---|---|---|---|---|
NS | Yes | 0.00 | 6.21 | 0.82 | 1.07 | 1.39 |
NS | No | 0.02 | 0.91 | 0.37 | 0.43 | 0.28 |
SS | Yes | 0.00 | 2.93 | 0.59 | 0.93 | 0.79 |
SS | No | 0.06 | 1.76 | 0.73 | 0.72 | 0.42 |
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Tomova, Z.; Tomov, D.; Davcheva, D.; Uzunova, Y. Salivary Chromium and Cobalt Concentrations in Patients with Dental Metallic Restorations—A Pilot Study. Dent. J. 2024, 12, 362. https://doi.org/10.3390/dj12110362
Tomova Z, Tomov D, Davcheva D, Uzunova Y. Salivary Chromium and Cobalt Concentrations in Patients with Dental Metallic Restorations—A Pilot Study. Dentistry Journal. 2024; 12(11):362. https://doi.org/10.3390/dj12110362
Chicago/Turabian StyleTomova, Zlatina, Desislav Tomov, Delyana Davcheva, and Yordanka Uzunova. 2024. "Salivary Chromium and Cobalt Concentrations in Patients with Dental Metallic Restorations—A Pilot Study" Dentistry Journal 12, no. 11: 362. https://doi.org/10.3390/dj12110362
APA StyleTomova, Z., Tomov, D., Davcheva, D., & Uzunova, Y. (2024). Salivary Chromium and Cobalt Concentrations in Patients with Dental Metallic Restorations—A Pilot Study. Dentistry Journal, 12(11), 362. https://doi.org/10.3390/dj12110362