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Open AccessReview

Iron Oxide Nanoparticles: An Alternative for Positive Contrast in Magnetic Resonance Imaging

NanoMedMol Group, Instituto de Química Medica (IQM), Consejo Superior de Investigaciones Científicas (CSIC), 28006 Madrid, Spain
Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain
Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), 28029 Madrid, Spain
Ciber de Enfermedades Respiratorias (CIBERES), 28029 Madrid, Spain
Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), 20014 Donostia San Sebastián, Spain
IKERBASQUE, Basque Foundation for Science, 48013 Bilbao, Spain
School of Biomedical Engineering & Imaging Sciences, King’s College London, St. Thomas’ Hospital, London SE1 7EH, UK
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Inorganics 2020, 8(4), 28;
Received: 31 March 2020 / Revised: 7 April 2020 / Accepted: 8 April 2020 / Published: 10 April 2020
Iron oxide nanoparticles have been extensively utilised as negative (T2) contrast agents in magnetic resonance imaging. In the past few years, researchers have also exploited their application as positive (T1) contrast agents to overcome the limitation of traditional Gd3+ contrast agents. To provide T1 contrast, these particles must present certain physicochemical properties with control over the size, morphology and surface of the particles. In this review, we summarise the reported T1 iron oxide nanoparticles and critically revise their properties, synthetic protocols and application, not only in MRI but also in multimodal imaging. In addition, we briefly summarise the most important nanoparticulate Gd and Mn agents to evaluate whether T1 iron oxide nanoparticles can reach Gd/Mn contrast capabilities. View Full-Text
Keywords: iron oxide nanoparticles; magnetic resonance imaging; positive contrast agents iron oxide nanoparticles; magnetic resonance imaging; positive contrast agents
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MDPI and ACS Style

Fernández-Barahona, I.; Muñoz-Hernando, M.; Ruiz-Cabello, J.; Herranz, F.; Pellico, J. Iron Oxide Nanoparticles: An Alternative for Positive Contrast in Magnetic Resonance Imaging. Inorganics 2020, 8, 28.

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