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Inorganics 2016, 4(4), 34;

Metal-Free Reduction of Phosphine Oxides Using Polymethylhydrosiloxane

Department of Chemistry and Pharmaceutical Sciences, Vrije Universiteit Amsterdam (VU), De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands
Consiglio Nazionale delle Ricerche, Istituto di Chimica dei Composti Organometallici (CNR-ICCOM), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Italy
Van ’t Hoff Institute for Molecular Sciences, University of Amsterdam (UvA), Science Park 904, 1098 XH Amsterdam, the Netherlands
Authors to whom correspondence should be addressed.
Academic Editors: Lee J. Higham and Duncan H. Gregory
Received: 9 September 2016 / Revised: 31 October 2016 / Accepted: 1 November 2016 / Published: 3 November 2016
(This article belongs to the Special Issue Organophosphorus Chemistry 2016)
Full-Text   |   PDF [981 KB, uploaded 3 November 2016]   |  


A simple protocol is presented here for the use of inexpensive polymethylhydrosiloxane (PMHS), a waste product of the silicon industry, as stoichiometric reducing agent for phosphine oxides to phosphines, a highly desirable reaction to recover P-based ligands from their spent form. The reactions were studied by screening parameters, such as substrate to reductant ratio, temperature and reaction time, achieving good conversions and selectivities. View Full-Text
Keywords: phosphine oxides; reduction; PMHS; sustainable chemistry phosphine oxides; reduction; PMHS; sustainable chemistry

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Nicolas, E.; Guerriero, A.; Lyaskovskyy, V.; Peruzzini, M.; Lammertsma, K.; Gonsalvi, L.; Slootweg, J.C. Metal-Free Reduction of Phosphine Oxides Using Polymethylhydrosiloxane. Inorganics 2016, 4, 34.

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