Tooth Agenesis Patterns in Orofacial Clefting Using Tooth Agenesis Code: A Meta-Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Search Strategy
2.2. Eligibility and Exclusion Criteria
2.3. Study Selection
2.4. Data Collection
2.5. Meta-Analysis
3. Results
3.1. Study Selection
3.2. Study Characteristics
3.3. TAC Patterns
3.4. Sex
3.5. Cleft Type
3.6. Laterality
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Maxillary Right (Q1) | Maxillary Left (Q2) | |||||||||||||
Maxillary | 17 | 16 | 15 | 14 | 13 | 12 | 11 | 21 | 22 | 23 | 24 | 25 | 26 | 27 |
AV | 64 | 32 | 16 | 8 | 4 | 2 | 1 | 1 | 2 | 4 | 8 | 16 | 32 | 64 |
Mandibular | 47 | 46 | 45 | 44 | 43 | 42 | 41 | 31 | 32 | 33 | 34 | 35 | 36 | 37 |
Mandibular Right (Q4) | Mandibular Left (Q3) |
Study Title | Authors | Publication Date | Control Group | Outcome Assessed | Sample Size | Sample | Sex Provided |
---|---|---|---|---|---|---|---|
Tooth agenesis patterns in bilateral cleft lip and palate [18] | Theodosia N. Bartzela, Carine E.L. Carels, Ewald M. Bronkhorst, Elisabeth Rønning, Sara Rizell, Anne Marie Kuijpers-Jagtman | 2010 | No | TAC patterns | 240 | CL/P | No |
Patterns of tooth agenesis in patients with orofacial clefts [14] | Ruurd R. Hermus, Arjen J. van Wijk, Stephan P. K. Tan, Gem J. C. Kramer, Edwin M. Ongkosuwito | 2013 | No | TAC patterns | 910 | CL/P | Yes |
Tooth agenesis code (TAC) in complete unilateral and bilateral cleft lip and palate patients [15] | Ana López-Giménez, Javier Silvestre-Rangil, Francisco Javier Silvestre, Vanessa Paredes-Gallardo | 2017 | No | TAC patterns | 118 | CL/P | No |
Non-syndromic tooth agenesis patterns and their association with other dental anomalies: A retrospective study [16] | Bianca Núbia Souza-Silva, Walbert de Andrade Vieira, Ítalo de Macedo Bernardino, Marília Jesus Batistad, Marcos Alan Vieira Bittencourt, Luiz Renato Paranhos | 2018 | No | TAC patterns | 2239 | Non-CL/P | No |
OFC1 Data | Unpublished | Yes | TAC patterns | 1056 | CL/P and Non-CL/P | Yes |
Combined Data Proportion (95% CI) | I2: Combined | Case Data Proportion (95% CI) | I2: Cases | Control Data Proportion (95% CI) | I2: Controls | |
---|---|---|---|---|---|---|
0.0.0.0 | 0.77 (0.51, 0.915) | 99.36% | 0.516 (0.432, 0.599) | 90.4% | 0.971 (0.964, 0.976) | 0% |
0.2.0.0 | 0.038 (0.017, 0.081) | 95.06% | 0.097 (0.07, 0.135) | 76.37% | 0.003 (0.001, 0.009) | 52.85% |
2.0.0.0 | 0.031 (0.014, 0.065) | 93.43% | 0.071 (0.058, 0.086) | 19.07% | 0.003 (0.001, 0.009) | 52.85% |
2.2.0.0 | 0.029 (0.011, 0.074) | 95.12% | 0.066 (0.035, 0.119) | 89.54% | 0.003 (0.002, 0.006) | 0% |
0.16.0.0 | 0.005 (0.002, 0.015) | 71.07% | 0.012 (0.005, 0.025) | 44.28% | 0.001 (0, 0.006) | 31.51% |
0.0.16.16 | 0.003 (0.001, 0.011) | 66.22% | 0.009 (0.004, 0.018) | 15.08% | 0.001 (0, 0.004) | 0% |
0.0.0.16 | 0.005 (0.002, 0.009) | 37.02% | 0.007 (0.004, 0.013) | 0% | 0.002 (0.001, 0.005) | 0% |
16.16.0.0 | 0.004 (0.001, 0.012) | 71.33% | 0.008 (0.003, 0.021) | 51.68% | 0.001 (0, 0.003) | 0% |
16.16.16.16 | 0.003 (0.001, 0.007) | 46.54% | 0.006 (0.003, 0.012) | 0% | 0.001 (0, 0.004) | 0% |
0.0.16.0 | 0.004 (0.002, 0.01) | 59.28% | 0.008 (0.004, 0.015) | 14.71% | 0.001 (0, 0.003) | 0% |
16.0.0.0 | 0.005 (0.002, 0.012) | 54.64% | 0.008 (0.005, 0.014) | 0% | 0.001 (0, 0.006) | 31.51% |
0.18.0.0 | 0.003 (0.001, 0.009) | 50.54% | 0.006 (0.002, 0.013) | 18.98% | 0 (0, 0.003) | 0% |
16.2.0.0 | 0.003 (0.001, 0.008) | 51.36% | 0.005 (0.002, 0.013) | 30.72% | 0 (0, 0.003) | 0% |
2.16.0.0 | 0.003 (0.001, 0.011) | 68.77% | 0.005 (0.001, 0.02) | 66.83% | 0 (0, 0.003) | 0% |
0.0.2.0 | 0.002 (0.001, 0.005) | 0% | 0.004 (0.002, 0.009) | 0% | 0.001 (0, 0.004) | 0% |
0.1.0.0 | 0.003 (0.001, 0.006) | 15.53% | 0.004 (0.002, 0.009) | 0% | 0.001 (0, 0.003) | 0% |
0.2.16.0 | 0.002 (0.001, 0.008) | 54.41% | 0.004 (0.001, 0.015) | 50.02% | 0 (0, 0.003) | 0% |
16.18.16.16 | 0.002 (0.001, 0.006) | 23.5% | 0.004 (0.002, 0.009) | 0% | 0 (0, 0.003) | 0% |
18.0.0.0 | 0.002 (0, 0.01) | 71.05% | 0.004 (0.001, 0.022) | 71.06% | 0 (0, 0.003) | 0% |
18.18.0.0 | 0.005 (0.001, 0.015) | 72.51% | 0.009 (0.003, 0.024) | 65.58% | 0 (0, 0.003) | 0% |
2.18.0.0 | 0.003 (0.001, 0.008) | 51.66% | 0.004 (0.002, 0.013) | 36.91% | 0 (0, 0.003) | 0% |
2.2.16.16 | 0.002 (0.001, 0.006) | 24.42% | 0.004 (0.002, 0.009) | 0% | 0.001 (0, 0.003) | 0% |
0.0.0.2 | 0.001 (0.001, 0.003) | 0% | 0.002 (0, 0.006) | 0% | 0.001 (0, 0.003) | 0% |
0.2.16.16 | 0.001 (0.001, 0.004) | 0% | 0.002 (0.001, 0.007) | 0% | 0 (0, 0.003) | 0% |
0.4.0.0 | 0.002 (0.001, 0.004) | 0% | 0.003 (0.001, 0.007) | 0% | 0.001 (0, 0.003) | 0% |
0.8.0.0 | 0.001 (0.001, 0.003) | 0% | 0.002 (0.001, 0.007) | 0% | 0.001 (0, 0.003) | 0% |
1.0.0.0 | 0.003 (0.001, 0.007) | 43.62% | 0.005 (0.002, 0.011) | 0% | 0.001 (0, 0.003) | 0% |
16.18.0.0 | 0.002 (0.001, 0.005) | 15.81% | 0.003 (0.001, 0.008) | 0% | 0 (0, 0.003) | 0% |
18.18.16.16 | 0.003 (0.001, 0.01) | 67.84% | 0.005 (0.001, 0.019) | 62.8% | 0 (0, 0.003) | 0% |
0.0.32.32 | 0.001 (0, 0.003) | 0% | 0.001 (0, 0.006) | 0% | 0.001 (0, 0.004) | 0% |
1.1.0.0 | 0.001 (0.001, 0.004) | 4.2% | 0.002 (0.001, 0.008) | 2.78% | 0.001 (0, 0.003) | 0% |
Control Percent with Pattern | Case Percent with Pattern | Odds Ratio (95% CI) | p-Value | |
---|---|---|---|---|
0.0.0.0 | 97.47% | 61.63% | 23.91 (13.6, 45.38) | <2 × 10−16 |
0.2.0.0 | 0.54% | 11.13% | 0.04 (0.01, 0.14) | 1.3 × 10−15 |
2.0.0.0 | 0.54% | 8.35% | 0.06 (0.01, 0.19) | 3.3 × 10−11 |
2.2.0.0 | 0% | 8.35% | 0 (0, 0.08) | 1.2 × 10−14 |
0.16.0.0 | 0.18% | 0.2% | 0.91 (0.01, 71.49) | >0.99 |
0.0.16.16 | 0.18% | 0% | Inf (0.02, Inf) | >0.99 |
0.0.0.16 | 0% | 0.4% | 0 (0, 4.84) | 0.23 |
16.16.0.0 | 0% | 0.2% | 0 (0, 35.47) | 0.48 |
16.16.16.16 | 0.18% | 0% | Inf (0.02, Inf) | >0.99 |
0.0.16.0 | 0.18% | 0% | Inf (0.02, Inf) | >0.99 |
16.0.0.0 | 0.18% | 0.6% | 0.3 (0.01, 3.78) | 0.35 |
0.18.0.0 | 0% | 0% | 0 (0, Inf) | >0.99 |
16.2.0.0 | 0% | 0% | 0 (0, Inf) | >0.99 |
2.16.0.0 | 0% | 0.2% | 0 (0, 35.47) | 0.48 |
0.0.2.0 | 0% | 0.2% | 0 (0, 35.47) | 0.48 |
0.1.0.0 | 0.18% | 0.6% | 0.3 (0.01, 3.78) | 0.35 |
0.2.16.0 | 0% | 0% | 0 (0, Inf) | >0.99 |
16.18.16.16 | 0% | 0.2% | 0 (0, 35.47) | 0.48 |
18.0.0.0 | 0% | 0% | 0 (0, Inf) | >0.99 |
18.18.0.0 | 0% | 0.6% | 0 (0, 2.2) | 0.11 |
2.18.0.0 | 0% | 0.2% | 0 (0, 35.47) | 0.48 |
2.2.16.16 | 0% | 0.2% | 0 (0, 35.47) | 0.48 |
0.0.0.2 | 0.18% | 0% | Inf (0.02, Inf) | >0.99 |
0.2.16.16 | 0% | 0% | 0 (0, Inf) | >0.99 |
0.4.0.0 | 0% | 0.4% | 0 (0, 4.84) | 0.23 |
0.8.0.0 | 0% | 0% | 0 (0, Inf) | >0.99 |
1.0.0.0 | 0% | 0.6% | 0 (0, 2.2) | 0.11 |
16.18.0.0 | 0% | 0% | 0 (0, Inf) | >0.99 |
18.18.16.16 | 0% | 0.2% | 0 (0, 35.47) | 0.48 |
0.0.32.32 | 0.18% | 0% | Inf (0.02, Inf) | >0.99 |
1.1.0.0 | 0% | 0% | 0 (0, Inf) | >0.99 |
CL | I2 | CLP | I2 | CP | I2 | CL vs. CLP OR | CL vs. CP OR | CLP vs. CP OR | |
---|---|---|---|---|---|---|---|---|---|
0.0.0.0 | 0.693 (0.642, 0.74) | 0% | 0.45 (0.412, 0.488) | 33.54% | 0.879 (0.281, 0.993) | 93.98% | 2.829 (2.151, 3.722) p = 6.4 × 10−14 | Failed BD Test | Failed BD Test |
0.2.0.0 | 0.067 (0.037, 0.119) | 27.35% | 0.102 (0.064, 0.16) | 83.6% | 0.014 (0.005, 0.039) | 0% | 0.489 (0.303, 0.788) p = 0.0041 | 6.194 (1.84, 20.847) p = 0.0017 | 13.134 (4.07, 42.384) p = 9.3 × 10−8 |
0.0.16.16 | 0.012 (0.004, 0.034) | 0% | 0.006 (0.003, 0.014) | 0% | 0.028 (0.006, 0.116) | 37.12% | Failed BD Test | Failed BD Test | Failed BD Test |
0.1.0.0 | 0.025 (0.011, 0.059) | 7.37% | 0.004 (0.002, 0.011) | 0% | 0.004 (0.001, 0.029) | 0% | 8.528 (1.129, 64.421) p = 0.026 | Failed BD Test | Failed BD Test |
0.16.0.0 | 0.013 (0.005, 0.034) | 0% | 0.02 (0.012, 0.031) | 0% | 0.006 (0.001, 0.028) | 0% | 0.337 (0.074, 1.545) p = 0.24 | Failed BD Test | 4.477 (0.57, 35.156) p = 0.22 |
16.2.0.0 | 0.012 (0.004, 0.034) | 0% | 0.008 (0.004, 0.016) | 0% | 0.004 (0.001, 0.029) | 0% | Failed BD Test | Failed BD Test | Failed BD Test |
2.0.0.0 | 0.067 (0.029, 0.146) | 61.14% | 0.093 (0.059, 0.144) | 80.34% | 0.014 (0.005, 0.039) | 0% | Failed BD Test | 4.48 (1.321, 15.194) p = 0.016 | 9.221 (2.832, 30.029) p = 2.1 × 10−5 |
2.2.0.0 | 0.037 (0.011, 0.111) | 61.61% | 0.081 (0.05, 0.127) | 72.74% | 0.019 (0.008, 0.045) | 0% | 0.407 (0.189, 0.879) p = 0.029 | 1.239 (0.402, 3.823) p = 0.93 | 3.147 (1.227, 8.072) p = 0.02 |
0.0.0.16 | 0.021 (0.009, 0.049) | 0% | 0.006 (0.003, 0.014) | 0% | 0.023 (0.01, 0.052) | 0% | 13.304 (1.174, 150.774) p = 0.045 | 0.604 (0.161, 2.264) p = 0.68 | Failed BD Test |
0.16.16.16 | 0.013 (0.005, 0.036) | 0% | 0.006 (0.003, 0.013) | 0% | 0.004 (0.001, 0.029) | 0% | Failed BD Test | Failed BD Test | Failed BD Test |
16.0.0.0 | 0.012 (0.004, 0.036) | 0% | 0.012 (0.007, 0.022) | 0% | 0.01 (0.003, 0.033) | 0% | Failed BD Test | Failed BD Test | 1.206 (0.24, 6.07) p = 0.82 |
16.16.0.0 | 0.012 (0.004, 0.036) | 0% | 0.014 (0.008, 0.024) | 0% | 0.01 (0.003, 0.033) | 0% | Failed BD Test | Failed BD Test | 1.164 (0.23, 5.903) p = 0.86 |
16.18.16.16 | 0.012 (0.004, 0.036) | 0% | 0.007 (0.003, 0.015) | 0% | 0.004 (0.001, 0.029) | 0% | Failed BD Test | Failed BD Test | Failed BD Test |
0.0.16.0 | 0.012 (0.004, 0.036) | 0% | 0.006 (0.002, 0.013) | 0% | 0.023 (0.01, 0.052) | 0% | Failed BD Test | Failed BD Test | Failed BD Test |
0.18.0.0 | 0.012 (0.004, 0.036) | 0% | 0.011 (0.006, 0.02) | 0% | 0.004 (0.001, 0.029) | 0% | Failed BD Test | Failed BD Test | Failed BD Test |
16.16.16.16 | 0.012 (0.004, 0.036) | 0% | 0.006 (0.002, 0.013) | 0% | 0.014 (0.005, 0.039) | 0% | Failed BD Test | Failed BD Test | Failed BD Test |
2.2.16.16 | 0.012 (0.004, 0.036) | 0% | 0.007 (0.003, 0.014) | 0% | 0.004 (0.001, 0.029) | 0% | Failed BD Test | Failed BD Test | Failed BD Test |
2.16.0.0 | 0.012 (0.004, 0.036) | 0% | 0.008 (0.004, 0.018) | 0% | 0.004 (0.001, 0.029) | 0% | Failed BD Test | Failed BD Test | Failed BD Test |
1.0.0.0 | 0.012 (0.004, 0.036) | 0% | 0.009 (0.005, 0.019) | 0% | 0.004 (0.001, 0.029) | 0% | Failed BD Test | Failed BD Test | Failed BD Test |
3.0.0.0 | 0.012 (0.004, 0.036) | 0% | 0.006 (0.002, 0.014) | 0% | 0.004 (0.001, 0.029) | 0% | Failed BD Test | Failed BD Test | Failed BD Test |
18.18.0.0 | 0.012 (0.004, 0.036) | 0% | 0.014 (0.008, 0.024) | 0% | 0.004 (0.001, 0.029) | 0% | Failed BD Test | Failed BD Test | Failed BD Test |
2.18.0.0 | 0.012 (0.004, 0.036) | 0% | 0.009 (0.005, 0.018) | 0% | 0.004 (0.001, 0.029) | 0% | Failed BD Test | Failed BD Test | Failed BD Test |
18.18.16.16 | 0.012 (0.004, 0.036) | 0% | 0.01 (0.005, 0.02) | 0% | 0.004 (0.001, 0.029) | 0% | Failed BD Test | Failed BD Test | Failed BD Test |
0.0.2.0 | 0.012 (0.004, 0.036) | 0% | 0.006 (0.003, 0.013) | 0% | 0.01 (0.003, 0.033) | 0% | Failed BD Test | Failed BD Test | 0.125 (0.009, 1.821) p = 0.32 |
18.2.0.0 | 0.012 (0.004, 0.036) | 0% | 0.009 (0.004, 0.019) | 0% | 0.004 (0.001, 0.029) | 0% | Failed BD Test | Failed BD Test | Failed BD Test |
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Howe, B.J.; Pendleton, C.; Withanage, M.H.H.; Childs, C.A.; Zeng, E.; van Wijk, A.; Hermus, R.; Padilla, C.; Hecht, J.T.; Poletta, F.A.; et al. Tooth Agenesis Patterns in Orofacial Clefting Using Tooth Agenesis Code: A Meta-Analysis. Dent. J. 2022, 10, 128. https://doi.org/10.3390/dj10070128
Howe BJ, Pendleton C, Withanage MHH, Childs CA, Zeng E, van Wijk A, Hermus R, Padilla C, Hecht JT, Poletta FA, et al. Tooth Agenesis Patterns in Orofacial Clefting Using Tooth Agenesis Code: A Meta-Analysis. Dentistry Journal. 2022; 10(7):128. https://doi.org/10.3390/dj10070128
Chicago/Turabian StyleHowe, Brian J., Chandler Pendleton, Miyuraj Harishchandra Hikkaduwa Withanage, Christopher A. Childs, Erliang Zeng, Arjen van Wijk, Ruurd Hermus, Carmencita Padilla, Jacqueline T. Hecht, Fernando A. Poletta, and et al. 2022. "Tooth Agenesis Patterns in Orofacial Clefting Using Tooth Agenesis Code: A Meta-Analysis" Dentistry Journal 10, no. 7: 128. https://doi.org/10.3390/dj10070128
APA StyleHowe, B. J., Pendleton, C., Withanage, M. H. H., Childs, C. A., Zeng, E., van Wijk, A., Hermus, R., Padilla, C., Hecht, J. T., Poletta, F. A., Orioli, I. M., Buxó-Martínez, C. J., Deleyiannis, F., Vieira, A. R., Butali, A., Valencia-Ramirez, C., Restrepo Muñeton, C., Wehby, G. L., Weinberg, S. M., ... Xie, X. -J. (2022). Tooth Agenesis Patterns in Orofacial Clefting Using Tooth Agenesis Code: A Meta-Analysis. Dentistry Journal, 10(7), 128. https://doi.org/10.3390/dj10070128