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Article

Development of a Green Extraction Process from Residues of Assyrtiko Wine Production for Cosmetic Applications

by
Styliani Kalafateli
1,
Agni-Areti Freri
1,
Georgios Stavropoulos
2,
Andromachi Tzani
1 and
Anastasia Detsi
1,*
1
Laboratory of Organic Chemistry, School of Chemical Engineering, National Technical University of Athens, Zografou Campus, 15772 Athens, Greece
2
KORRES SA-NATURAL PRODUCTS, 57th Km Athens-Lamia Road, 32011 Oinofita Viotia, Greece
*
Author to whom correspondence should be addressed.
Separations 2025, 12(10), 265; https://doi.org/10.3390/separations12100265
Submission received: 29 July 2025 / Revised: 12 September 2025 / Accepted: 25 September 2025 / Published: 30 September 2025
(This article belongs to the Special Issue Novel Solvents and Methods for Extraction of Chemicals)

Abstract

Vitis vinifera L. cultivar, “Assyrtiko”, is a famous grape variety native to Santorini island. Its wine production residues are rich in bioactive polyphenols, making them valuable for extraction and use in cosmetics. The aim of this work was the development and optimization of an extraction process from “Assyrtiko” Wine Production Residue (AWPR), using a Natural Deep Eutectic Solvent (NaDES) as the extraction medium. Four NaDESs were synthesized and screened for the extraction, and the extracts were evaluated for Total Phenolic Content (TPC) and Total Flavonoid Content (TFC). The NaDES comprising betaine and 1,3-propanediol was chosen for further analysis because of its effectiveness as an extraction solvent. The extraction process was optimized using a Box–Behnken experimental design. The NaDES %w/w content in the NaDES/water system was found to play the most statistically significant role in the quality of the extracts, assessed via TPC and TFC values. The quality of the extract obtained from the optimal conditions was practically stable with respect to TPC and TFC after long storage, suggesting that NaDESs have a potential “protective” effect for the extracted phytochemicals and give energy-efficient character to the process. This extract was also directly incorporated into a moisturizing cosmetic formulation, which remained homogeneous and stable after testing, demonstrating the extract’s potential for cosmetic applications.
Keywords: “Assyrtiko” wine production residue; Natural Deep Eutectic Solvents; extraction; Box–Behnken experimental design; cosmetic cream “Assyrtiko” wine production residue; Natural Deep Eutectic Solvents; extraction; Box–Behnken experimental design; cosmetic cream

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MDPI and ACS Style

Kalafateli, S.; Freri, A.-A.; Stavropoulos, G.; Tzani, A.; Detsi, A. Development of a Green Extraction Process from Residues of Assyrtiko Wine Production for Cosmetic Applications. Separations 2025, 12, 265. https://doi.org/10.3390/separations12100265

AMA Style

Kalafateli S, Freri A-A, Stavropoulos G, Tzani A, Detsi A. Development of a Green Extraction Process from Residues of Assyrtiko Wine Production for Cosmetic Applications. Separations. 2025; 12(10):265. https://doi.org/10.3390/separations12100265

Chicago/Turabian Style

Kalafateli, Styliani, Agni-Areti Freri, Georgios Stavropoulos, Andromachi Tzani, and Anastasia Detsi. 2025. "Development of a Green Extraction Process from Residues of Assyrtiko Wine Production for Cosmetic Applications" Separations 12, no. 10: 265. https://doi.org/10.3390/separations12100265

APA Style

Kalafateli, S., Freri, A.-A., Stavropoulos, G., Tzani, A., & Detsi, A. (2025). Development of a Green Extraction Process from Residues of Assyrtiko Wine Production for Cosmetic Applications. Separations, 12(10), 265. https://doi.org/10.3390/separations12100265

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