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Photonics
Volume 10
Issue 4
10.3390/photonics10040442
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Communication

Detection of Cutaneous Blood Flow Changes Associated with Diabetic Microangiopathies in Type 2 Diabetes Patients Using Incoherent Optical Fluctuation Flowmetry

by
Alexey Glazkov
1,*,
Ksenia Krasulina
1,
Polina Glazkova
1,
Andrey Tarasov
1,2,*,
Denis Lapitan
1,
Yulia Kovaleva
1 and
Dmitry Rogatkin
1
1
Moscow Regional Research and Clinical Institute (“MONIKI”), 129110 Moscow, Russia
2
Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics” of Russian Academy of Sciences, 119333 Moscow, Russia
*
Authors to whom correspondence should be addressed.
Photonics 2023, 10(4), 442; https://doi.org/10.3390/photonics10040442
Submission received: 28 February 2023 / Revised: 6 April 2023 / Accepted: 10 April 2023 / Published: 13 April 2023
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Abstract

The aim of the present study was to evaluate changes in cutaneous blood flow detected by incoherent optical fluctuation flowmetry (IOFF) in diabetic patients with diagnosed microangiopathies. The study includes 52 patients with type 2 diabetes mellitus (12 males, 40 females, median age 57 (51; 60) years). All patients were examined using the IOFF method using functional tests: occlusion test on the index finger, local heat test on the dorsum of the foot, and local heat test on the big toe. The patients were divided into 2 groups: 13 patients with both diabetic retinopathy and diabetic nephropathy (Group 2, severe microcirculatory disorders) and 39 patients with only 1 microangiopathic complication or without any (Group 1). Local thermal hyperaemia (LTH2_1) was higher in Group 1 than in Group 2 (p = 0.011). Post-occlusive reactive hyperaemia (PORH_2) was higher in Group 2 than in Group 1 (p = 0.009). No changes were detected on the big toe. When PORH_2 and LTH2_1 were used in combination, the area under the ROC curve (95% CI) was 0.733 (0.62 to 0.846). Thus, the IOFF method has the potential to accurately detect blood flow abnormalities associated with diabetic microangiopathies.
Keywords: incoherent optical fluctuation flowmetry (IOFF); diabetes mellitus; microangiopathy; microvascular reactivity; local thermal hyperaemia; post-occlusive reactive hyperaemia incoherent optical fluctuation flowmetry (IOFF); diabetes mellitus; microangiopathy; microvascular reactivity; local thermal hyperaemia; post-occlusive reactive hyperaemia

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MDPI and ACS Style

Glazkov, A.; Krasulina, K.; Glazkova, P.; Tarasov, A.; Lapitan, D.; Kovaleva, Y.; Rogatkin, D. Detection of Cutaneous Blood Flow Changes Associated with Diabetic Microangiopathies in Type 2 Diabetes Patients Using Incoherent Optical Fluctuation Flowmetry. Photonics 2023, 10, 442. https://doi.org/10.3390/photonics10040442

AMA Style

Glazkov A, Krasulina K, Glazkova P, Tarasov A, Lapitan D, Kovaleva Y, Rogatkin D. Detection of Cutaneous Blood Flow Changes Associated with Diabetic Microangiopathies in Type 2 Diabetes Patients Using Incoherent Optical Fluctuation Flowmetry. Photonics. 2023; 10(4):442. https://doi.org/10.3390/photonics10040442

Chicago/Turabian Style

Glazkov, Alexey, Ksenia Krasulina, Polina Glazkova, Andrey Tarasov, Denis Lapitan, Yulia Kovaleva, and Dmitry Rogatkin. 2023. "Detection of Cutaneous Blood Flow Changes Associated with Diabetic Microangiopathies in Type 2 Diabetes Patients Using Incoherent Optical Fluctuation Flowmetry" Photonics 10, no. 4: 442. https://doi.org/10.3390/photonics10040442

APA Style

Glazkov, A., Krasulina, K., Glazkova, P., Tarasov, A., Lapitan, D., Kovaleva, Y., & Rogatkin, D. (2023). Detection of Cutaneous Blood Flow Changes Associated with Diabetic Microangiopathies in Type 2 Diabetes Patients Using Incoherent Optical Fluctuation Flowmetry. Photonics, 10(4), 442. https://doi.org/10.3390/photonics10040442

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