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Cytotoxic Gold(I) Complexes with Amidophosphine Ligands Containing Thiophene Moieties

Departamento de Química Inorgánica, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH), CSIC-Universidad de Zaragoza, 50009 Zaragoza, Spain
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Inorganics 2019, 7(2), 13; https://doi.org/10.3390/inorganics7020013
Received: 14 December 2018 / Revised: 22 January 2019 / Accepted: 24 January 2019 / Published: 29 January 2019
A new phosphine ligand bearing a thiophene moiety, C4H3SNHCOCH2CH2PPh2 (L), has been prepared by reaction of the aminophosphine Ph2PCH2CH2NH2 with thiophenecarbonylchloride in the presence of triethylamine. The coordination behavior towards gold(I), gold(III) and silver(I) species has been studied and several metal compounds of different stoichiometry have been achieved, such as [AuL2]OTf, [AuXL] (X = Cl, C6F5), [Au(C6F5)3L], [AgL2]OTf or [Ag(OTf)L]. Additionally, the reactivity of the chloride gold(I) species with biologically relevant thiolates was explored, thus obtaining the neutral thiolate compounds [AuL(SR)] (SR = 2-thiocitosine, 2-thiolpyridine, 2-thiouracil, 2-thionicotinic acid, 2,3,4,6-tetra-6-acetyl-1-thiol-β-d-glucopyranosato or thiopurine). The antitumor activity of the compounds was measured by the MTT method in several cancer cells and the complexes exhibit excellent cytotoxic activity. View Full-Text
Keywords: gold; silver; amidophosphine; thiophene; cytotoxicity; cancer gold; silver; amidophosphine; thiophene; cytotoxicity; cancer
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MDPI and ACS Style

Goitia, H.; Villacampa, M.D.; Laguna, A.; Gimeno, M.C. Cytotoxic Gold(I) Complexes with Amidophosphine Ligands Containing Thiophene Moieties. Inorganics 2019, 7, 13.

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