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Article

A Combination Extract of Gardeniae Fructus and Perillae Folium Exerts Anti-Inflammatory Effects on LPS-Activated RAW 264.7 Mouse Macrophages via an ER Stress-Induced CHOP Pathway

Department of Pathology, College of Korean Medicine, Gachon University, Seongnam 13120, Korea
Academic Editor: Adriana Trifan
Processes 2021, 9(9), 1632; https://doi.org/10.3390/pr9091632
Received: 10 July 2021 / Revised: 3 September 2021 / Accepted: 7 September 2021 / Published: 10 September 2021
(This article belongs to the Special Issue Pharmacodynamics Modeling of Anti-inflammatory Drugs)
The aim of this study is to investigate the effects of a combination extract of Gardeniae Fructus and Perillae Folium (GP) on inflammatory reactions in lipopolysaccharide (LPS)-activated mouse macrophages RAW 264.7 cells. Multiplex cytokine assay, Fluo-4 calcium assay, Flow cytometry assay for phospho-P38 MAPK, and quantitative PCR were carried out. GP significantly reduced LPS-induced productions of macrophage inflammatory protein (MIP)-1α and monokine induced by gamma interferon (MIG) and release of intracellular calcium in LPS-activated RAW 264.7 cells. GP also significantly inhibited P38 MAPK phosphorylation and mRNA levels of Chop, Camk2a, Stat1, Stat3, Jak2, Fas, Nos2, and Ptgs2 in LPS-activated RAW 264.7 cells. Taken together, this study represents that GP exerts anti-inflammatory effects on LPS-activated RAW 264.7 cells via ER stress-induced CHOP pathway. View Full-Text
Keywords: Gardeniae Fructus; Perillae Folium; anti-inflammation; macrophage; cytokine; CHOP; calcium; P38 MAPK Gardeniae Fructus; Perillae Folium; anti-inflammation; macrophage; cytokine; CHOP; calcium; P38 MAPK
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MDPI and ACS Style

Park, W. A Combination Extract of Gardeniae Fructus and Perillae Folium Exerts Anti-Inflammatory Effects on LPS-Activated RAW 264.7 Mouse Macrophages via an ER Stress-Induced CHOP Pathway. Processes 2021, 9, 1632. https://doi.org/10.3390/pr9091632

AMA Style

Park W. A Combination Extract of Gardeniae Fructus and Perillae Folium Exerts Anti-Inflammatory Effects on LPS-Activated RAW 264.7 Mouse Macrophages via an ER Stress-Induced CHOP Pathway. Processes. 2021; 9(9):1632. https://doi.org/10.3390/pr9091632

Chicago/Turabian Style

Park, Wansu. 2021. "A Combination Extract of Gardeniae Fructus and Perillae Folium Exerts Anti-Inflammatory Effects on LPS-Activated RAW 264.7 Mouse Macrophages via an ER Stress-Induced CHOP Pathway" Processes 9, no. 9: 1632. https://doi.org/10.3390/pr9091632

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