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Open AccessFeature PaperArticle

3D Mueller-Matrix Diffusive Tomography of Polycrystalline Blood Films for Cancer Diagnosis

Optics and Publishing Department, Chernivtsi National University, 2 Kotsiubynskyi Str., 58012 Chernivtsi, Ukraine
Opto-Electronic and Measurement Techniques, University of Oulu, P. O. Box 4500, 90014 Oulu, Finland
Department of Forensic Medicine, Bukovinian State Medical University, 3 Theatral Sq., 58000 Chernivtsi, Ukraine
Interdisciplinary Laboratory of Biophotonics, National Research Tomsk State University, 634050 Tomsk, Russia
Institute of Engineering Physics for Biomedicine (PhysBio), National Research Nuclear University “MEPhI”, 15409 Moscow, Russia
Author to whom correspondence should be addressed.
Photonics 2018, 5(4), 54;
Received: 15 October 2018 / Revised: 19 November 2018 / Accepted: 23 November 2018 / Published: 1 December 2018
(This article belongs to the Special Issue Biomedical Photonics Advances)
The decomposition of the Mueller matrix of blood films has been carried out using differential matrices with polarized and depolarized parts. The use of a coherent reference wave is applied and the algorithm of digital holographic reconstruction of the field of complex amplitudes is used. On this basis, the 3D Mueller-matrix diffuse tomography method—the reconstruction of distributions of fluctuations of linear and circular birefringence of depolarizing polycrystalline films of human blood is analytically justified and experimentally tested. The dynamics of the change in the magnitude of the statistical moments of the first-fourth order, which characterize layer-by-layer distributions of fluctuations in the phase anisotropy of the blood film, is examined and analyzed. The most sensitive parameters for prostate cancer are the statistical moments of the third and fourth orders, which characterize the asymmetry and kurtosis of fluctuations in the linear and circular birefringence of blood films. The excellent accuracy of differentiation obtained polycrystalline films of blood from healthy donors and patients with cancer patients was achieved. View Full-Text
Keywords: Mueller-matrix; polarization; polarimetry; blood; cancer diagnostics Mueller-matrix; polarization; polarimetry; blood; cancer diagnostics
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Ushenko, V.; Sdobnov, A.; Syvokorovskaya, A.; Dubolazov, A.; Vanchulyak, O.; Ushenko, A.; Ushenko, Y.; Gorsky, M.; Sidor, M.; Bykov, A.; Meglinski, I. 3D Mueller-Matrix Diffusive Tomography of Polycrystalline Blood Films for Cancer Diagnosis. Photonics 2018, 5, 54.

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