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Open AccessArticle

FMTPen: A Miniaturized Handheld Fluorescence Molecular Tomography Probe for Image-Guided Cancer Surgery

1
Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA
2
Department of Surgery, Emory University, Atlanta, GA 30322, USA
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Author to whom correspondence should be addressed.
Photonics 2015, 2(1), 279-287; https://doi.org/10.3390/photonics2010279
Received: 19 February 2015 / Revised: 6 March 2015 / Accepted: 10 March 2015 / Published: 12 March 2015
We described a novel handheld device (termed FMTPen) for three-dimensional (3D) fluorescence molecular tomography (FMT). The FMTpen is characterized by its bendable structure and miniaturized size (10 mm in diameter) that can be potentially used as an intraoperative tool for the detection of tumor margins and for image-guided surgery. Several phantom experiments based on indocyanine green (ICG), an FDA approved near-infrared (NIR) fluorescent dye, were conducted to evaluate the imaging ability of this device. Two tumor-bearing mice were systematically injected with tumor-targeted NIR fluorescent probes (NIR-830-ATF68-IONP and NIR-830-ZHER2:343-IONP, respectively) and were then imaged to further demonstrate the ability of this FMT probe for imaging small animals. View Full-Text
Keywords: fluorescence molecular tomography (FMT); intraoperative optical imaging; targeted optical nanoparticle imaging probes fluorescence molecular tomography (FMT); intraoperative optical imaging; targeted optical nanoparticle imaging probes
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Yang, H.; He, B.; Dai, X.; Satpathy, M.; Yang, L.; Jiang, H. FMTPen: A Miniaturized Handheld Fluorescence Molecular Tomography Probe for Image-Guided Cancer Surgery. Photonics 2015, 2, 279-287.

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