Cytotoxic Gold(I) Complexes with Amidophosphine Ligands Containing Thiophene Moieties
Abstract
:1. Introduction
2. Results and Discussion
2.1. Synthesis and Characterization
2.2. X-ray Diffraction Studies
2.3. Biological Studies
3. Experimental Section
3.1. Instrumentation
3.2. Starting Materials
3.3. General Procedure for the Synthesis of Ligand L and Complexes 1–6
3.4. General Procedure for the Synthesis of Phosphinegold(I) Thionucleobase Analogues 7–12
3.5. Cristallography
3.6. Cell Culture
3.7. Cytotoxicity MTT Assay
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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IC50 (μM) | ||||
---|---|---|---|---|
Complex | A-549 | Hep-G2 | NIH-3T3 | PC-12 |
L | >100 | >100 | >100 | >100 |
1 | 48.9 ± 2.1 | 17.1 ± 1.1 | 1.4 ± 0.09 | 0.5 ± 0.1 |
2 | >100 | 16.9 ± 1.2 | 2.8 ± 0.9 | 1.6 ± 0.8 |
3 | 10.6 ± 1.4 | 56 ± 3.5 | 39.37 ± 2.2 | 1.6 ± 0.7 |
4 | >100 | >100 | >100 | >100 |
5 | 20.8 ± 2.1 | 10.0 ± 1.1 | 4.0 ± 0.8 | 1.1 ± 0.6 |
6 | 12.5 ± 1.2 | 78.9 ± 2.4 | 20.8 ± 1.8 | 6.9 ± 1.0 |
7 | 45.1 ± 2.7 | 5.9 ± 1.7 | 3.0 ± 1.2 | 1.0 ± 0.5 |
8 | 24.5 ± 1.8 | 6.7 ± 2.3 | 2.1 ± 0.4 | 0.5 ± 0.2 |
9 | >100 | 14.1 ± 2.5 | 6.1 ± 1.9 | 1.3 ± 0.4 |
10 | >100 | 15.8 ± 2.4 | 6.3 ± 1.7 | 2.7 ± 1.0 |
11 | 9.9 ± 1.4 | 5.9 ± 1.1 | 2.9 ± 0.9 | - |
12 | 65.7 ± 3.4 | >100 | 13.7 ± 2.4 | - |
Cisplatin | 64 | 25 ± 3.1 | 145 ± 13 | - |
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Goitia, H.; Villacampa, M.D.; Laguna, A.; Gimeno, M.C. Cytotoxic Gold(I) Complexes with Amidophosphine Ligands Containing Thiophene Moieties. Inorganics 2019, 7, 13. https://doi.org/10.3390/inorganics7020013
Goitia H, Villacampa MD, Laguna A, Gimeno MC. Cytotoxic Gold(I) Complexes with Amidophosphine Ligands Containing Thiophene Moieties. Inorganics. 2019; 7(2):13. https://doi.org/10.3390/inorganics7020013
Chicago/Turabian StyleGoitia, Helen, M. Dolores Villacampa, Antonio Laguna, and M. Concepción Gimeno. 2019. "Cytotoxic Gold(I) Complexes with Amidophosphine Ligands Containing Thiophene Moieties" Inorganics 7, no. 2: 13. https://doi.org/10.3390/inorganics7020013
APA StyleGoitia, H., Villacampa, M. D., Laguna, A., & Gimeno, M. C. (2019). Cytotoxic Gold(I) Complexes with Amidophosphine Ligands Containing Thiophene Moieties. Inorganics, 7(2), 13. https://doi.org/10.3390/inorganics7020013