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Article

Salivary Scca1, Scca2 and Trop2 in Oral Cancer Patients—A Cross-Sectional Pilot Study

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Department of Medical Chemistry, Biochemistry and Clinical Chemistry, University of Zagreb School of Medicine, 10000 Zagreb, Croatia
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Department of Oral Surgery, University of Zagreb School of Dental Medicine, Av. Gojka Šuška 6, 10000 Zagreb, Croatia
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Department of Maxillofacial and Oral Surgery, University Hospital Dubrava, 10000 Zagreb, Croatia
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Department of Medical Informatics, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia
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Department of Physical Chemistry, Ruđer Bošković Institute, 10000 Zagreb, Croatia
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Department of Oral Medicine, University of Zagreb School of Dental Medicine, 10000 Zagreb, Croatia
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Department of Endodontics and Restorative Dentistry, University of Zagreb School of Dental Medicine, 10000 Zagreb, Croatia
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Takashi Muramatsu and Ricardo D. Coletta
Dent. J. 2022, 10(4), 70; https://doi.org/10.3390/dj10040070
Received: 15 February 2022 / Revised: 4 April 2022 / Accepted: 14 April 2022 / Published: 15 April 2022
(This article belongs to the Special Issue Molecular Diagnostics in Oral Diseases)
Oral squamous cell carcinoma (OSCC) is frequently diagnosed in the advanced stages. The purpose of this paper is to determine the salivary values of SCCA1, SCCA2 and TROP2 in patients with T1N0M0 OSCC and to compare them with the values obtained from healthy individuals. Unstimulated (UWS) and stimulated (SWS) saliva was sampled from 29 patients with T1N0M0 OSCC and 29 sex- and age-matched healthy individuals. Statistical difference was observed in SCCA1 and SCCA2 levels both in UWS and SWS samples. TROP2 was not measurable in most of the salivary samples. Both SCCA1 and SCCA2 could represent potential biomarkers for the early-stage OSCC. Research on a larger sample and biomarker validation is needed to assess the clinical potential of SCCA1 and SCCA2 in the OSCC early diagnostics. View Full-Text
Keywords: oral cancer; early diagnosis; biomarkers; saliva oral cancer; early diagnosis; biomarkers; saliva
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MDPI and ACS Style

Karmelić, I.; Salarić, I.; Baždarić, K.; Rožman, M.; Zajc, I.; Mravak-Stipetić, M.; Bago, I.; Brajdić, D.; Lovrić, J.; Macan, D. Salivary Scca1, Scca2 and Trop2 in Oral Cancer Patients—A Cross-Sectional Pilot Study. Dent. J. 2022, 10, 70. https://doi.org/10.3390/dj10040070

AMA Style

Karmelić I, Salarić I, Baždarić K, Rožman M, Zajc I, Mravak-Stipetić M, Bago I, Brajdić D, Lovrić J, Macan D. Salivary Scca1, Scca2 and Trop2 in Oral Cancer Patients—A Cross-Sectional Pilot Study. Dentistry Journal. 2022; 10(4):70. https://doi.org/10.3390/dj10040070

Chicago/Turabian Style

Karmelić, Ivana, Ivan Salarić, Ksenija Baždarić, Marko Rožman, Ivan Zajc, Marinka Mravak-Stipetić, Ivona Bago, Davor Brajdić, Jasna Lovrić, and Darko Macan. 2022. "Salivary Scca1, Scca2 and Trop2 in Oral Cancer Patients—A Cross-Sectional Pilot Study" Dentistry Journal 10, no. 4: 70. https://doi.org/10.3390/dj10040070

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