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GERMS
Volume 12
Issue 3
10.18683/germs.2022.1339
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Article

Antimicrobial Resistance Trends—A Single-Center Retrospective Study of Healthcare-Associated Pathogens—Postmortem Sampling From Medico-Legal Autopsies in Bucharest

by
Iuliana Diac
1,*,
Cătălin Dogăroiu
1,2,
Arthur-Atilla Keresztesi
3 and
Mihaela Horumbă
4
1
Mina Minovici National Institute of Legal Medicine, 042122 Bucharest, Romania
2
Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
3
Covasna County Institution of Forensic Medicine, 520045 Covasna, Romania
4
Internal Medicine and Cardiology, Colțea Clinical Hospital, 030167 Bucharest, Romania
*
Author to whom correspondence should be addressed.
GERMS 2022, 12(3), 352-360; https://doi.org/10.18683/germs.2022.1339
Submission received: 10 May 2022 / Revised: 16 August 2022 / Accepted: 19 August 2022 / Published: 30 September 2022
Versions Notes

Abstract

Introduction: Healthcare-associated infections are a major concern for healthcare systems around the world. Microorganisms developing resistance to potent antibiotics are an urgent threat to public health. Methods: The present study is a retrospective, single-center study performed at the Mina Minovici National Institute of Legal Medicine, Bucharest, Romania, over a period of ten years (2011–2020). Autopsies for deaths occurring in the hospital setting for which postmortem bacteriological examination was solicited were screened and the recovered data consisted of demographics, hospital stay duration, autopsy data, and postmortem microbiology. Results: In the 516 autopsies recovered we found that carbapenemase-producing Enterobacteriaceae (CPE) isolates from postmortem bacteriology results increased in 2019. Positive postmortem microbiology results were associated with histological infection in over 80% of cases. Positive results for healthcare-related pathogens were associated with prolonged hospital stay. In our data vancomycin-resistant enterococci were isolated from 2015. Conclusions: Postmortem bacteriology results from medico-legal autopsies mirror antimicrobial resistance trends from hospital settings with several limitations due to the scarcity of solicitations.
Keywords: postmortem microbiology; antimicrobial resistance; ESKAPE; healthcare associated infections postmortem microbiology; antimicrobial resistance; ESKAPE; healthcare associated infections

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MDPI and ACS Style

Diac, I.; Dogăroiu, C.; Keresztesi, A.-A.; Horumbă, M. Antimicrobial Resistance Trends—A Single-Center Retrospective Study of Healthcare-Associated Pathogens—Postmortem Sampling From Medico-Legal Autopsies in Bucharest. GERMS 2022, 12, 352-360. https://doi.org/10.18683/germs.2022.1339

AMA Style

Diac I, Dogăroiu C, Keresztesi A-A, Horumbă M. Antimicrobial Resistance Trends—A Single-Center Retrospective Study of Healthcare-Associated Pathogens—Postmortem Sampling From Medico-Legal Autopsies in Bucharest. GERMS. 2022; 12(3):352-360. https://doi.org/10.18683/germs.2022.1339

Chicago/Turabian Style

Diac, Iuliana, Cătălin Dogăroiu, Arthur-Atilla Keresztesi, and Mihaela Horumbă. 2022. "Antimicrobial Resistance Trends—A Single-Center Retrospective Study of Healthcare-Associated Pathogens—Postmortem Sampling From Medico-Legal Autopsies in Bucharest" GERMS 12, no. 3: 352-360. https://doi.org/10.18683/germs.2022.1339

APA Style

Diac, I., Dogăroiu, C., Keresztesi, A.-A., & Horumbă, M. (2022). Antimicrobial Resistance Trends—A Single-Center Retrospective Study of Healthcare-Associated Pathogens—Postmortem Sampling From Medico-Legal Autopsies in Bucharest. GERMS, 12(3), 352-360. https://doi.org/10.18683/germs.2022.1339

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