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Ameliorative Effect of Heat-Killed Lactobacillus plantarum L.137 and/or Aloe vera against Colitis in Mice

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Department of Biology, Faculty of Science, Kafrelsheikh University, Kafrelsheikh 33511, Egypt
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Department of Pathology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh 33511, Egypt
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Department of Infectious Diseases, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh 33511, Egypt
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Department of Biology, College of Science, Jouf University, Sakaka 2014, Saudi Arabia
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Department of Zoology, Faculty of Science, Fayoum University, Fayoum 63514, Egypt
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Department of Entomology, Faculty of Science, Kafrelsheikh University, Kafrelsheikh 33511, Egypt
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Department of Biology, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 84428, Saudi Arabia
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Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Bani-Suef 62514, Egypt
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Authors to whom correspondence should be addressed.
Processes 2020, 8(2), 225; https://doi.org/10.3390/pr8020225 (registering DOI)
Received: 27 January 2020 / Revised: 10 February 2020 / Accepted: 11 February 2020 / Published: 15 February 2020
(This article belongs to the Section Biological Systems)
Inflammatory bowel disease (IBD) is one of the predominant intestinal diseases associated with chronic inflammation and ulceration of the colon. This study explored the ameliorative effect of Aloe vera extract (Aloe) and/or heat-killed Lactobacillus plantarum L.137 (HK L.137) on dextran sodium sulfate (DSS)-induced colitis in mice. Aloe and/or HK L.137 were supplied for 9 days and the mice were challenged with DSS for 7 days. The DSS group demonstrated bloody diarrhea, colitis of high histologic grade, increased nuclear factor-kappa B (NF-κB) p65, inducible nitric oxide synthase (iNOS), myeloperoxidase (MPO), interleukin (IL)-6, and tumor necrosis factor (TNF)-α, and decreased IL-10 expression. These alterations were dwindled in DSS-induced mice treated with Aloe and HK L.137 separately. Aloe and HK L.137 together have augmented the therapeutic effect of each other. In conclusion, our findings demonstrated that Aloe and/or HK L.137 ameliorated DSS-induced colitis by promoting the secretion of anti-inflammatory cytokines and suppressing pro-inflammatory mediators. This study indicated that A. vera may function synergistically with HK L.137 to confer an effective strategy to prevent colitis. View Full-Text
Keywords: ulcerative colitis; Aloe; HK L.137; DSS; cytokines ulcerative colitis; Aloe; HK L.137; DSS; cytokines
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MDPI and ACS Style

Ismaeil, H.; Abdo, W.; Amer, S.; Tahoun, A.; Massoud, D.; Zanaty, E.; Bin-Jumah, M.; Mahmoud, A.M. Ameliorative Effect of Heat-Killed Lactobacillus plantarum L.137 and/or Aloe vera against Colitis in Mice. Processes 2020, 8, 225.

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